Sestrin 3 Proteins (SESN3)

SESN3 encodes a member of the sestrin family of stress-induced proteins. Additionally we are shipping Sestrin 3 Antibodies (71) and Sestrin 3 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SESN3 143686 P58005
SESN3 315427  
SESN3 75747 Q9CYP7
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Top Sestrin 3 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details
Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
Details

SESN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)
Mouse (Murine) ,

More Proteins for Sestrin 3 (SESN3) Interaction Partners

Human Sestrin 3 (SESN3) interaction partners

  1. in FOXO3 (show FOXO3 Proteins)-death-resistant cells no point mutations in the TP53 (show TP53 Proteins)-DBD were found-in these cells FOXO3 (show FOXO3 Proteins)-TP53 (show TP53 Proteins) complexes are formed and FOXO3 (show FOXO3 Proteins)-binding to the BIM (show BCL2L11 Proteins)-promoter, but not the induction of the detoxifying protein SESN3, were prevented, which in turn increased chemo-protection in this type of high-stage-derived neuroblastoma (show ARHGEF16 Proteins) (NB)cells

  2. Treatment with cucurbitacin B to sestrin-3 siRNA treated EGFR (show EGFR Proteins)-mutant cells further amplified the decrease in cell-viability and caused more sustained G2-phase cell cycle arrest, suggesting that these effects are mediated partly through sestrin-3.

  3. study revealed high confidence set of BMos (integrated with DNase I (show DNASE1 Proteins) hypersensitivity sites) in the upstream regulatory regions of SESN3 that could be bound by transcription factors from multiple families including FOXOs, SMADs, SOXs, TCFs and HNF4A (show HNF4A Proteins). TF-TF network analysis established hubs of interaction that include SMAD3 (show SMAD3 Proteins), TCF3 (show TCF3 Proteins), SMAD2 (show SMAD2 Proteins), HDAC2 (show HDAC2 Proteins), SOX2 (show SOX2 Proteins), TAL1 (show TAL1 Proteins) and TCF12 (show TCF12 Proteins) as well as the likely protein complexes formed between them

  4. SESN3 positively regulates the gene network module in macrophages, microglia and neurons.

  5. Suggest that inhibitory effect of ethanol on Sesn3 may play an important role in the development of ethanol-induced fatty liver.

  6. findings suggest the existence of a novel mechanism for the generation of antileukemic responses in CML (show BCR Proteins) cells, involving upregulation of SESN3 expression.

  7. Sestrin 3 is upregulated in T2D and could influence skeletal muscle differentiation without altering glucose and lipid metabolism.

  8. HSF1 (show HSF1 Proteins)/SESN3/reactive oxygen species/p21(Cip1/WAF1 (show CDKN1A Proteins))-mediated deceleration of cell growth may contribute to cell defense systems protecting the organism from excessive proliferation of cells that overexpress activated Ras oncoproteins.

  9. FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

Mouse (Murine) Sestrin 3 (SESN3) interaction partners

  1. Sesn3 liver-specific knockout mice exhibit insulin (show INS Proteins) resistance and glucose intolerance. Sesn3 interacts with and activates mTORC2 (show CRTC2 Proteins) and subsequently stimulates Akt (show AKT1 Proteins) phosphorylation at Ser473.

  2. Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (show PRKAA1 Proteins) or TSC2. Surprisingly, when coexpressed with a GTP (show AK3 Proteins)-bound constitutively active form of RagB (show RRAGB Proteins) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.

  3. Suggest that inhibitory effect of ethanol on Sesn3 may play an important role in the development of ethanol-induced fatty liver.

  4. Concomitant ablation of Sesn2 (show SESN2 Proteins) and Sesn3 provokes hepatic mTORC1-S6K (show RPS6KB1 Proteins) activation and insulin (show INS Proteins) resistance even in the absence of nutritional overload and obesity.

  5. FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

Sestrin 3 (SESN3) Protein Profile

Protein Summary

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Sestrin 3 Proteins (SESN3)

  • sestrin 3 (SESN3)
  • sestrin 3 (sesn3)
  • sestrin 3 L homeolog (sesn3.L)
  • sestrin 3 (Sesn3)
  • 5630400E15Rik protein
  • BC003348 protein
  • cb261 protein
  • sb:cb261 protein
  • SEST3 protein
  • sestrin-3 protein
  • wu:fb77c04 protein
  • wu:fc41d03 protein
  • wu:fd59d12 protein
  • zgc:56722 protein

Protein level used designations for Sestrin 3 Proteins (SESN3)

sestrin-3 , sestrin 3 , sestrin-3-like

GENE ID SPECIES
428089 Gallus gallus
485118 Canis lupus familiaris
515914 Bos taurus
100526065 Sus scrofa
406840 Danio rerio
443904 Xenopus laevis
451495 Pan troglodytes
699329 Macaca mulatta
100038137 Xenopus (Silurana) tropicalis
100354919 Oryctolagus cuniculus
100406991 Callithrix jacchus
100475423 Ailuropoda melanoleuca
100557159 Anolis carolinensis
100599268 Nomascus leucogenys
143686 Homo sapiens
315427 Rattus norvegicus
75747 Mus musculus
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