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Prion-like protein that has PrP(C)-like neuroprotective activity.
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Data suggest that expression of shadoo in neuron or hepatocyte cell lines induces same toxic phenotype of drug hypersensitivity as prion protein/PrP (show PRNP ELISA Kits)(-central region); this effect is counteracted by co-expression of PrP-wild-type.
No significant differences in survival, the incubation period of prion (show PRNP ELISA Kits) disease or other disease features were observed between Sho mutant and WT mice
These observations suggest that Shadoo can affect the prion (show PRNP ELISA Kits) replication process by (i) acting as a holdase and (ii) interfering with the dominant-negative inhibitor effect of the C1 fragment.
Data suggest that glycosylation status of the prion protein (show PRNP ELISA Kits) and yet-to-be-dentified proteases modulate internal C1 and C2 endoproteolysis of Shadoo (shadow of prion protein) and Doppel (doppelganger (show PRND ELISA Kits) prion (show PRNP ELISA Kits)) in mouse neurons.
binding of Sho to anionic liposomes has disruptive effect on integrity of lipid bilayer leading to formation of supramolecular lipid-protein complexes. prion (show PRNP ELISA Kits) diseases might depend on the oligomerization state of Sho and on these lipoprotein assembles.
Sho is not pi, or, given the accumulating data for many activities for PrP (C (show PRNP ELISA Kits)) , the pi hypothesis invoking a discrete signaling pathway to maintain neuronal viability is no longer tenable.
Here we report that Shadoo (Sho)-a member of the prion protein (show PRNP ELISA Kits) superfamily-is also found in the nucleus of several neural and non-neural cell lines as visualized by using an YFP-Sho construct
the Sho region N-terminal to the hydrophobic domain includes tandem positively charged "RGG boxes", predicted to bind RNA. Here, we demonstrate that Sho binds DNA and RNA in vitro via this arginine-rich region.
using various Prnp (show PRNP ELISA Kits) transgenic mouse lines and lentiviral vectors expressing shRNAs that target the Shadoo-encoding mRNA, we further demonstrate the specific requirement of at least one of these two PrP-related proteins at early developmental stages
Knockout of the prion protein (PrP (show PRNP ELISA Kits))-like Sprn gene does not produce embryonic lethality in combination with PrP(C (show PRNP ELISA Kits))-deficiency.
Shadoo is degraded in Scrapie-infected rodents and cultured cells mediated by proteasome degradation after modification by ubiquitination.
a conserved physiological activity between PrP(C (show PRNP ELISA Kits)) and Sho to protect cells from stress-induced toxicity and suggests that Sho and PrP(C (show PRNP ELISA Kits)) might act on similar signaling pathways.
A novel solid phase technology for high- throughput synthesis of the SPRN gene is reported.
Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease
Genetic characterization of PRNP (show PRNP ELISA Kits) promoter indel variations and the polymorphism of open reading frames (ORFs) of PRNP (show PRNP ELISA Kits) and bovine prion (show PRNP ELISA Kits)-like Shadoo (SPRN) genes, are reported.
Sho as a non-PrP (show PRNP ELISA Kits) specific marker for prion (show PRNP ELISA Kits) infections, with obex as the best tissue source for the detection of Sho in transmissible spongiform encephalopathies rapid tests.
SPRN has the typical two-exon PRNP (show PRNP ELISA Kits) arrangement, with the CDS (show ABHD5 ELISA Kits) fully contained within exon 2; furthermore, it codes for a 143-amino-acid protein with 74.8% identity and 84.7% similarity with the human PRNP (show PRNP ELISA Kits).
Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).
, protein shadoo
, shadow of prion protein 1
, hypothetical protein BC004409
, shadow of prion protein
, shadoo protein Sho