Sialic Acid Binding Ig-Like Lectin 11 Proteins (SIGLEC11)

Human Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11) interaction partners

1. The authors demonstrated that the human-specific pathogen Escherichia coli K1 uses its polysialic acid capsule as a molecular mimic to engage Siglec-11 and escape killing. In contrast, engagement of the activating counterpart Siglec-16 increases elimination of bacteria.

2. The results indicate potential roles for Siglec-11 in ovarian physiology and human evolution.

3. Siglec-11 ectopically expressed on murine microglia interacts with PSA (show PLAG1 Proteins) on neurons, reduces LPS (show IRF6 Proteins)-induced gene transcription of proinflammatory mediators, impairs phagocytosis and alleviates microglial neurotoxicity.

4. cloning and characterization; a recently evolved signaling that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages including brain microglia

5. expressed in human but not in chimpanzee brain microglia; findings indicate that human SIGLEC11 emerged through human-specific gene conversion by an adjacent pseudogene

6. SIGLEC16 encodes a DAP12 (show TYROBP Proteins)-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.