Sialic Acid Binding Ig-Like Lectin 11 Proteins (SIGLEC11)

SIGLEC11 encodes a member of the sialic acid-binding immunoglobulin-like lectin family. Additionally we are shipping SIGLEC11 Antibodies (54) and SIGLEC11 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGLEC11 114132 Q96RL6
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Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days

SIGLEC11 Proteins by Origin and Source

Origin Expressed in Conjugate

More Proteins for Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11) Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11) interaction partners

  1. The authors demonstrated that the human-specific pathogen Escherichia coli K1 uses its polysialic acid capsule as a molecular mimic to engage Siglec-11 and escape killing. In contrast, engagement of the activating counterpart Siglec-16 increases elimination of bacteria.

  2. The results indicate potential roles for Siglec-11 in ovarian physiology and human evolution.

  3. Siglec-11 ectopically expressed on murine microglia interacts with PSA on neurons, reduces LPS-induced gene transcription of proinflammatory mediators, impairs phagocytosis and alleviates microglial neurotoxicity.

  4. cloning and characterization; a recently evolved signaling that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages including brain microglia

  5. expressed in human but not in chimpanzee brain microglia; findings indicate that human SIGLEC11 emerged through human-specific gene conversion by an adjacent pseudogene

  6. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.

SIGLEC11 Protein Profile

Protein Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SIGLEC11

  • sialic acid binding Ig like lectin 11 (SIGLEC11)

Protein level used designations for SIGLEC11

sialic acid-binding Ig-like lectin 11 , siglec-11 , sialic acid binding Ig-like lectin 11 , sialic acid-binding Ig-like lectin 11-like

114132 Homo sapiens
747721 Pan troglodytes
100387822 Callithrix jacchus
100447534 Pongo abelii
100605002 Nomascus leucogenys
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