anti-Sialidase 1 (Lysosomal Sialidase) (NEU1) Antibodies

The protein encoded by NEU1 is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Additionally we are shipping NEU1 Proteins (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NEU1 4758 Q99519
NEU1 18010 O35657
NEU1 24591  
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Top anti-NEU1 Antibodies at

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-NEU1 Antibody Titration:  5.0ug/ml  Positive Control:  Fetal Pancreas cell lysate 100 μL 2 to 3 Days
Human Mouse Un-conjugated WB 100 μL 11 to 14 Days
Cow Rabbit Un-conjugated IHC, IHC (p), WB Anti-NEU1 / NEU antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this prod ... 100 μL 11 to 14 Days
Human Mouse Un-conjugated ELISA, WB NEU1 monoclonal antibody (M01), clone 3F9. Western Blot analysis of NEU1 expression in PC-12. NEU1 monoclonal antibody (M01), clone 3F9. Western Blot analysis of NEU1 expression in IMR-32. 100 μg 11 to 12 Days
Human Rabbit Un-conjugated WB Western blot analysis in HepG2 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
Human Rabbit Un-conjugated WB Western blot analysis of Neu1 expression in mouse liver (A), rat liver (B) whole cell lysates. 200 μL 13 to 14 Days
Human Rabbit Un-conjugated WB NEU1 Antibody (Center) (ABIN1881576) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the NEU1 antibody detected the NEU1 protein (arrow). 400 μL 10 to 11 Days
Mouse Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various tissues, using NEU1 antibody (ABIN5973721) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat brain using NEU1 antibody (ABIN5973721) at dilution of 1/100 (40x lens). 100 μL 11 to 16 Days
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μL 2 to 3 Days

Top referenced anti-NEU1 Antibodies

  1. Human Polyclonal NEU1 Primary Antibody for WB - ABIN1881576 : Caciotti, Di Rocco, Filocamo, Grossi, Traverso, dAzzo, Cavicchi, Messeri, Guerrini, Zammarchi, Donati, Morrone: Type II sialidosis: review of the clinical spectrum and identification of a new splicing defect with chitotriosidase assessment in two patients. in Journal of neurology 2009 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal NEU1 Primary Antibody for WB - ABIN2732027 : Luzina, Lockatell, Hyun, Kopach, Kang, Noor, Liu, Lillehoj, Lee, Miranda-Ribera, Todd, Goldblum, Atamas: Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis. in American journal of physiology. Lung cellular and molecular physiology 2017 (PubMed)

  3. Human Monoclonal NEU1 Primary Antibody for IHC, WB - ABIN2732032 : Hyun, Liu, Liu, Cross, Verceles, Magesh, Kommagalla, Kona, Ando, Luzina, Atamas, Piepenbrink, Sundberg, Guang, Ishida, Lillehoj, Goldblum: The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo. in Glycobiology 2016 (PubMed)

More Antibodies against NEU1 Interaction Partners

Human Sialidase 1 (Lysosomal Sialidase) (NEU1) interaction partners

  1. Quantifying all four G. vaginalis clades discriminates between Bacterial vaginosis (BV) microbiota and normal microbiota more accurately than measuring G. vaginalis sialidase A gene. Clade 4 is strongly associated with BV microbiota, despite most clade 4 strains lacking the sialidase A gene

  2. A subsequent mechanistic study revealed that TRPV1 induced Ca(2+) influx to regulate p53 activation via calcineurin-ATF3 transcriptional cascade. Finally, the effect of TRPV1 on melanoma growth was proved in vivo. Altogether, our study demonstrates that TRPV1 is a potential tumor suppressor in melanoma.

  3. Toll-Like Receptors 2 and 4 Predict New-Onset Atrial Fibrillation in Acute Myocardial Infarction Patients.

  4. Binding of elastin-derived peptides (EDP) to the elastin receptor complex (ERC) indirectly modulates CD36 sialylation level and regulates oxidized LDL uptake through NEU1 sialidase.

  5. Association of TRPV1 and TLR4 through the interleukin-1 receptor domain potentiates TRPV1 activity by blocking activation-induced desensitization

  6. in monocytes/macrophages, NEU1 is interconnected in a positive feedback loop with lipopolysaccharides and IL-1beta as enhancers of inflammation, and may therefore promote atherosclerosis and plaque instability

  7. Patients with minimally invasive and lepidic adenocarcinomas were categorized as low-risk group with high EGFR mutation rate; Patients with micro-papillary and solid adenocarcinomas were categorized as high-risk with lower EGFR mutation rate

  8. Transmembrane topology and dimerization ability of NEU1 have been reported.

  9. this work identified NEU1 as a novel biomarker for both diagnosis and prognosis in hepatocellular carcinoma

  10. Our combined data indicate that as HPMECs achieve confluence and CD31 ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn, which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 to CD31, permitting NEU1-mediated desialylation of CD31.

  11. neuraminidase-1 (Neu1) in complex with matrix metalloproteinase-9 and G protein-coupled receptor tethered to RTKs and TLRs is identified as a major target in multistage tumorigenesis [review]

  12. EGFR protein, human is predictive of adjuvant chemo response. Also, It is a prognostic factor.

  13. Data suggest that mutations c.90delC (p.Tyr30Ter) and c.572A>T (p.Asp191Val) of the NFU1 gene probably underlie the pathogenesis of multiple mitochondrial dysfunction syndrome (MMDS).

  14. Elevated NEU1 expression alters functional activities of distinct lung cell types in vitro and recapitulates lymphocytic infiltration and collagen accumulation in vivo, consistent with mechanisms implicated in lung fibrosis.

  15. initial treatment with an EGFR-TKI is a reasonable option for patients presenting with EGFR mutation-positive NSCLC and a CM.

  16. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer.

  17. NEU1 siRNA can effectively inhibit proliferation, apoptosis, and invasion of human ovarian cancer cells by targeting lysosome and oxidative phosphorylation signaling, which can serve as a new target ovarian cancer treatment

  18. How the point mutations of the neuraminidase sequences affected the susceptibility of H9N2 virus to oseltamivir is still to be determined and deserve further investigations

  19. Our study shows that the 340-cavity is not an occasional or atypical domain in NA subtypes, and it has potential to function as a new hotspot for influenza drug binding.

  20. Basal Neu-1 catalytic activity is strongly increased in aged cells.

Cow (Bovine) Sialidase 1 (Lysosomal Sialidase) (NEU1) interaction partners

  1. NEU1 gene is not responsible for the lysosomal storage disease of Japanese Black cattle.

Mouse (Murine) Sialidase 1 (Lysosomal Sialidase) (NEU1) interaction partners

  1. de-toxification of lipopolysaccharide by circulating alkaline phosphatase (AP) isozymes was incapacitated during sepsis caused by Salmonella or E. coli through activation of host Toll-like receptor 4, which triggered Neu1 and Neu3 neuraminidase induction.

  2. Pseudomonas aeruginosa flagellin provokes NEU1-mediated airway shedding of MUC1-ectodomain, which functions as a decoy receptor protecting against lethal Pa lung infection.

  3. NEU1/3 activity mediates IL-6 production in lupus-prone mesangial cells possibly through an IgG-receptor complex signaling pathway.

  4. the reduction in NEU1 expression or function decreases atherosclerosis in mice via its significant effects on lipid metabolism and inflammatory processes

  5. The NEU1 exists on the cell surface of mouse thymocytes and CD5 is a natural substrate for it.

  6. Neu1 inhibits lipolysis induced by beta-adrenergic stimulation in adipocytes via interactions with Plin1 on lipid drops.

  7. Neu1 is the only lysosomal multienzyme complex gene underexpressed in mucopolysaccharidosis type I mice.

  8. Neu1 desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.

  9. Data indicate a role for neuraminidase 1 (Neu1) in regulating Siglec E protein-toll-like receptor 4 (TLR4) interaction and endotoxemia.

  10. elastin-derived peptides as an enhancer of atherogenesis and defines the Neuraminidase 1/PI3Kgamma signalling pathway as a key mediator

  11. significant increases in Col1a1, serine/threonine-protein kinase 1, Ctnnb1, CSRNP1, Ddit4, Cyp2e1, and Krit1 expressions and great decreases inreceptor D2, Neu1, and Dhcr7 expressions following long-term exposure to TiO2 NPs

  12. NEU1 deficiency has a role in determining amyloid precursor protein levels and amyloid-beta secretion via deregulated lysosomal exocytosis

  13. Neu1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and -9 activation, cellular signaling and pro-inflammatory responses.

  14. The activity of NEU1 was preferentially higher in epididymal fat and lower in the livers of two strains of obese and diabetic mice.

  15. these studies identify Neu1 as a novel component of the signaling pathways of energy metabolism and glucose uptake.

  16. The rescue of sialidase activity in hypomorphic sialidase mice using helper-dependent adenovirus resulted in increased VLDL production and an increase in MTP levels.

  17. Data indicate that sialidases Neu1 and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.

  18. Neuraminidase 1 as a modulator of cell receptors. (Review)

  19. a novel Neu1 and MMP9 cross-talk in alliance with TLR4 on the cell surface that is essential for ligand activation of TLRs and subsequent cellular signaling.

  20. The deficiency of lysosomal neuraminidase may result in a serious hearing loss and morphological alterations of ear.

NEU1 Antigen Profile

Protein Summary

The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.

Gene names and symbols associated with NEU1

  • neuraminidase 1 (NEU1) antibody
  • neuraminidase 1 (lysosomal sialidase) L homeolog (neu1.L) antibody
  • neuraminidase 1 (neu1) antibody
  • neuraminidase 1 (Neu1) antibody
  • AA407268 antibody
  • AA407316 antibody
  • Aglp antibody
  • Apl antibody
  • Bat-7 antibody
  • Bat7 antibody
  • G9 antibody
  • Map-2 antibody
  • MGC81958 antibody
  • NANH antibody
  • Neu antibody
  • Neu-1 antibody
  • SIAL1 antibody

Protein level used designations for NEU1

G9 sialidase , N-acetyl-alpha-neuraminidase 1 , acetylneuraminyl hydrolase , exo-alpha-sialidase , lysosomal sialidase , sialidase-1 , sialidase 1 (lysosomal sialidase) , neuraminidase , isotocin , Isotocin-neurophysin IT 1 , neuraminidase 1 , sialidase-1-like , HLA-B-associated transcript 7 , sialidase 1

4758 Homo sapiens
444511 Xenopus laevis
471968 Pan troglodytes
481717 Canis lupus familiaris
505554 Bos taurus
716740 Macaca mulatta
100124381 Sus scrofa
100136555 Salmo salar
100342130 Oryctolagus cuniculus
100408501 Callithrix jacchus
100595428 Nomascus leucogenys
18010 Mus musculus
24591 Rattus norvegicus
100728899 Cavia porcellus
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