anti-Sirtuin 5 (SIRT5) Antibodies

SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 5 Kits (20) and Sirtuin 5 Proteins (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT5 23408 Q9NXA8
SIRT5 68346 Q8K2C6
SIRT5 306840 Q68FX9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Sirtuin 5 Antibodies at antibodies-online.com

Showing 10 out of 193 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIRT5 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Human Spermatophore 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SIRT5 Antibody Titration:  5.0ug/ml  ELISA Titer:  1:62500  Positive Control:  Human heart Lanes:   Lane1: Untransfected HEK293T lysate Lane2: mSIRT5-FLAG transfected HEK293T lysate  Primary Antibody Dilution:   1:200  Secondary Antibody:   ProteinA-HRP  Secondary Antibody Dilution:   1:5000  Gene Name:   SIRT5  Submitted by:   Anonymous  There is BioGPS gene expression data showing that SIRT5 is expressed in HEK293T 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$245.00
Details
Human Mouse Un-conjugated FACS, WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 7 to 9 Days
$522.50
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB Human Small Intestine, Muscularis Mucosa: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Vessels: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of anti-SIRT5 Pab (ABIN390180) in Jurkat cell line lysate (35 µg/lane). SIRT5(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$335.50
Details

Top referenced anti-Sirtuin 5 Antibodies

  1. Human Polyclonal SIRT5 Primary Antibody for IHC (fro), IF (p) - ABIN1387080 : Takumida, Takumida, Anniko: Localization of sirtuins in the mouse inner ear. in Acta oto-laryngologica 2014 (PubMed)

  2. Human Polyclonal SIRT5 Primary Antibody for IHC (p), WB - ABIN390180 : Wang, Yi, Li, Cai, He, Ni, Zhou, Cheng, Jin, Fan, Qiu: Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. in BMC cancer 2014 (PubMed)

  3. Human Polyclonal SIRT5 Primary Antibody for WB - ABIN252349 : Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. in Cancer 2011 (PubMed)

  4. Cow (Bovine) Polyclonal SIRT5 Primary Antibody for WB - ABIN2778619 : Mahlknecht, Ho, Letzel, Voelter-Mahlknecht: Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization. in Cytogenetic and genome research 2006 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal SIRT5 Primary Antibody for IHC, IHC (p) - ABIN4353920 : Lv, Liu, Cheng, Yu, Xiong, Hu, Tang, Zeng, Sang: SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer. in Scientific reports 2015 (PubMed)

More Antibodies against Sirtuin 5 Interaction Partners

Human Sirtuin 5 (SIRT5) interaction partners

  1. High SIRT5 expression is associated with Cancer Cell Proliferation.

  2. The DNA variants and SNPs identified in acute Myocardial infection (AMI (show CFD Antibodies)) patients may change SIRT5 level by affecting activity of SIRT5 gene promoter, contributing to the AMI (show CFD Antibodies) development as a risk factor.

  3. In this study, we summarize biological functions of SIRT5 reported in normal tissues and in cancer and discuss potential mechanisms whereby SIRT5 may impact tumorigenesis, particularly focusing on its reported roles in metabolic reprogramming. Finally, we review current efforts to target SIRT5 pharmacologically

  4. The roles of the CDK2 (show CDK2 Antibodies)/SIRT5 axis in gastric cancer.

  5. SIRT5 gene has an important regulatory role in liver carcinogenesis, and may function as a novel potential therapeutic target for HCC (show FAM126A Antibodies).

  6. This study showed that SIRT5 supports the anaplerotic entry of glutamine (show GFPT1 Antibodies) into the TCA cycle in malignant phenotypes of CRC (show CALR Antibodies) via activating GLUD1 (show GLUD1 Antibodies).

  7. Results show that SIRT5 binds to, desuccinylates and inhibits PKM2 activity. Increased levels of reactive oxygen species (ROS) decreases succinylation and activity of PKM2 by increasing its binding to SIRT5. Moreover, inhibition of SIRT5 suppresses tumor cell proliferation through desuccinylation of PKM2 K498.

  8. The function of the three mitochondrial sirtuins (SIRT3 (show SIRT3 Antibodies), SIRT4 (show SIRT4 Antibodies), SIRT5) and their role in disease are reviewed.

  9. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH (show NQO1 Antibodies) homeostasis and redox potential by promoting IDH2 (show IDH2 Antibodies) desuccinylation and G6PD (show G6PD Antibodies) deglutarylation.

  10. Results demonstrated presence of endogenous SIRT5 in mitochondria of cultured SH-EP cells, identified down-regulation of cellular oxidative stress by SIRT5 as one of the possible mechanisms mediating the anti-apoptotic effect of SIRT5 in SH-EP cells.

Mouse (Murine) Sirtuin 5 (SIRT5) interaction partners

  1. Data indicate that sirtuin 5 (SIRT5) is an important mitochondrial enzyme for protection against metabolic and ischemic stress following protein kinase C epsilon (PKCepsilon (show PRKCE Antibodies)) activation in the brain.

  2. findings reveal a key role for SIRT5 in maintaining cardiac oxidative metabolism under pressure overload to ensure survival

  3. Deletion of Sirt5 in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 (show CRMP1 Antibodies) and to mitochondrial fragmentation.

  4. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH (show FDXR Antibodies) homeostasis and redox potential by promoting IDH2 (show IDH2 Antibodies) desuccinylation and G6PD (show G6PD Antibodies) deglutarylation.

  5. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

  6. Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) overexpression significantly increased the expression of sirtuin 3 (SIRT3 (show SIRT3 Antibodies)) and sirtuin 5 (SIRT5).

  7. In the cochlea, the expression of SIRT1 (show SIRT1 Antibodies), 3, and 5 (both mRNA and protein) was decreased in the old mice

  8. These findings establish that regulating heart metabolism and function is a major physiological function of lysine succinylation and SIRT5.

  9. Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH (show SDHA Antibodies)), implicating alteration in SDH (show SDS Antibodies) activity as causative of the injury.

  10. SIRT5 has a role in cellular metabolism with a multiple enzymatic activities

Cow (Bovine) Sirtuin 5 (SIRT5) interaction partners

  1. Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle.

Sirtuin 5 (SIRT5) Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with anti-Sirtuin 5 (SIRT5) Antibodies

  • sirtuin 5 (SIRT5) antibody
  • sirtuin 5 (Sirt5) antibody
  • sirtuin 5 (sirt5) antibody
  • sirtuin 5 L homeolog (sirt5.L) antibody
  • sirtuin 5 (CC1G_00083) antibody
  • 0610012J09Rik antibody
  • 1500032M05Rik antibody
  • AV001953 antibody
  • sir2l5 antibody
  • SIRT5 antibody
  • sirt5-a antibody
  • zgc:92288 antibody

Protein level used designations for anti-Sirtuin 5 (SIRT5) Antibodies

NAD-dependent deacetylase sirtuin-5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial , NAD-dependent protein deacylase sirtuin-5, mitochondrial , SIR2-like protein 5 , regulatory protein SIR2 homolog 5 , silent mating type information regulation 2, S.cerevisiae, homolog 5 , sir2-like 5 , sirtuin type 5 , Regulatory protein SIR2 homolog 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5A, mitochondrial , NAD-dependent protein deacylase sirtuin-5A, mitochondrial , regulatory protein SIR2 homolog 5-a , sirtuin (silent mating type information regulation 2 homolog) 5 , sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin 5 , nad-dependent deacetylase sirtuin-5

GENE ID SPECIES
23408 Homo sapiens
68346 Mus musculus
306840 Rattus norvegicus
420834 Gallus gallus
436878 Danio rerio
478726 Canis lupus familiaris
496346 Xenopus laevis
507347 Bos taurus
700855 Macaca mulatta
747069 Pan troglodytes
6013501 Coprinopsis cinerea okayama7130
100125966 Sus scrofa
100170199 Xenopus (Silurana) tropicalis
100173543 Pongo abelii
100528250 Ictalurus punctatus
100718110 Cavia porcellus
100339154 Oryctolagus cuniculus
100860989 Capra hircus
Selected quality suppliers for anti-Sirtuin 5 (SIRT5) Antibodies
Did you look for something else?