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SIRT7 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 7 Antibodies (172) and Sirtuin 7 Proteins (15) and many more products for this protein.
Showing 5 out of 14 products:
Energy stress strengthens SIRT7-mediated effects on Akt (show AKT1 ELISA Kits) dephosphorylation.
The SIRT7 is mobilized from the nucleolus to the nucleoplasm and promotes DDB1 deacetylation, leading to decreased DDB1-CUL4 association and CRL4 activity.
Data suggest that SIRT7 undergoes Lys (show LYZ ELISA Kits)-63 polyubiquitination, later removed by USP7 (show USP7 ELISA Kits) to repress enzymatic activity of SIRT7; USP7 (show USP7 ELISA Kits) and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (show G6PC ELISA Kits)); SIRT7 targets G6PC (show G6PC ELISA Kits) promoter through ELK4 (show ELK4 ELISA Kits). (SIRT7 = sirtuin 7; USP7 (show USP7 ELISA Kits) = ubiquitin specific peptidase 7 (show USP7 ELISA Kits); G6PC (show G6PC ELISA Kits) = glucose-6-phosphatase catalytic subunit (show G6PC ELISA Kits); ELK4 (show ELK4 ELISA Kits) = transcription factor ELK4 (show ELK4 ELISA Kits))
the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 (show SMAD3 ELISA Kits) levels.
SIRT7 inhibits TR4 degradation by deacetylation of DDB1.
miR (show MLXIP ELISA Kits)-152/SIRT7 axis plays a key role in the regulation of Human dental pulp stem cell senescence.
our study suggests that SIRT7 functions as an oncogene (show RAB1A ELISA Kits) in non-small cell lung cancer (NSCLC), and miR (show MLXIP ELISA Kits)-3666 can target SIRT7 to inhibit NSCLC cell growth by promoting the pro-apoptotic signaling pathway
SIRT7 trans-represses RPS7 (show RPS7 ELISA Kits) gene in the presence of HBx protein.HBx enhances intracellular stability of SIRT7 protein.
Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 ELISA Kits)), endometrial cancer (EC) showed SIRT7 mRNA overexpression, whereas SIRT1 (show SIRT1 ELISA Kits), SIRT2 (show SIRT2 ELISA Kits), SIRT4 (show SIRT4 ELISA Kits) and SIRT5 (show SIRT5 ELISA Kits) were underexpressed, and no significant differences were observed for SIRT3 (show SIRT3 ELISA Kits) and SIRT6 (show SIRT6 ELISA Kits).
This study showed that SIRT7 can be activated by DNA to hydrolyze the acetyl group from lysine residues in vitro on histone peptides and histones in the chromatin context.
Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 (show SIRT4 ELISA Kits) and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 (show TDO2 ELISA Kits) and Nnmt (show NNMT ELISA Kits)); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 (show TDO2 ELISA Kits) and Nnmt (show NNMT ELISA Kits) may serve as markers of HFD consumption. (Tdo2 (show TDO2 ELISA Kits) = tryptophan 2,3-dioxygenase (show TDO2 ELISA Kits); Nnmt (show NNMT ELISA Kits) = nicotinamide N-methyltransferase (show NNMT ELISA Kits))
The Sirt7 mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (show DNMT1 ELISA Kits) and another member of the sirtuin (show SIRT1 ELISA Kits) family, Sirt1 (show SIRT1 ELISA Kits).
These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 (show HIST3H3 ELISA Kits) K18 (show KRT18 ELISA Kits) deacetylation and the maintenance of genome integrity.
miR (show MLXIP ELISA Kits)-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.
The role of SIRT7 has emerged in protein synthesis, chromatin remodelling, cellular survival and lipid metabolism.
SIRT7 stabilizes and activates the GABP alpha (show GABPA ELISA Kits)/GABPbeta complex via deacetylation of GABPbeta1.
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
Study identifies SIRT7 as a cofactor of Myc (show MYC ELISA Kits) for transcriptional repression and delineates a druggable regulatory branch of the ER stress response that prevents and reverts fatty liver disease.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
, sirtuin 7
, novel protein similar to vertebratesirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) (SIRT7)
, NAD-dependent deacetylase sirtuin-7
, NAD-dependent protein deacetylase sirtuin-7
, SIR2-like protein 7
, regulatory protein SIR2 homolog 7
, silent mating type information regulation 2, S.cerevisiae, homolog 7
, sir2-related protein type 7
, sirtuin type 7
, NAD-dependent deacetylase sirtuin 7