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SIRT7 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein.
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miR (show MLXIP ELISA Kits)-3666 is an important regulator of breast cancer development. The overexpression of miR (show MLXIP ELISA Kits)-3666 inhibits breast cancer cell proliferation by inhibiting SIRT7.
Authors evaluated the expression of known targets of miR (show MLXIP ELISA Kits)-125a and found that sirtuin-7, matrix metalloproteinase-11 (show MMP11 ELISA Kits), and c-Raf (show RAF1 ELISA Kits) were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR (show MLXIP ELISA Kits)-125a.
We found a negative correlation between mRNA levels of SIRT1 (show SIRT1 ELISA Kits) in VAT of obese individuals and SIRT7 in VAT of the normal-weight subjects and expression of the relevant miRNAs.
Data indicate the role of SIRT7 in inhibiting SMAD4 (show SMAD4 ELISA Kits)-mediated breast cancer metastasis providing a possible therapeutic avenue.
Energy stress strengthens SIRT7-mediated effects on Akt (show AKT1 ELISA Kits) dephosphorylation.
The SIRT7 is mobilized from the nucleolus to the nucleoplasm and promotes DDB1 deacetylation, leading to decreased DDB1-CUL4 association and CRL4 activity.
Data suggest that SIRT7 undergoes Lys-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7; USP7 and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC); SIRT7 targets G6PC promoter through ELK4. (SIRT7 = sirtuin 7; USP7 = ubiquitin specific peptidase 7; G6PC = glucose-6-phosphatase catalytic subunit; ELK4 = transcription factor ELK4)
the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 (show SMAD3 ELISA Kits) levels.
SIRT7 inhibits TR4 degradation by deacetylation of DDB1.
miR (show MLXIP ELISA Kits)-152/SIRT7 axis plays a key role in the regulation of Human dental pulp stem cell senescence.
Loss of SIRT7 is associated with Impairment of Adipogenesis and increased Sirt1 (show SIRT1 ELISA Kits) Activity.
the results of our study suggest that SIRT7 is involved in protecting neurons against OGD (show FGFR1 ELISA Kits)/R-induced injury, possibly through regulation of the p53 (show TP53 ELISA Kits)-mediated proapoptotic signaling pathway, indicating a potential therapeutic target for cerebral ischemia/reperfusion injury.
Histological analysis revealed that there is no apparent structural abnormality of the amygdala and hippocampus, which are regions involved in fear memory consolidation, in Sirt7 KO mice. Our results indicate that SIRT7 is involved in the consolidation of fear memory.
Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 (show SIRT4 ELISA Kits) and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 (show TDO2 ELISA Kits) and Nnmt (show NNMT ELISA Kits)); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 (show TDO2 ELISA Kits) and Nnmt (show NNMT ELISA Kits) may serve as markers of HFD consumption. (Tdo2 (show TDO2 ELISA Kits) = tryptophan 2,3-dioxygenase (show TDO2 ELISA Kits); Nnmt (show NNMT ELISA Kits) = nicotinamide N-methyltransferase (show NNMT ELISA Kits))
The Sirt7 mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (show DNMT1 ELISA Kits) and another member of the sirtuin (show SIRT1 ELISA Kits) family, Sirt1 (show SIRT1 ELISA Kits).
These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 (show HIST3H3 ELISA Kits) K18 (show KRT18 ELISA Kits) deacetylation and the maintenance of genome integrity.
miR (show MLXIP ELISA Kits)-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.
The role of SIRT7 has emerged in protein synthesis, chromatin remodelling, cellular survival and lipid metabolism.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
, sirtuin 7
, novel protein similar to vertebratesirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) (SIRT7)
, NAD-dependent deacetylase sirtuin-7
, NAD-dependent protein deacetylase sirtuin-7
, SIR2-like protein 7
, regulatory protein SIR2 homolog 7
, silent mating type information regulation 2, S.cerevisiae, homolog 7
, sir2-related protein type 7
, sirtuin type 7
, NAD-dependent deacetylase sirtuin 7