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Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Additionally we are shipping SNRNP70 Antibodies (46) and SNRNP70 Proteins (8) and many more products for this protein.
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These findings provide evidence for a new role of a general small nuclear ribonucleoprotein (show RBP31 ELISA Kits) particle protein, U1C (show SNRPC ELISA Kits), as a mediator of alternative splicing regulation.
These results indicate that the galectin-3 (show LGALS3 ELISA Kits)-U1 snRNP-pre-mRNA ternary complex is a functional E complex and that U1 snRNP is required to assemble galectin-3 (show LGALS3 ELISA Kits) onto an active spliceosome
The epitopes of U1-70K autoantibodies have been mapped at single-amino acid resolution.
The authors propose that Gemin2 (show GEMIN2 ELISA Kits) is a versatile hub for ribonucleoprotein (show RBP31 ELISA Kits) exchange that functions broadly in RNA metabolism.
data lead to a model that FUS functions in coupling transcription to splicing via mediating an interaction between RNAP II and U1 snRNP
The selection of 5'-splice site nucleotides by U1 snRNP is achieved predominantly through basepairing with U1 snRNA whilst U1-C (show SNRPC ELISA Kits) fine-tunes relative affinities of mismatched 5'-splice sites.
methylation of snRNP70 by SETMAR (show SETMAR ELISA Kits) regulates constitutive and/or alternative splicing
U1-70K interacts with the SMN (show STMN1 ELISA Kits) complex and is required for nuclear gem (show GEM ELISA Kits) integrity.
Data indicate that small nuclear ribonucleoprotein (show RBP31 ELISA Kits) U1-70K in Alzheimer disease (AD) may directly sequester normal soluble forms of U1-70K into insoluble aggregates.
These studies identify U1 snRNP pathologic changes in brain of early onset genetic forms of Alzheimer's disease
inhibition of U1 snRNP also leads to regulation of the usage of In3 pA, suggesting that the C/P activity in the cell can be cross-regulated by splicing, leading to coordination between these two processes.
Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
U1 small nuclear ribonucleoprotein 70 kDa
, U1 snRNP 70 kDa
, small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)
, small nuclear ribonucleoprotein 70kDa (U1)
, U1 small nuclear ribonucleoprotein polypeptide A
, U1 small ribonucleoprotein 70kd
, small nuclear ribonucleoprotein 70kDa
, U1 small nuclear ribonucleoprotein 70 kDa polypeptide A