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SMG6 encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of SMG6 also participates in the nonsense-mediated mRNA decay (NMD) pathway. Additionally we are shipping SMG6 Kits (2) and and many more products for this protein.
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Smg6/Est1 (show AP1S2 Antibodies) licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.
Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture.
Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.
A preferred sequence motif spanning most SMG6 cleavage sites has been discovered by analysis of endogenous non-sense-mediated mRNA decay targets.
SMG6 requires UPF1 (show UPF1 Antibodies) and SMG1 (show SMG1 Antibodies) for nonsense-mediated mRNA decay.
The study demonstrates that SMG5 (show SMG5 Antibodies)-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 (show UPF1 Antibodies) recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network.
Consistent with involvement of SMG6 in the decay process full-length nonsense-containing beta-globin (show HBB Antibodies) mRNA was increased and the Delta169 decay intermediate was decreased in cells knocked down for SMG6.
The tricotetrapeptide repeat-containing domain within Est1A was sufficient for interaction with hTERT.
Data show that SMG6 interacts directly with the EJC via two conserved EJC-binding motifs (EBMs).
Human EST1A is associated with most or all active telomerase and is involved either directly or indirectly in telomere elongation and telomere capping.
Structural properties of the PIN (show DYNLL1 Antibodies) domain indicate its putative active center consisting of invariant acidic amino acid residues, which is similar to the active center of 5' nucleases.
This gene encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of this gene also participates in the nonsense-mediated mRNA decay (NMD) pathway. The encoded protein contains two binding sites for components of the exon junction complex (EJC)\; interaction between the encoded protein and the EJC is necessary for NMD activity. Multiple transcript variants encoding different isoforms have been found for this gene.
EST1-like protein A
, ever shorter telomeres 1A
, telomerase subunit EST1A
, telomerase-binding protein EST1A
, EST1 telomerase component homolog A
, smg-6 homolog, nonsense mediated mRNA decay factor