Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans) (SMG7) ELISA Kits

SMG7 encodes a protein that is essential for nonsense-mediated mRNA decay (NMD)\; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. Additionally we are shipping SMG7 Antibodies (27) and SMG7 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse SMG7 SMG7 226517 Q5RJH6
SMG7 9887 Q92540
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Top SMG7 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human
  96 Tests Log in to see 2 to 3 Days
$380.00
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More ELISA Kits for SMG7 Interaction Partners

Human Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans) (SMG7) interaction partners

  1. Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6 (show SMG6 ELISA Kits)-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6 (show SMG6 ELISA Kits)- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 (show SMG6 ELISA Kits) and SMG7 degrade NMD substrates is determined by the mRNA architecture.

  2. Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6 (show SMG6 ELISA Kits)- and SMG7-mediated degradation pathways.

  3. Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5, and Smg7 led to increased levels of viral proteins and and virus release.

  4. The study demonstrates that SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network.

  5. Data show that phosphorylated hUPF1, the human ortholog of UPF1/SMG-2, forms a complex with human orthologs of the Caenorhabditis elegans proteins SMG-5 and SMG-7.

SMG7 Antigen Profile

Antigen Summary

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD)\; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with SMG7

  • Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) (Smg7) antibody
  • SMG7, nonsense mediated mRNA decay factor (SMG7) antibody
  • 9430023P16Rik antibody
  • C1orf16 antibody
  • EST1C antibody
  • mKIAA0250 antibody
  • SGA56M antibody

Protein level used designations for SMG7

EST1-like protein C , protein SMG7 , EST1 telomerase component homolog C , breast cancer-associated antigen SGA-56M , ever shorter telomeres 1C , smg-7 homolog, nonsense mediated mRNA decay factor

GENE ID SPECIES
226517 Mus musculus
9887 Homo sapiens
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