Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
SMG7 encodes a protein that is essential for nonsense-mediated mRNA decay (NMD)\; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. Additionally we are shipping SMG7 Antibodies (27) and SMG7 Proteins (4) and many more products for this protein.
Showing 1 out of 1 products:
Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6 (show SMG6 ELISA Kits)-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6 (show SMG6 ELISA Kits)- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 (show SMG6 ELISA Kits) and SMG7 degrade NMD substrates is determined by the mRNA architecture.
Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6 (show SMG6 ELISA Kits)- and SMG7-mediated degradation pathways.
Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5, and Smg7 led to increased levels of viral proteins and and virus release.
The study demonstrates that SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network.
Data show that phosphorylated hUPF1, the human ortholog of UPF1/SMG-2, forms a complex with human orthologs of the Caenorhabditis elegans proteins SMG-5 and SMG-7.
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD)\; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
EST1-like protein C
, protein SMG7
, EST1 telomerase component homolog C
, breast cancer-associated antigen SGA-56M
, ever shorter telomeres 1C
, smg-7 homolog, nonsense mediated mRNA decay factor