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SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]..
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Human Polyclonal SNAI3 Primary Antibody for IHC, IHC (p) - ABIN4354873
Gras, Jacqueroud, Wierinckx, Lamblot, Fauvet, Lachuer, Puisieux, Ansieau: Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells. in PLoS ONE 2014
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SNAI1 (show SNAI1 Antibodies), SNAI2, SNAI3 show unequal oncogenic potential, strictly correlating with their ability to promote epithelial-to-mesenchymal transition.
using global gene expression analysis of partially reprogrammed cells, we identified SNAI3 as a novel invasion-related marker in human melanoma. SNAI3 expression correlates with tumor thickness in primary melanomas and thus, may be of prognostic value
The data presented here demonstrate that Snai2 and Snai3 transcriptionally regulate the cellular fitness and functionality of not only CD4 (show CD4 Antibodies)(+) regulatory T cells but effector CD8(alpha+) and CD4 (show CD4 Antibodies)(+) conventional T cells as well.
Data indicate that deletion of snail (show SNAI1 Antibodies) family transcription factors Snai2 and Snai3 in bone marrow-derived cells is sufficient to induce autoantibody generation.
Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency.
Snai3 gene function is not essential for embryogenesis in mice.
overexpression of Snai3 does alter bone marrow cell development
Snail (show SNAI1 Antibodies) genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication
Expression of Snai3 was studied during mouse development.
Snail (show SNAI1 Antibodies) is present in activated mesenchymal cells indicating its relevance in the communication between tumor and stroma and suggest that it can promote the conversion of carcinoma cells to stromal cells.
These data implicate Smuc as blocking Pactolus transcription in cells expressing PU.1 (and CD18) but not Pactolus.
SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003
protein snail homolog 3
, snail homolog 3
, zinc finger protein 293
, zinc finger protein SNAI3
, snail-related gene from muscle cells
, snail-related protein 2