anti-Sodium Channel, Voltage-Gated, Type II, beta (SCN2B) Antibodies

forms a voltage gated sodium channel with alpha subunit\; may modulate sodium channel expression in neurons [RGD, Feb 2006].. Additionally we are shipping SCN2B Proteins (10) and SCN2B Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN2B 6327 O60939
SCN2B 25349 P54900
SCN2B 72821 Q56A07
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Top anti-SCN2B Antibodies at antibodies-online.com

Showing 10 out of 121 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB Western blot analysis of SCN2B expression in HEK293T (A), Raw264.7 (B), rat liver (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry-Paraffin: Scn2b Antibody [NBP1-39493] - Analysis of anti-SCN2B antibody with human brain, cortex at concentration 20 ug/ml. 0.05 mg Log in to see 10 to 13 Days
$559.35
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with SCN2B antibody ABIN337345 at 10-20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-SCN2B antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6275578 staining 293 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse HRP ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav beta 2 Monoclonal Antibody, Clone S395-68 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Nav beta 2 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Nav beta 2 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~40 kDa Nav-Beta-2 protein using Mouse Anti-Nav-Beta-2 Monoclonal Antibody, Clone S395-68 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Nav-Beta-2 Monoclonal Antibody at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~40 kDa. 100 μg Log in to see 3 to 4 Days
$499.20
Details
Human Mouse FITC ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav beta 2 Monoclonal Antibody, Clone S395-68 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Nav beta 2 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Nav beta 2 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~40 kDa Nav-Beta-2 protein using Mouse Anti-Nav-Beta-2 Monoclonal Antibody, Clone S395-68 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Nav-Beta-2 Monoclonal Antibody at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~40 kDa. 100 μg Log in to see 3 to 4 Days
$504.40
Details
Human Mouse Alkaline Phosphatase (AP) ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav beta 2 Monoclonal Antibody, Clone S395-68 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Nav beta 2 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Nav beta 2 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~40 kDa Nav-Beta-2 protein using Mouse Anti-Nav-Beta-2 Monoclonal Antibody, Clone S395-68 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Nav-Beta-2 Monoclonal Antibody at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~40 kDa. 100 μg Log in to see 3 to 4 Days
$507.00
Details
Human Mouse Biotin ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav beta 2 Monoclonal Antibody, Clone S395-68 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Nav beta 2 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Nav beta 2 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~40 kDa Nav-Beta-2 protein using Mouse Anti-Nav-Beta-2 Monoclonal Antibody, Clone S395-68 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Nav-Beta-2 Monoclonal Antibody at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~40 kDa. 100 μg Log in to see 3 to 4 Days
$509.60
Details
Human Mouse PE ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav beta 2 Monoclonal Antibody, Clone S395-68 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Nav beta 2 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Nav beta 2 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~40 kDa Nav-Beta-2 protein using Mouse Anti-Nav-Beta-2 Monoclonal Antibody, Clone S395-68 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Nav-Beta-2 Monoclonal Antibody at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~40 kDa. 100 μg Log in to see 3 to 4 Days
$510.90
Details
Human Mouse Streptavidin ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav beta 2 Monoclonal Antibody, Clone S395-68 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Nav beta 2 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Nav beta 2 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~40 kDa Nav-Beta-2 protein using Mouse Anti-Nav-Beta-2 Monoclonal Antibody, Clone S395-68 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Nav-Beta-2 Monoclonal Antibody at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~40 kDa. 100 μg Log in to see 3 to 4 Days
$512.20
Details

More Antibodies against SCN2B Interaction Partners

Human Sodium Channel, Voltage-Gated, Type II, beta (SCN2B) interaction partners

  1. Findings add to the understanding of beta2 role in Nav 1.5 trafficking and localisation, which must influence cell excitability and electrical coupling in the heart.

  2. The authors identified a flexible loop formed by (72)Cys and (75)Cys, a unique feature among the four beta-subunit isoforms.

  3. Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome.

  4. In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes.

  5. With increased beta-2 expression, prostate cancer cells display a trend of enhanced association with nerve axons.

  6. sodium channel polymorphisms are associated with epilepsy

  7. SCN2B is a new candidate gene associated with Brugada syndrome.

  8. beta2 is a PS/gamma-secretase substrate, gamma-secretase mediated cleavage of beta2-C-terminal fragment is required for cell-cell adhesion and migration of beta2-expressing cells

Mouse (Murine) Sodium Channel, Voltage-Gated, Type II, beta (SCN2B) interaction partners

  1. Genetic deletion of Scn2b in mice results in ventricular and atrial arrhythmias, consistent with reported SCN2B mutations in human patients.

  2. SCN2B could play an important role in the aging-related cognitive deterioration, which is associated with the regulations of COX5A and FGF-2.

  3. This study demonistrated that scn2b gene expression in mouse dorsal raphe nucleus

  4. beta2 is a PS/gamma-secretase substrate, gamma-secretase mediated cleavage of beta2-C-terminal fragment is required for cell-cell adhesion and migration of beta2-expressing cells

  5. Increased beta2 subunit expression in sensory neurons after nerve injury is functionally significant. Development of mechanical allodynia-like behavior in the SNI model is attenuated in beta2 subunit null mutant mice.

  6. Data suggest that loss of sodium channel beta2 subunit is neuroprotective in experimental allergic encephalomyelitis by prevention of Na+ channel up-regulation in response to demyelination.

SCN2B Antigen Profile

Protein Summary

forms a voltage gated sodium channel with alpha subunit\; may modulate sodium channel expression in neurons

Gene names and symbols associated with SCN2B

  • sodium voltage-gated channel beta subunit 2 (SCN2B) antibody
  • sodium voltage-gated channel beta subunit 2 (Scn2b) antibody
  • sodium channel, voltage-gated, type II, beta (Scn2b) antibody
  • sodium voltage-gated channel beta subunit 2 L homeolog (scn2b.L) antibody
  • sodium channel, voltage-gated, type II, beta (scn2b) antibody
  • sodium voltage-gated channel beta subunit 2 (scn2b) antibody
  • 2810451E09Rik antibody
  • AI840361 antibody
  • Gm183 antibody
  • SCN2B antibody
  • SCNB2 antibody

Protein level used designations for SCN2B

neuronal voltage-gated sodium channel beta 2 subunit , sodium channel beta 2 subunit , sodium channel subunit beta-2 , sodium channel, voltage-gated, type II, beta polypeptide , Sodium channel beta 2 , cardiomyocyte sodium channel beta-2 subunit , sodium channel, voltage-gated, type II, beta , sodium voltage-gated channel type II beta , voltage-gated sodium channel beta 2 subunit

GENE ID SPECIES
6327 Homo sapiens
25349 Rattus norvegicus
72821 Mus musculus
403485 Canis lupus familiaris
419776 Gallus gallus
466796 Pan troglodytes
494804 Xenopus laevis
538722 Bos taurus
678698 Macaca mulatta
777666 Danio rerio
100144663 Xenopus (Silurana) tropicalis
100352300 Oryctolagus cuniculus
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