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The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. Additionally we are shipping Sodium Dependent Vitamin C Transporter 1 Antibodies (29) and Sodium Dependent Vitamin C Transporter 1 Kits (6) and many more products for this protein.
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Our findings show, for the first time, that transporters of the water-soluble vitamin ascorbic acid (i.e., the vitamin C transporters SVCT-1 and SVCT-2 (show SLC23A2 Proteins)) are differentially expressed along the length of the intestinal tract and that the pattern of expression is mediated, at least in part, by transcriptional and epigenetic mechanism(s) affecting both Slc23a1 (show SLC23A2 Proteins) and Slc23a2 (show SLC23A2 Proteins) genes.
consensus site for HNF1 (show HNF1A Proteins) that is crucial for the regulation of the human SVCT1 promoter is present in the SVCT1 rat promoter but has no effect on its transcriptional activity
SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. results add to previous reports vitamin C plays a role in pathogenesis of periodontitis.
Data from observational/genetic association studies in Europe suggest an SNP in SLC23A1 (show SLC23A2 Proteins) (rs33972313) is associated with up-regulation of circulating L-ascorbic acid but not with any cardiometabolic/cardiovascular outcome investigated. [META-ANALYSIS]
The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells.
polymorphisms in SLC23A1 (show SLC23A2 Proteins)/2 genes influenced ascorbate concentration in aqueous humor and lens nucleus.
A genetic variant in the SLC23A1 (show SLC23A2 Proteins) ascorbate transporter locus was identified and is associated with an increased risk of Crohn disease in a white Canadian inflammatory bowel diseases cohort.
Data show that the mRNA level of svct2 (show SLC23A2 Proteins) was approximately 600- to 900-fold higher than that of svct1 indicating SVCT2 (show SLC23A2 Proteins) is a main isoform in fibroblast OUMS-36 cells, and no significant difference in svct2 (show SLC23A2 Proteins) mRNA and protein between young and old cells.
Data suggest that N-terminal and C-terminal sorting signals interact, directly or indirectly, within each gene family (here, SVCT1 and SVCT2 (show SLC23A2 Proteins)) in basolateral targeting of transmembrane proteins to basolateral cell membrane.
SVCT1 directly interacts with GRHPR (show GRHPR Proteins).
Aging modulates vitamin C transporter expression. Renal over-expression of SVCT1 enhances vitamin C reabsorption in aged animals that may synthesize less vitamin C.
a key role for Slc23a1 in renal ascorbate absorption and perinatal survival and reveal regulation of vitamin C biosynthesis in mice.
By using primary cultured hepatocytes from SMP30/GNL (show RGN Proteins) KO mice, we found that SVCT1 and SVCT2 (show SLC23A2 Proteins) mRNA expression levels and AA uptake ability were significantly enhanced in the hepatocytes of ascorbic acid-depleted SMP30/GNL (show RGN Proteins) KO mice.
SVCT2 (show SLC23A2 Proteins) is major determinant of ascorbate accumulation in tissues lacking SVCT1. SVCT isoforms appear to function independently of one another. SVCT1 expression and ascorbate concentrations in SVCT1-predominant organs were not affected by SVCT2 (show SLC23A2 Proteins) deficiency.
SVCT1 is responsible for epidermal ascorbic acid supply, whereas SVCT2 (show SLC23A2 Proteins) mainly facilitates ascorbic acid transport in the dermal compartment
PPARalpha (show PPARA Proteins) up-regulates the expression of Slc23a1 in small intestine.
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Na(+)/L-ascorbic acid transporter 1
, sodium-dependent vitamin C transporter 1
, sodium-dependent vitamin C transporter-1
, solute carrier family 23 (nucleobase transporters), member 1
, solute carrier family 23 (nucleobase transporters), member 2
, solute carrier family 23 member 1
, yolk sac permease-like molecule 3
, sodium-coupled ascorbic acid transporter 1
, sodium-coupled ascorbic acid transporter 1