anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7) Antibodies

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. Additionally we are shipping SLC12A7 Proteins (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC12A7 10723 Q9Y666
SLC12A7 308069 Q5RK27
SLC12A7 20499 Q9WVL3
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Top anti-SLC12A7 Antibodies at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 6 to 7 Days
$291.53
Details
Human Rabbit Un-conjugated WB WB Image Sample(30 μg of whole cell lysate) A:H1299 7.5% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated IHC (p), WB SLC12A7 Antibody (N-term)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SLC12A7 antibody detected the SLC12A7 protein (arrow). SLC12A7 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC12A7 Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Alexa Fluor 647 FACS Detection of KCC4/SLC12A7 in HEK293 Human Cell Line Transfected with Human SLC12A7 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) human SLC12A7 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Human KCC4/SLC12A7 Alexa Fluor 647-conjugated Monoclonal Antibody. 25 Tests Log in to see 8 to 9 Days
$189.84
Details
Human Mouse Un-conjugated CyTOF, FACS Detection of KCC4/SLC12A7 in HEK293 Human Cell Line Transfected with Human SLC12A7 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) human SLC12A7 or (B) human MRGPRF and eGFP was stained with Mouse Anti-Human KCC4/SLC12A7 Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$238.43
Details
Hamster Goat Un-conjugated ELISA   100 μg Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 11 to 14 Days
$1,123.83
Details
Mouse Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 11 to 14 Days
$1,123.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using SLC12A7 antibody. 200 μL Log in to see 12 to 14 Days
$438.90
Details

Top referenced anti-SLC12A7 Antibodies

  1. Human Polyclonal SLC12A7 Primary Antibody for ELISA - ABIN449541 : Simard, Bergeron, Frenette-Cotton, Carpentier, Pelchat, Caron, Isenring: Homooligomeric and heterooligomeric associations between K+-Cl- cotransporter isoforms and between K+-Cl- and Na+-K+-Cl- cotransporters. in The Journal of biological chemistry 2007 (PubMed)

More Antibodies against SLC12A7 Interaction Partners

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7) interaction partners

  1. SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior

  2. SLC12A7 gene amplification and overexpression occurs frequently in adrenocortical carcinoma and may play a role in adrenocortical carcinoma tumorigenesis.

  3. The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1/2 and NCC were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

  4. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 that could result in modulation of KCC activity

  5. Negative stain transmission electron microscopy and single particle analysis of KCC4 and the aquaporin-1 AQP1 water channel, revealed the expected quaternary structures within homogeneous preparations, and thus correct protein folding and assembly.

  6. analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4

  7. human osteoblasts express functional K-Cl cotransporters in their cell membrane that seem to be able to induce the indirect activation of volume-sensitive Cl- channels by KCl through an increase in the intracellular ions, water influx and cell swelling.

  8. KCC activation by IGF-1 plays an important role in IGF-1 signaling to promote growth and spread of gynecological cancers.

  9. Among patients with early-stage node-negative breast cancer, disease-free survival (DFS) and overall survival (OS) curves were significantly different based on IGF-1 and KCC expression.

  10. KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state.

  11. In the metastatic cancer tissues, KCC4 colocalizes with IGF-I or EGF.

  12. Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown.

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7) interaction partners

  1. During cell swelling PP1alpha and PP1gamma1 are involved in KCC4 regulation by WNK4, but that the kinase acts upon these phosphatases to inhibit their activity.

  2. Data are consistent with a role for KCC4 in salt reabsorption of the thick ascending loop of Henle's loop and acid secretion of the collecting duct.

  3. We propose that glycosylation is essential for the surface expression, stabilization, and bioactivity of KCC4

  4. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 that could result in modulation of KCC activity

  5. Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown.

  6. Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1) with the cotransporters KCC3, NKCC1, and NKCC2 but not KCC1 and KCC4

  7. all of the CCCs examined (NKCC1, NKCC2, KCC1, KCC3, and KCC4) can promote NH4(+) translocation, presumably through binding of the ion at the K(+) site

  8. KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state.

SLC12A7 Antigen Profile

Protein Summary

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).

Gene names and symbols associated with SLC12A7

  • solute carrier family 12 (potassium/chloride transporters), member 7 (SLC12A7) antibody
  • solute carrier family 12 member 7 (SLC12A7) antibody
  • solute carrier family 12 member 7 (Slc12a7) antibody
  • solute carrier family 12, member 7 (Slc12a7) antibody
  • AA408796 antibody
  • D13Ertd261e antibody
  • Kcc4 antibody
  • Slc12a5 antibody
  • SLC12A7 antibody

Protein level used designations for SLC12A7

solute carrier family 12 (potassium/chloride transporters), member 7 , K-Cl cotransporter 4 , electroneutral potassium-chloride cotransporter 4 , potassium/chloride transporter KCC4 , solute carrier family 12 member 7 , K-Cl cotransporter KCC4 , furosemide-sensitive KCl cotransporter 4 , potassium-chloride cotransporter

GENE ID SPECIES
528038 Bos taurus
709581 Macaca mulatta
10723 Homo sapiens
308069 Rattus norvegicus
100008847 Oryctolagus cuniculus
20499 Mus musculus
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