Solute Carrier Family 22 (Organic Cation Transporter), Member 7 (SLC22A7) ELISA Kits

Human Solute Carrier Family 22 (Organic Cation Transporter), Member 7 (SLC22A7) interaction partners

1. SLC22A7 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.

2. Two novel variants in SLC22A17 and SLC22A7 were significantly associated with anthracycline-induced cardiotoxicity.

3. suggest that OAT2-mediated cGMP uptake does not occur via exchange with monocarboxylates, dicarboxylates, and hydroxyl ions

4. the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine

5. At physiologic creatinine concentrations, specific activity of OAT2 transport was over twofold higher than OCT2 or OCT3 (show POU5F1 ELISA Kits), establishing OAT2 as a likely creatinine transporter, challenging the view that creatinine is solely transported by a cationic pathway

6. mitochondrial pathways may affect SLC (show CCL21 ELISA Kits) 22A7 function to promote the occurrence of hepatocellular carcinoma

7. Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate (show GRIN1 ELISA Kits) at OAT2

8. Transport of the antivirals into human embryonic kidney cells was stimulated 10- to 20-fold by expression of OAT2.

9. Expression of rat OAT2 in HEK (show EPHA3 ELISA Kits) (human embryonic kidney)-293 cells stimulates accumulation of zwitterion trigonelline; subsequently, orotic acid is identified as an excellent and specific substrate of OAT2 from human.

10. results suggest that genetic polymorphisms may not be a significant contributing factor to variations in the hOAT2 expression or hOAT2 transport activity

Mouse (Murine) Solute Carrier Family 22 (Organic Cation Transporter), Member 7 (SLC22A7) interaction partners

1. there exists a sex- and species-related differential gene expression of the OAT2 isoform.

2. Results indicate that mOAT2 plays a role for the transport of bumetanide on the luminal membranes of kidney proximal tubules.

3. OAT2 in mouse kidney exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation

4. propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner.