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Calcium-dependent mitochondrial solute carrier. Additionally we are shipping Solute Carrier Family 25 (Mitochondrial Carrier, Phosphate Carrier), Member 23 Proteins (6) and and many more products for this protein.
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direct measurements of Mg(2+), Mn(2+), Fe(2+), Zn(2+) and Cu(2+) showed that they are cotransported with ATP by both hAPCs and AtAPCs. It is likely that in vivo APCs transport free ATP and ATP-Mg complex to different degrees, and probably trace amounts of other Metals(2+) in complex with ATP.
Our results showed EZH2 to be highly overexpressed in astrocytic tumors with a significant positive correlation with grade.we identified SLC25A23 as important target of H3K27me3 modification, which was downregulated in GBM and its low expression was associated with poor prognosis in glioblastomas (GBMs).
SLC25A23 augments mitochondrial Ca(2) uptake, interacts with MCU, and induces oxidative stress-mediated cell death.
Compares and contrasts all the known human SLC25A* genes and includes functional information.
SCaMC-3 is a member of a novel human subfamily of mitochondrial carriers with calcium-binding domains
identification of three isoforms of the mitochondrial ATP-Mg/Pi carrier APC1, APC2 and APC3; they are most likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria
Northern blot analysis reveals the presence of the transcript in brain, heart, skeletal muscle, liver and small intestine. The SLC25A23 gene undergoes alternative splicing suggesting a modular nature of the encoded product.
SCaMC-3 KO neurons have higher vulnerability to in vitro excitotoxicity, and SCaMC-3 KO mice are more susceptible to kainate-induced seizures.
Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity).
calcium-binding mitochondrial carrier protein SCaMC-3
, phosphate carrier), member 23
, mitochondrial ATP-Mg/Pi carrier protein 2
, mitochondrial Ca(2+)-dependent solute carrier protein 2
, mitochondrial Ca2+-dependent solute carrier protein 2
, short calcium-binding mitochondrial carrier 3
, small calcium-binding mitochondrial carrier protein 3
, solute carrier family 25 member 23