anti-Solute Carrier Family 26, Member 3 (SLC26A3) Antibodies

The protein encoded by SLC26A3 is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. Additionally we are shipping SLC26A3 Proteins (6) and SLC26A3 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC26A3 1811 P40879
SLC26A3 13487 Q9WVC8
SLC26A3 114629 Q924C9
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Top anti-SLC26A3 Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Host: Rabbit Target Name: SLC26A3 Sample Type: HepG2 Antibody Dilution: 1.0ug/ml  SLC26A3 is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit Anti-SLC26A3 Antibody  Catalog Number: ARP31608_P050 Formalin Fixed Paraffin Embedded Tissue: Human Adult heart  Observed Staining: Membrane Primary Antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 – 2.0 sec Protocol located in Reviews and Data. 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see Available
$363.46
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 2 to 3 Days
$446.88
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to SLC26A3 on formalin-fixed paraffin-embedded human spleen. [antibody concentration 1.8 ug/ml] Detection limit for recombinant GST tagged SLC26A3 is 0.3 ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$364.00
Details
Human Rabbit Un-conjugated ELISA, WB 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 11 to 13 Days
$335.04
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.89 KDa) . 50 μL Log in to see 11 to 12 Days
$238.67
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Mouse Un-conjugated IHC, ELISA, WB   100 μg Log in to see 11 to 16 Days
$625.43
Details

Top referenced anti-SLC26A3 Antibodies

  1. Human Monoclonal SLC26A3 Primary Antibody for IHC (p), ELISA - ABIN560647 : Abdulnour-Nakhoul, Nakhoul, Kalliny, Gyftopoulos, Rabon, Doetjes, Brown, Nakhoul: Ion transport mechanisms linked to bicarbonate secretion in the esophageal submucosal glands. in American journal of physiology. Regulatory, integrative and comparative physiology 2011 (PubMed)

More Antibodies against SLC26A3 Interaction Partners

Human Solute Carrier Family 26, Member 3 (SLC26A3) interaction partners

  1. role in protecting the intestinal epithelial barrier

  2. study found that the rs2108225 variation in SLC26A3 might increase the risk of ulcerative colitis (UC) and affect its expression at both the mRNA and protein levels in colonic tissues of patients with UC; the rs17154444 variation might influence the severity of UC

  3. TNFalpha may act reciprocally with DRA, leading to the development of intestinal inflammation.

  4. Results indicate the involvement of SLC26A3 along with SLC26A6 in transporting HCO3(-) essential for embryo cleavage, possibly working in concert with CFTR through a Cl(-) recycling pathway.

  5. This study confirms the molecular heterogeneity of sporadic congenital chloride diarrhea, adding 12 novel SLC26A3 mutations to the list of known pathogenic mutations.

  6. Molecular analysis of human solute carrier SLC26A2, SLC26A3, and SLC26A4 anion transporter disease-causing mutations using 3-dimensional homology modeling has been presented.

  7. In intestinal cells, TNF activates NF-kappaB, which reduces expression of the Cl(-) / HCO3(-) exchanger SLC26A3, via direct binding to the promoter region.

  8. Genetic variations of the SLC26A3 rs2108225 is associated with enhance the risk of ulcerative colitis.

  9. We report the first Tunisian case of SLC26A3 gene mutation in congenital chloride diarrhea. Our patient was homozygous for G187X mutation. Both parents were heterozygous for the same mutation.

  10. Expression of NHE3 and DRA was reduced with high tacrolimus levels and impaired renal function after intestinal transplantation.

  11. A variety of mutations in SLC26A3 are responsible for CCD. A total of 55 mutations in SLC26A3 have been reported

  12. Data demonstrate an upregulation of SLC26A3 via activation of the ERK1/2 pathway that may underlie potential antidiarrheal effects of Bifidobacterium sp.

  13. Efficacy of lactobacillus acidophilus or its secreted soluble factors in alleviating inflammation and inflammation-associated dysregulation of DRA activity could justify their therapeutic potential in inflammatory diarrheal diseases.

  14. The SLC26A3-NHERF4 interaction was modulated by phosphorylation; serine 329 of NHERF4-PDZ3 played a critical role in modulating binding selectivity.

  15. few patients develop illnesses because of SLC26A3 mutations.

  16. Slc26a3 contributes to sulfate secretion via DIDS-senstive bicarbonate-sulfate exchange in addition to being the principal DIDS-resistant chloride-bicarbonate exchanger.

  17. This is the first report to demonstrate the genetic background of congenital chloride diarrhea in a single ethnic group of East Asian descent (Korean). The c.2063-1G>T mutation wa found in at least one allele of all patients.

  18. these data indicate that N-glycosylation of SLC26A3 is important for cell surface expression and for protection from proteolytic degradation that may contribute to the understanding of pathogenesis of congenital disorders of glycosylation.

  19. Data from pediatric patients with congenital chloride diarrhea identifies 7 novel mutations in SLC26A3, including 3 missense changes of highly conserved residues.

  20. This review summarizes the current knowledge of SLC26A3 mutations and polymorphisms in congenital chloride diarrhea. [Review]

Mouse (Murine) Solute Carrier Family 26, Member 3 (SLC26A3) interaction partners

  1. role in protecting the intestinal epithelial barrier

  2. TNFalpha may act reciprocally with DRA, leading to the development of intestinal inflammation.

  3. In intestinal cells, TNF activates NF-kappaB, which reduces expression of the Cl(-) / HCO3(-) exchanger SLC26A3, via direct binding to the promoter region.

  4. This study showed that transepithelial sulfate fluxes across the mouse distal ileum demonstrating that DRA (and to a lesser extent, PAT1) secretes sulfate with significant implications for intestinal sulfate absorption and overall homeostasis.

  5. expressed in ameloblasts but not alone critical for formation of dental enamel

  6. DRA surface expression was reduced partly via an increase in DRA endocytosis and a decrease in exocytosis

  7. Both PAT-1 and DRA significantly contribute to intestinal fluid absorption and enterocyte acid/base balance but are activated by different ion gradients.

  8. Data demonstrate an upregulation of SLC26A3 via activation of the ERK1/2 pathway that may underlie potential antidiarrheal effects of Bifidobacterium sp.

  9. Data indicate that solute carrier family 26, member 3 protein (Slc26a3) is expressed in male reproductive tract, and its expression pattern is related to the function.

  10. Deletion of DRA results in severely reduced colonic HCO3 (-) secretory rate, a loss of colonic fluid absorption, a lack of a firmly adherent mucus layer and a severely reduced colonic mucosal resistance to dextran sodium sulphate damage.

  11. Efficacy of lactobacillus acidophilus or its secreted soluble factors in alleviating inflammation and inflammation-associated dysregulation of DRA activity could justify their therapeutic potential in inflammatory diarrheal diseases.

  12. DRA mediates a predominance of the apical uptake of oxalate and Cl(-) absorbed in the small and large intestine of mice under short-circuit conditions.

  13. Endogenous and recombinant human/mouse Slc26a3 do not exhibit electrogenic 2Cl-/1HCO- exchange. Acute induction of Slc26a3 Cl-/HCO3- exchange is associated with secondary membrane potential changes representing homeostatic responses.

  14. This study showed a functionally active CFTR is an absolute requirement for Slc26-mediated duodenal bicarbonate secretion, but not for Slc26-mediated fluid absorption.

  15. demonstrate that the double-mutant mice present with a defect in intestinal water absorption and that Hnf1alpha and beta directly control the expression of Slc26a3.

  16. Increase in DRA promoter activity and expression may contribute to the upregulation of intestinal electrolyte absorption and might underlie the potential antidiarrheal effects of Lactobacillus acidophilus.

  17. In Slc26a6-knockout mice, a robust Slc26a3 compensatory upregulation can replace the function of Slc26a6 in pancreatic ducts.

  18. slc26a3 is the major apical chloride/base exchanger and is essential for the absorption of chloride in the colon. In addition, slc26a3 regulates colonic crypt proliferation.

  19. Dra activity contributes most basal HCO(3)(-) secretion and approximately 50% of cAMP-stimulated HCO(3)(-) secretion in duodenum

  20. Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice.

Zebrafish Solute Carrier Family 26, Member 3 (SLC26A3) interaction partners

  1. Provide evidence that SLC26 anion transporters mediate branchial chloride uptake in adult zebrafish (Danio rerio).

SLC26A3 Antigen Profile

Protein Summary

The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea.

Gene names and symbols associated with SLC26A3

  • solute carrier family 26 member 3 (SLC26A3) antibody
  • solute carrier family 26, member 3 (Slc26a3) antibody
  • solute carrier family 26 member 3 (Slc26a3) antibody
  • solute carrier family 26 (anion exchanger), member 3 (slc26a3.1) antibody
  • 9030623B18Rik antibody
  • 9130013M11Rik antibody
  • AV376035 antibody
  • CLD antibody
  • Dra antibody
  • si:dkey-31f5.2 antibody
  • SLC26A3 antibody

Protein level used designations for SLC26A3

chloride anion exchanger , down-regulated in adenoma protein , solute carrier family 26, member 3 , down-regulated in adenoma , down-regulated in adenoma DRA , solute carrier family 26 member 3 , chloride anion exchanger-like

GENE ID SPECIES
1811 Homo sapiens
13487 Mus musculus
114629 Rattus norvegicus
417700 Gallus gallus
472483 Pan troglodytes
483261 Canis lupus familiaris
512856 Bos taurus
563962 Danio rerio
701873 Macaca mulatta
100008798 Oryctolagus cuniculus
100010561 Monodelphis domestica
100170644 Sus scrofa
100399461 Callithrix jacchus
100582611 Nomascus leucogenys
100689262 Cavia porcellus
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