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SLC47A1 is located within the Smith-Magenis syndrome region on chromosome 17. Additionally we are shipping Solute Carrier Family 47, Member 1 Antibodies (49) and and many more products for this protein.
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Human SLC47A1 ELISA Kit for Sandwich ELISA - ABIN823375
Lee, Lee, Kim, Lee, Jun, Lee: Multidrug and toxic compound extrusion protein-1 (MATE1/SLC47A1) is a novel flavonoid transporter. in Journal of agricultural and food chemistry 2014
genetic association studies in population in China: Data confirm that an SNP in an intron of SLC47A1 (rs2289669) is associated with hypoglycemic response to metformin in patients with newly diagnosed type 2 diabetes; differential increases in basal GLP1 (show GCG ELISA Kits) plasma levels are also related to this SNP. (SLC47A1 = solute carrier family 47 member 1; GLP1 (show GCG ELISA Kits) = glucagon-like peptide-1 (show GCG ELISA Kits))
The impact of assay conditions on IC50 determination is negligible, kinetic characteristics differ among used test substrates, and substrate-dependent inhibition exists for MATE1 and MATE2-K, giving valuable insight into the assessment of clinically relevant MATE-mediated drug interactions in vitro.
Pazopanib inhibits OCT2, MATE1 and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity.
The 5' CpG island of SLC47A1 acts as an enhancer for SLC47A1, and DNA methylation in the CpG island plays a role in interindividual differences in hepatic SLC47A1 expression.
The combination of ENT1, MATE1 and OCT2 SNPs may serve as a predictive and prognostic marker in metastatic colorectal carcinoma patients treated with TAS-102.
MATE1 is the major transporter for the cellular uptake of imatinib and crucial for the therapeutic success in CML (show BCR ELISA Kits) patients. We suggest that the detailed analysis of MATE1 expression levels and mutations could be a predictor for the response to imatinib therapy.
This study did not identify any of these known SLC47A1 coding SNPs in the Xhosa individuals who participated in this study.
substrate identity exerts comparatively little influence on ligand interaction with MATE1.
MATE1 mRNA levels in peripheral blood cells were significantly higher in patients carrying the minor allele of rs2453579, but not rs2252281, compared to those with other genotypes
MATE1 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.
Mate1 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis.
MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum as well as in plasma membranes in the liver and intestine.
[(11)C]Metformin may be useful as a PET probe to non-invasively study the in vivo function of hepatobiliary transport and drug-drug interactions, mediated by MATE1 in future clinical investigations.
Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.
Homozygous MATE1 variant could be one of the risk factors for metformin-induced lactic acidosis.
MATE1 mediates the efflux of cisplatin and is involved in cisplatin-induced nephrotoxicity.
mMATE1 is polyspecific H(+)/(organic cation)OC exchanger. Unexpectedly wide distribution of mMATE1 suggests involvement in diverse biological functions other than excretion of OCs from the body. (Multidrug and toxin extrusion 1, MATE1)
mMATE1b is a functional variant of mMATE1 and seems to be the true counterpart to other MATE1 transporters
MATE1 mRNA levels were highest in the kidney, where male expression was higher than female.
This is the first report to demonstrate an essential role of MATE1 in systemic clearance of metformin.
MATE1 has an external COOH terminus, consistent with a 13-helix topology, which may influence transporter turnover.
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function.
, multidrug and toxin extrusion 1
, multidrug and toxin extrusion protein 1
, solute carrier family 47, member 1
, solute carrier family 47 member 1
, H+/organic cation antiporter variant 1
, H+/organic cation antiporter variant 2