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Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Additionally we are shipping SLC9A4 Antibodies (6) and many more products for this protein.
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Disruption of murine NHE4 leads to metabolic acidosis with inappropriate urinary ammonia excretion and decreases the ability of the thick ascending limb to absorb ammonia and to build the corticopapillary ammonia gradient.
NHE4, which may normally be coupled with the AE2 (show SLC4A2 Proteins) Cl-/HCO3- exchanger, is important for normal levels of gastric acid secretion, gastric epithelial cell differentiation, and development of secretory canalicular and tubulovesicular membranes
Dra (show SLC26A3 Proteins) is the major Cl(-)/HCO(3)(-) exchanger coupled with Nhe3 (show SLC9A3 Proteins) for electroneutral NaCl absorption across mammalian small intestine.
Data demonstrate functional NHE4 activity in the rat and human colon and suggest that this exchanger is capable of modulating intracellular pH over a wide pH spectrum and may play an important role in maintaining cellular pH homeostasis.
T84 human colon cells contain three isoforms of the Na+/H+ exchanger, NHE1 (show SLC9A1 Proteins), NHE2, and NHE4, but not the Cl-dependent NHE
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation.
solute carrier family 9 (sodium/hydrogen exchanger), member 4
, Na+/H+ exchanger
, solute carrier family 9 (sodium/hydrogen exchanger), member 2
, sodium/hydrogen exchanger 4-like
, Na(+)/H(+) exchanger 4
, sodium/hydrogen exchanger 4
, solute carrier family 9 member 4
, solute carrier family 9 (sodium/hydrogen exchanger)
, Solute carrier family 9 (sodium/hydrogen exchanger)
, solute carrier family 9 (sodium/hydrogen exchanger) isoform 4
, solute carrier family 9, member 4