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SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). Additionally we are shipping SP6 Antibodies (47) and many more products for this protein.
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epiprofin (Epfn, also known as Sp6) plays crucial distinct roles in these transition stages as a cell cycle regulator and a transcription factor.
Epfn preserves the balance between cell proliferation and cytodifferentiation in dental epithelial and mesenchymal cells during normal tooth development and morphogenesis.
Our data are compatible with Sp6 and Sp8 working together and in a dose-dependent manner as indispensable mediators of Wnt/betacatenin and Bmp signaling in the limb ectoderm
Epfn enhances canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in the developing dental pulp mesenchyme.
EPFN very likely functions as a modulator of WNT (show WNT2 Proteins) signaling in the limb ectoderm.
Epiprofin is a highly cell- and tissue-specific nuclear protein expressed primarily by proliferating epithelial cells of teeth, hair follicles, and limbs that may function in the development of these tissues by regulating cell growth
the Sp6 transcript possesses a first exon distinct from the epiprofin one
Epfn has multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation
Data suggest that Sp6 plays a critical role in the development of several epithelium-containing organs or appendages, possibly by regulating apoptosis.
SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000
Sp6 transcription factor
, transcription factor Sp6-like
, Kruppel-like factor 14
, krueppel-like factor 14
, transcription factor Sp6
, trans-acting transcription factor 6
, specificity protein 6