Speckle-Type POZ Protein (SPOP) ELISA Kits

SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. Additionally we are shipping Speckle-Type POZ Protein Antibodies (59) and Speckle-Type POZ Protein Proteins (11) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SPOP 8405 O43791
SPOP 20747 Q6ZWS8
SPOP 287643  
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Top Speckle-Type POZ Protein ELISA Kits at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.469 ng/mL 0.781-50 ng/mL   96 Tests Log in to see 12 to 14 Days
$630.00
Details
Mouse 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
$630.00
Details
Rabbit 0.375 ng/mL 0.625-40 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Guinea Pig 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Pig 0.469 ng/mL 0.781-50 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Chicken 0.469 ng/mL 0.781-50 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Monkey 0.469 ng/mL 0.781-50 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Rat
  96 Tests Log in to see 15 to 18 Days
$707.14
Details
Dog
  96 Tests Log in to see 15 to 18 Days
$707.14
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Cow
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details

More ELISA Kits for Speckle-Type POZ Protein Interaction Partners

Xenopus laevis Speckle-Type POZ Protein (SPOP) interaction partners

  1. Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 ELISA Kits)/Ci proteins in the Hh pathway.

Human Speckle-Type POZ Protein (SPOP) interaction partners

  1. Expression of the F133V mutation and wild-type SPOP was at much lower levels compared to that of F102C and Y87N mutations; however, at present, it is unknown if this also affects the biological activity of the SPOP protein.

  2. PD-L1 (show CD274 ELISA Kits) protein abundance is regulated by cyclin D-CDK4 (show CDK4 ELISA Kits) and the cullin 3-SPOP E3 ligase via proteasome-mediated degradation

  3. methylation status of SPOP promoter can be used as a novel epigenetic biomarker and a therapeutic target in colorectal cancer.

  4. these data highlight SPOP as an important regulator of luminal epithelial cell proliferation and c-MYC (show MYC ELISA Kits) expression in prostate physiology, identify c-MYC (show MYC ELISA Kits) as a novel bona fide SPOP substrate, and help explain the frequent inactivation of SPOP in human prostate adenocarcinoma.

  5. Results elucidate the tumor-suppressor role of SPOP in prostate cancer in which it acts as a negative regulator of BET protein stability and also provide a molecular mechanism for resistance to BET inhibitors in individuals with prostate cancer bearing SPOP mutations.

  6. SPOP mutation in endometrial cancer increased degradation of BRD2 (show BRD2 ELISA Kits), BRD3 (show BRD3 ELISA Kits) and BRD4 (show BRD4 ELISA Kits) proteins. SPOP mutation in prostate cancer increased expression of BRD2 (show BRD2 ELISA Kits), BRD3 (show BRD3 ELISA Kits) and BRD4 (show BRD4 ELISA Kits) proteins.

  7. Prostate cancer-derived SPOP mutants failed to interact with Cdc20 (show CDC20 ELISA Kits) to promote its degradation. As a result, SPOP-deficient prostate cancer cells with elevated Cdc20 (show CDC20 ELISA Kits) expression became resistant to a pharmacological Cdc20 (show CDC20 ELISA Kits) inhibitor.

  8. While wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a diffuse distribution in the nucleus. SPOP oligomerizes through its BTB and BACK domains.

  9. SPOP mutation activates both PI3K (show PIK3CA ELISA Kits)/mTOR (show FRAP1 ELISA Kits) and androgen receptor (show AR ELISA Kits) signaling, effectively uncoupling the normal negative feedback between these two pathways.

  10. SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.

Mouse (Murine) Speckle-Type POZ Protein (SPOP) interaction partners

  1. loss of Spop, but not Spopl, disrupts chondrocyte hypertrophy and osteoblast differentiation in the mouse, suggesting the requirement for Spop-mediated protein degradation in mouse skeletal development; overexpressed Spop targets both Gli3FL (show GLI3 ELISA Kits) and Gli3R for ubiquitination and degradation and Spop is an important positive regulator of Ihh (show IHH ELISA Kits) signaling and skeletal development

  2. Results demonstrate a negative role of Spop in the level and activity of Gli3 (show GLI3 ELISA Kits), Shh (show SHH ELISA Kits) signaling and ventral spinal cord patterning.

  3. Speckle-type pox virus and zinc finger (POZ) protein (SPOP) regulates endometrial stromal cell decidualization in mice and that hormones regulate the expression of SPOP. This study suggests that ubiquitination may be involved in embryonic implantation.

  4. These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.

  5. miR (show MLXIP ELISA Kits)-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.

  6. Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 ELISA Kits)/Ci proteins in the Hh pathway.

  7. similar S/T-rich motifs are present in Gli (show GLI1 ELISA Kits) proteins as well as in numerous HIB-interacting proteins and mediate Gli (show GLI1 ELISA Kits) degradation by SPOP

  8. MacroH2A1.2 binds the nuclear protein (show HEMGN ELISA Kits) Spop.

  9. Interaction of endogenous PDX-1 (show PDX1 ELISA Kits) and PCIF1 in MIN6 insulinoma (show RPS15 ELISA Kits) cells, is demonstarted.

Speckle-Type POZ Protein (SPOP) Antigen Profile

Antigen Summary

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

Gene names and symbols associated with SPOP

  • speckle type POZ protein (spop) antibody
  • speckle type BTB/POZ protein (SPOP) antibody
  • Speckle-type POZ protein (Bm1_45730) antibody
  • speckle-type POZ protein (spop) antibody
  • speckle type POZ protein S homeolog (spop.S) antibody
  • speckle-type POZ protein (Spop) antibody
  • speckle type BTB/POZ protein (Spop) antibody
  • AI315626 antibody
  • BTBD32 antibody
  • Pcif1 antibody
  • spop antibody
  • TEF2 antibody
  • zgc:64140 antibody

Protein level used designations for SPOP

speckle-type POZ protein , Speckle-type POZ protein , speckle-type POZ protein-like , HIB homolog 1 , SPOP1 , speckle-type POZ protein B , roadkill homolog 1 , PDX-1 C-terminal-interacting factor 1

GENE ID SPECIES
394599 Xenopus (Silurana) tropicalis
455106 Pan troglodytes
699711 Macaca mulatta
6104034 Brugia malayi
100390371 Callithrix jacchus
100021911 Monodelphis domestica
100056116 Equus caballus
100195374 Salmo salar
100544737 Meleagris gallopavo
100587478 Nomascus leucogenys
100005514 Danio rerio
779391 Xenopus laevis
425528 Gallus gallus
8405 Homo sapiens
480548 Canis lupus familiaris
530618 Bos taurus
20747 Mus musculus
287643 Rattus norvegicus
100343929 Oryctolagus cuniculus
100713182 Cavia porcellus
101111300 Ovis aries
100173908 Pongo abelii
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