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Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. Additionally we are shipping Spermine Oxidase Kits (20) and Spermine Oxidase Proteins (8) and many more products for this protein.
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Homodimeric and monomeric SMOXs are catalytically active, as revealed after gel staining for enzymatic activity. An engineered SMOX mutant deprived of all but two cysteine residues was prepared and characterized experimentally, resulting in a monomeric species. High-sensitivity differential scanning calorimetry of SMOX was compared with that of bovine serum amine oxidase, to analyse their thermal stability.
A novel enzyme with spermine oxidase properties in bovine liver mitochondria has been isolated and characterized.
AtPAO1 is the first plant Polyamine oxidase (show PAOX Antibodies) reported to be involved in a polyamine back-conversion pathway.
Data suggest that intermolecular disulfide bond links spermine oxidase (SMOX) molecules to form the homodimer and plays a critical role in the stabilization of the overall three-dimensional SMOX structure.
These results indicate a protective role for miR (show MLXIP Antibodies)-124 through the inhibition of SMOX-mediated DNA damage in the etiology of H. pylori-associated gastric cancer.
effect of Tat (show TAT Antibodies) on Nrf2 (show GABPA Antibodies) activation in human neuroblastoma (show ARHGEF16 Antibodies) cells and the role of NMDA receptor and spermine oxidase on Tat (show TAT Antibodies)-induced nuclear factor erythroid 2-related factor 2 (Nrf2 (show NFE2L2 Antibodies)) activation
During H. pylori infection, the enzyme spermine oxidase (SMOX) is induced, which generates hydrogen peroxide from the catabolism of the polyamine spermine, and increases gastric cancer risk.
study postulates a mechanism for SAT1 (show SAT1 Antibodies) and SMOX down-regulation by post-transcriptional activity of miRNAs.
Tat (show TAT Antibodies) was found to induce reactive oxygen species production and to affect cell viability in SH-SY5Y cells, these effects being mediated by spermine oxidase (SMO)
Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA (show S100A8 Antibodies).
each gene was associated with at least one main outcome: anxiety (SAT1 (show SAT1 Antibodies), SMS (show SMS Antibodies)), mood disorders (SAT1 (show SAT1 Antibodies), SMOX), and suicide attempts (SAT1 (show SAT1 Antibodies), OATL1 (show TBC1D25 Antibodies)).
Spermine oxidase (SMO) has a role in response to BENSpm and CPENSpm in breast tumor cells
Increased expression of spermine oxidase is associated with ulcerative colitis.
Novel evidences of the complex and critical functions carried out by spermine oxidase and spermine in the mammalian brain.
Spermine oxidase is an important regulator of muscle gene expression and fiber size.
Data (including data from studies using recombinant mutant proteins) suggest that Glu216-Ser218 is a hot spot responsible for Smox substrate specificity; Smox with mutation E216L/S218A exhibits specificity for N'-acetylspermine rather than spermine.
ROS (show ROS1 Antibodies) overexposure by mSMOX delivers an earlier adaptive response to radiation
Spermine oxidase binds spermine in a similar conformation as that observed in the yeast polyamine oxidase (show PAOX Antibodies) FMS1-spermine complex and demonstrate a major role for residues His82 and Lys367 in substrate binding and catalysis.
expression and characterization of mouse spermine oxidase
we identified a second domain that is necessary for nuclear localization of the spermine oxidase splice variant
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.
, flavin containing amine oxidase
, flavin-containing spermine oxidase
, polyamine oxidase 1
, putative cyclin G1 interacting protein