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May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity).. Additionally we are shipping Spindlin 1 Antibodies (42) and Spindlin 1 Kits (6) and many more products for this protein.
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we describe the first example of a histone code reader controlling SkM development in mice, which hints at Spin1 as a potential player in human SkM disease.
miR (show MLXIP Proteins)-489 loss facilitates malignant phenotype of glioma cells probably via SPIN1-mediated PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway.
In triple negative breast cancer (TNBC) cells the simultaneous miR (show MLXIP Proteins)-29b-1-5p down regulation and SPIN1 up-regulation can potentially be associated with TNBC malignancy.
These data indicate that miR (show MLXIP Proteins)-489 could reverse the chemoresistance of breast cancer via the PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins) pathway by targeting SPIN1.
High SPIN1 expression is associated with liposarcoma.
Spindlin1 activates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling downstream from protein arginine methyltransferase 2 (PRMT2 (show PRMT2 Proteins)) and the MLL (show MLL Proteins) complex, which together are capable of generating a specific H3 "K4me3-R8me2a" pattern.
the histone sequence is recognized in a distinct manner involving the amino terminus and a pair of arginine residues of histone H3 (show HIST3H3 Proteins), and disruption of the binding impaired stimulation of pre-RNA expression by Spindlin1
SPINDLIN1, which may be a novel substrate of the Aurora-A kinase (show AURKA Proteins), promotes cancer cell growth through WNT (show WNT2 Proteins)/TCF-4 (show TCF4 Proteins) signaling activation.
Spin1 regulates maternal transcripts post-transcriptionally and is involved in meiotic resumption
Spin1 isoform2 is a protein expressed highly in adult testis, which might be involved in spermatogenesis and could be necessary for normal sperm motility
Spin1 is essential to maintain metaphase II stage arrest, but a high level of Spin1 induces DNA damage in oocytes and embryos.
May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity).
ovarian cancer-related protein
, 30000 Mr metaphase complex
, SSEC P
, spindlin 1