anti-Spinster Homolog 2 (Drosophila) (SPNS2) Antibodies

Sphingolipid transporter required for migration of myocardial precursors. Additionally we are shipping SPNS2 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPNS2 216892 Q91VM4
SPNS2 100270678  
SPNS2 124976 Q8IVW8
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Top anti-SPNS2 Antibodies at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated WB SPNS2 Antibody (N-term)  western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SPNS2 antibody detected the SPNS2 protein (arrow). All lanes : Anti-SPNS2 Antibody (N-term) at 1:1000 dilution Lane 1: Human heart lysate Lane 2: Human kidney lysate Lane 3: Human skeletal muscle lysate Lane 4: SK-BR-3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 58 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL 10 to 11 Days
$385.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-SPNS2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other form ... 100 μL 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$532.46
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Rabbit Biotin ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit APC ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit PE ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit FITC ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

More Antibodies against SPNS2 Interaction Partners

Zebrafish Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

  1. Spinster 2 (SPNS2) was shown to act as a mediator of intracellular sphingosine-1-phosphate (S1P) release and play an important role in the regulation of S1P [Review].

  2. Toh is required for signaling by S1P(2)and is involved in the trafficking or cellular release of S1P.

  3. findings show that Spns2 in the yolk syncytial layer functions as a sphingosine-1-phosphate (S1P) transporter in S1P secretion, thereby regulating myocardial precursor migration

Mouse (Murine) Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

  1. In summary, these results suggest that Spns2 promotes pro-inflammatory polarization of microglia and may play a crucial role in Alzheimer disease pathogenesis.

  2. SPNS2 is essential for proper postnatal retinal morphogenesis.

  3. genome-wide in vivo screen identifies novel host regulators of metastatic colonization, such as Spns2

  4. results point to a broad role for Spns2-mediated S1P transport in the initiation and development of adaptive immune related disorders

  5. Spns2 expression by endothelial cells is essential for secretion of lymph S1P, while Spns2 is dispensable for RBC secretion of plasma S1P.

  6. Spns2 is an S1P transporter in vivo that plays a role in regulation not only of blood S1P but also lymph node and lymph S1P levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization.

  7. SPNS2 is the first physiological S1P transporter in mammals and is a key determinant of lymphocyte egress from the thymus.

  8. The changes in lymphocyte subpopulations in mutant Spns2 mice closely mimick the phenotypes of partial sphingosine-1-phosphate (S1P) deficiency, impaired S1P-dependent lymphocyte trafficking, and depletion of circulating lymphocytes.

  9. Spns2 functions in endothelial cells to establish the S1P gradient required for T and B cells to egress from their respective primary lymphoid organs.

  10. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

Human Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

  1. Spinster 2 (SPNS2) was shown to act as a mediator of intracellular sphingosine-1-phosphate (S1P) release and play an important role in the regulation of S1P [Review].

  2. our data demonstrate that Spns2 and S1P have a crucial effect on proximal tubular epithelial cells by regulating an inflammatory process and a subsequent fibrotic reaction, and also by influencing other tubular transporters that are involved in the pathophysiology of inflammatory and fibrotic kidney diseases.

  3. Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development

  4. In both macrophage and epithelial cell types, Spns2 was also found localized to cytoplasm and the nucleus, in line with a predicted bipartile Nuclear Localization Signal at the position aa282 of the human Spns2 sequence

  5. A novel role for Spns2 and S1P1&2 in the activation of p47(phox) and production of reactive oxygen species involved in hyperoxia-mediated lung injury.

  6. Spns2 plays key roles in regulating the cellular functions in non-small cell lung cancer (NSCLC) cells

  7. mammals. These findings indicate that Spns2 is required for normal maintenance of the endocochlear potential and hence for normal auditory function, and support a role for S1P signalling in hearing.

  8. Spns2 is an S1P transporter in vivo that plays a role in regulation not only of blood S1P but also lymph node and lymph S1P levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization.

  9. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

SPNS2 Antigen Profile

Protein Summary

Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.

Gene names and symbols associated with SPNS2

  • spinster homolog 2 (Drosophila) (SPNS2) antibody
  • spinster homolog 2 (Drosophila) (spns2) antibody
  • sphingolipid transporter 2 (SPNS2) antibody
  • spinster homolog 2 (spns2) antibody
  • spinster homolog 2 (Spns2) antibody
  • sphingolipid transporter 2 (Spns2) antibody
  • DKFZp459J1933 antibody
  • fi20h04 antibody
  • si:dkey-7b17.4 antibody
  • toh antibody
  • wu:fi20h04 antibody

Protein level used designations for SPNS2

spinster homolog 2 (Drosophila) , protein spinster homolog 2 , two of hearts , protein two of hearts , mCG6652-like , spinster-like protein , spinster2

GENE ID SPECIES
417492 Gallus gallus
568117 Danio rerio
606858 Canis lupus familiaris
613889 Bos taurus
100072726 Equus caballus
100145187 Xenopus (Silurana) tropicalis
100172034 Pongo abelii
216892 Mus musculus
100270678 Rattus norvegicus
124976 Homo sapiens
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