anti-Spinster Homolog 2 (Drosophila) (SPNS2) Antibodies

Zebrafish Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

1. Toh is required for signaling by S1P(2)and is involved in the trafficking or cellular release of S1P.

2. findings show that Spns2 in the yolk syncytial layer functions as a sphingosine-1-phosphate (S1P) transporter in S1P secretion, thereby regulating myocardial precursor migration

Mouse (Murine) Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

1. SPNS2 is essential for proper postnatal retinal morphogenesis.

2. genome-wide in vivo screen identifies novel host regulators of metastatic colonization, such as Spns2

3. results point to a broad role for Spns2-mediated S1P transport in the initiation and development of adaptive immune related disorders

4. Spns2 expression by endothelial cells is essential for secretion of lymph S1P, while Spns2 is dispensable for RBC secretion of plasma S1P.

5. Spns2 is an S1P transporter in vivo that plays a role in regulation not only of blood S1P but also lymph node and lymph S1P levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization.

6. SPNS2 is the first physiological S1P transporter in mammals and is a key determinant of lymphocyte egress from the thymus.

7. The changes in lymphocyte subpopulations in mutant Spns2 mice closely mimick the phenotypes of partial sphingosine-1-phosphate (S1P) deficiency, impaired S1P-dependent lymphocyte trafficking, and depletion of circulating lymphocytes.

8. Spns2 functions in endothelial cells to establish the S1P gradient required for T and B cells to egress from their respective primary lymphoid organs.

9. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

Human Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

1. our data demonstrate that Spns2 and S1P have a crucial effect on proximal tubular epithelial cells by regulating an inflammatory process and a subsequent fibrotic reaction, and also by influencing other tubular transporters that are involved in the pathophysiology of inflammatory and fibrotic kidney diseases.

2. Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development

3. In both macrophage and epithelial cell types, Spns2 was also found localized to cytoplasm and the nucleus, in line with a predicted bipartile Nuclear Localization Signal at the position aa282 of the human Spns2 sequence

4. A novel role for Spns2 and S1P1&2 in the activation of p47(phox) and production of reactive oxygen species involved in hyperoxia-mediated lung injury.

5. Spns2 plays key roles in regulating the cellular functions in non-small cell lung cancer (NSCLC) cells

6. mammals. These findings indicate that Spns2 is required for normal maintenance of the endocochlear potential and hence for normal auditory function, and support a role for S1P signalling in hearing.

7. Spns2 is an S1P transporter in vivo that plays a role in regulation not only of blood S1P but also lymph node and lymph S1P levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization.

8. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.