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Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Additionally we are shipping Spire Homolog 2 (Drosophila) Antibodies (37) and and many more products for this protein.
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The authors determined crystal structures of MyoVa-globular tail domain bound either to the Spir-2 motif or to Rab11 and show that a Spir-2:MyoVa:Rab11 complex can form.
We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection.
Spire1 and Spire2 drive two critical steps of asymmetric oocyte division
Spir-2 is found to be expressed as a single mRNA in the developing nervous system and intestine. In adult mouse it is expressed in epithelial cells of the digestive tract, in neuronal cells of the nervous system, and in testical spermatocytes.
influences intracellular replication of Salmonella typhimurium
This DNA damage-induced nuclear actin assembly requires two biologically and physically linked nucleation factors: Formin-2 and Spire-1/Spire-2.
We therefore characterized co-expressed Spir-2 and Fmn-2 fluorescent protein fusions . The data corroborate a model according to which Spir-2 exists in two different states, a cytosolic monomeric conformation and a membrane-bound state
both mammalian Spir proteins, Spir-1 and Spir-2, interact with mammalian Fmn subgroup proteins formin-1 and formin-2
Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in vesicle transport processes providing a novel link between actin organization and intracellular transport (By similarity).
protein spire homolog 2
, spire actin nucleation factor 2
, spire family actin nucleation factor 2
, spire homolog 2