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The protein encoded by SOAT1 belongs to the acyltransferase family. Additionally we are shipping SOAT1 Antibodies (25) and SOAT1 Kits (1) and many more products for this protein.
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Soat-1 role in atherosclerosis
Several residues in one subunit closely interact with the same residues in the other subunit; mutating these res. to Cys (show DNAJC5 Proteins) does not lead to loss in enzyme activity. Mutating residues F453, A457, or H460 to Cys (show DNAJC5 Proteins) causes large loss in enzyme activity.
increase in the in vitro ACAT1 (show ACAT1 Proteins) activity in PC-3 (show PCSK1 Proteins) prostate cancer cells treated with androgen
The results suggest that rs1044925 polymorphism in ACAT1 (show ACAT1 Proteins) gene is not only associated with serum LDL-C and nHDLC levels in healthy Chinese subjects in Chengdu area, but also with HDL (show HSD11B1 Proteins)-C level in subjects with endogenous hypertriglyceridemia.
RNA secondary structures located in the vicinity of the GGC (show GGCT Proteins)(1274-1276) codon are required for production of the 56-kDa isoform.
ACAT inhibition may stimulate cholesterol-catabolic (cytochrome P450) pathway in lesion-macrophages.
Angiotensin II enhances foam cell formation by upregulating ACAT1 (show ACAT1 Proteins) expression predominantly through the actions of AT(1) receptor via the G protein/c-Src (show SRC Proteins)/PKC (show PRRT2 Proteins)/MAPK (show MAPK1 Proteins) pathway in human monocyte-macrophages
Docosahexaenoic acid can act as a substrate for ACAT1 (show ACAT1 Proteins). In the manner of a poor substrate, docosahexaenoic acid also inhibited the activity of ACAT1 (show ACAT1 Proteins).
Results suggest that the ERK (show EPHB2 Proteins), p38MAPK (show MAPK14 Proteins) and JNK (show MAPK8 Proteins) signaling pathways may be involved in insulin (show INS Proteins)-mediated regulation of ACAT1 (show ACAT1 Proteins), but no PI3K (show PIK3CA Proteins) and PLC (show HSPG2 Proteins)-gamma signaling pathways were involved in the present study.
Leptin (show LEP Proteins) accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 (show ACAT1 Proteins) expression.
SOAT1 plays an important role in hypothalamic insulin (show INS Proteins) sensitivity, linked to cognitive impairment, in high fat diet-fed mice.
a potential regulatory relationship between the sterol O-acetyltransferase 1 gene and Hoxc13 gene
Soat1 is a quantitative trait loci gene contributing to hyperlipidemia.
soat1 had an important role in normal hair formation
ACAT1 activity plays a central role in the proper trafficking of cholesterol and in cholesterol-sensing in the macrophage.
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene.
sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
, sterol O-acyltransferase 1
, sterol O-acyltransferase 1-like
, sterol O-acyltransferase
, acyl-coenzyme A:cholesterol acyltransferase 1
, acyl coenzyme A:cholesterol acyltransferase 1
, adrenocortical lipid depletion
, cholesterol acyltransferase 1
, acyltransferase wax synthase
, Acyl-coenzyme A:cholesterol acyltransferase 1
, Cholesterol acyltransferase 1