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The protein encoded by STOX1 may function as a DNA binding protein.
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The STOX1 mice could help to better understand the endothelial dysfunction in the context of preeclampsia, and guide the search for efficient therapies able to protect the maternal endothelium during the disease and its aftermath.
Transcription factor STOX1A and its target gene, CNTNAP2 (show CNTNAP2 ELISA Kits), are potentially involved in the etiology of Alzheimer's disease.
STOX1 is one of the genes that give susceptibility for preeclampsia.
Mitotic entry is enhanced through the direct upregulation of cyclin B1 (show CCNB1 ELISA Kits) expression effectuated by STOX1A.
Upregulation of total tau expression (SFRS7 (show SFRS7 ELISA Kits)-independent) and tau exon 10 splicing (SFRS7 (show SFRS7 ELISA Kits)-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration.
STOX1 does not show differential expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR (show FGR ELISA Kits) as compared with controls.
methylation is independent of parental origin, but regulates STOX1 expression with the Y153H genotype directing the level of methylation.
The risk allele (Y153H) of the preeclampsia susceptibility gene STOX1 negatively regulates trophoblast invasion by upregulation of the cell-cell adhesion protein a-T-catenin (CTNNA3).
The data of this study indicated that STOX1 controls a conserved pathway shared between placenta and brain with overexpression in late-onset Alzheimer's disease.
In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene.
This study illustrates a SHH (show SHH ELISA Kits)-Stox1-Math1 (show ATOH1 ELISA Kits) regulatory axis in normal cerebellar development and medulloblastoma formation.
STOX1 is a novel stimulatory factor for inner ear epithelial cell proliferation and might be an important target to be considered in regeneration or repair of inner ear epithelium.
Our data posit STOX1 as a genetic switch in the ROS (show ROS1 ELISA Kits)/RNS (show FAM20C ELISA Kits) balance and suggest an explanation for elevated blood pressure in pre-eclampsia.
The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
storkhead box 1
, storkhead-box protein 1-like
, storkhead-box protein 1
, winged-helix domain-containing protein