Stress-Induced-phosphoprotein 1 Proteins (STIP1)

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A\; MIM 140550) and HSP90 (see HSP90AA1\; MIM 140571) in protein folding. Additionally we are shipping Stress-Induced-phosphoprotein 1 Antibodies (135) and Stress-Induced-phosphoprotein 1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STIP1 10963 P31948
STIP1 20867 Q60864
STIP1 192277 O35814
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Top Stress-Induced-phosphoprotein 1 Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Log in to see 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Insect cells (Sf9) Human His tag Validation with Western Blot 20 μg Log in to see Available
$504.90
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 13 to 16 Days
$400.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,551.17
Details
Escherichia coli (E. coli) Human GST tag,His tag 100 μg Log in to see 15 to 18 Days
$714.00
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$5,723.08
Details

STIP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , , ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Stress-Induced-phosphoprotein 1 (STIP1) Interaction Partners

Human Stress-Induced-phosphoprotein 1 (STIP1) interaction partners

  1. The G/G allele of stress induced phosphoprotein 1(STIP1) single nucleotide polymorphism rs4980524 is associated with the increased expression of STIP1 in endometriosis

  2. Significant genetic association was identified at the rs2236647 (T/C) SNP in STIP1 and risk of asthma (p < 0.001). The C allele and CC genotype of this SNP were significantly higher in asthmatics compared with controls.

  3. Functional studies showed that STIP1 promoted the growth, colony formation and migration of cancer cells. However, knocking down the expression of STIP1 inhibited the growth, colony formation and migration of cancer cells.

  4. In vitro experiments revealed that STIP1 was capable of binding to the MMP-9 (show MMP9 Proteins) promoter and enhanced its transcriptional expression

  5. STIP1 modulates the function of the HSP90 (show HSP90 Proteins)-JAK2 (show JAK2 Proteins)-STAT3 (show STAT3 Proteins) complex

  6. Hsp70/Hsp90-organizing protein promoter activity was highest in Hs578T which expressed mutant or inactive p53 (show TP53 Proteins). HRAS (show HRAS Proteins) activation of the Hsp70/Hsp90-organizing protein promoter was inhibited by p53 (show TP53 Proteins) overexpression.

  7. the modulation of HOP-PrP(C (show PRNP Proteins)) engagement or the decrease of PrP(C (show PRNP Proteins)) and HOP expression may represent a potential therapeutic intervention in glioblastoma.

  8. In conclusion, STIP1 is upregulated in HCC (show FAM126A Proteins) and associated with poor clinical prognosis. Blocking STIP1 activity suppresses HCC (show FAM126A Proteins) cell growth, providing the rationale for STIP1 as a potential therapeutic target in HCC (show FAM126A Proteins).

  9. Data suggest that calcium signaling plays important role in prevention of protein misfolding; complexes of S100A1 (show S100A1 Proteins) and STIP1 are key players in this pathway; the stoichiometry of S100A1 (show S100A1 Proteins)/STIP1 interaction appears to be three S100A1 (show S100A1 Proteins) dimers plus one STIP1 monomer; each S100A1 (show S100A1 Proteins)-STIP1-binding interaction is entropically driven. (S100A1 (show S100A1 Proteins) = S100 calcium binding protein A1 (show S100A1 Proteins); STIP1 = stress-induced-phosphoprotein 1) [REVIEW]

  10. Results indicte the great potential of STIP1 (stress-induced phosphoprotein 1) as a biomarker and therapeutic target in renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) bone metastasis.

Mouse (Murine) Stress-Induced-phosphoprotein 1 (STIP1) interaction partners

  1. In conclusion, STIP1 is upregulated in HCC (show FAM126A Proteins) and associated with poor clinical prognosis. Blocking STIP1 activity suppresses HCC (show FAM126A Proteins) cell growth, providing the rationale for STIP1 as a potential therapeutic target in HCC (show FAM126A Proteins).

  2. Domains of STIP1 responsible for regulating PrPC (show PRNP Proteins)-dependent amyloid-beta oligomer toxicity

  3. Reduced STIP1 levels can contribute to phenotypes related to hyperactivity and attention deficits.

  4. We correlate the expression of STI1 and glioma progression, and suggest that STI1 expression in microglia/macrophages and infiltrating lymphocytes is modulated by the brain tumor microenvironment.

  5. Knockdown of PIAS1 (show PIAS1 Proteins) in astrocytes impairs the accumulation of nuclear STI1 in response to irradiation. Moreover, a PIAS1 (show PIAS1 Proteins) mutant lacking the STI1 binding site is unable to increase STI1 nuclear retention.

  6. stress-inducible protein-1 has a role in recruitment of bone marrow derived cells into the ischemic brains

  7. Our findings reveal a previously unrecognized role of the PrP(C (show PRNP Proteins)) ligand STI1 in protecting neurons in Alzheimer disease and suggest a novel pathway that may help to offset AbetaO-induced toxicity.

  8. Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein (show PRNP Proteins).

  9. STI1 and laminin-gamma1 promote robust axonogenesis in wild-type dorsal root ganglia neurons; STI1 promotes extracellular calcium influx.

  10. Neuroprotection and neuritogenesis mediated by PrP(C (show PRNP Proteins))-STI1 engagement are dependent upon the increased protein synthesis mediated by PI3K-mTOR (show FRAP1 Proteins) signaling.

Stress-Induced-phosphoprotein 1 (STIP1) Protein Profile

Protein Summary

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A\; MIM 140550) and HSP90 (see HSP90AA1\; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005

Gene names and symbols associated with STIP1

  • stress induced phosphoprotein 1 (STIP1)
  • stress-induced phosphoprotein 1 (Stip1)
  • stress induced phosphoprotein 1 L homeolog (stip1.L)
  • Stress-induced-phosphoprotein 1 (GL50803_27310)
  • stress-induced-phosphoprotein 1 (PGTG_06468)
  • stress induced phosphoprotein 1 (stip1)
  • stress induced phosphoprotein 1 S homeolog (stip1.S)
  • stress-induced phosphoprotein 1 (stip1)
  • stress induced phosphoprotein 1 (Stip1)
  • Hop protein
  • IEF-SSP-3521 protein
  • MGC53256 protein
  • MGC76181 protein
  • MGC82554 protein
  • p60 protein
  • Sti1 protein
  • STI1L protein
  • stip1 protein
  • zgc:92133 protein

Protein level used designations for STIP1

Hsp70/Hsp90-organizing protein , NY-REN-11 antigen , hsc70/Hsp90-organizing protein , renal carcinoma antigen NY-REN-11 , transformation-sensitive protein IEF SSP 3521 , Hsp70/Hsp90 organizing protein , IEF SSP 3521 , mSTI1 , stress-induced-phosphoprotein 1 , stress-inducible protein , STI1 , hop , stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) , Stress-induced-phosphoprotein 1 , Hsc70/Hsp90-organizing protein

GENE ID SPECIES
10963 Homo sapiens
20867 Mus musculus
192277 Rattus norvegicus
379955 Xenopus laevis
451286 Pan troglodytes
474837 Canis lupus familiaris
717926 Macaca mulatta
5697231 Giardia lamblia ATCC 50803
10539523 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100356266 Oryctolagus cuniculus
394990 Xenopus (Silurana) tropicalis
447010 Xenopus laevis
493606 Danio rerio
617109 Bos taurus
100689413 Cricetulus griseus
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