Stress-Induced-phosphoprotein 1 Proteins (STIP1)

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A\; MIM 140550) and HSP90 (see HSP90AA1\; MIM 140571) in protein folding. Additionally we are shipping Stress-Induced-phosphoprotein 1 Antibodies (131) and Stress-Induced-phosphoprotein 1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STIP1 10963 P31948
STIP1 20867 Q60864
STIP1 192277 O35814
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Top Stress-Induced-phosphoprotein 1 Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Log in to see 11 Days
$411.40
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$504.90
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 13 to 16 Days
$400.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,551.17
Details
Escherichia coli (E. coli) Human GST tag,His tag 100 μg Log in to see 15 to 18 Days
$714.00
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$6,867.69
Details

STIP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , , ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Stress-Induced-phosphoprotein 1 (STIP1) Interaction Partners

Human Stress-Induced-phosphoprotein 1 (STIP1) interaction partners

  1. The G/G allele of stress induced phosphoprotein 1(STIP1) single nucleotide polymorphism rs4980524 is associated with the increased expression of STIP1 in endometriosis

  2. Significant genetic association was identified at the rs2236647 (T/C) SNP in STIP1 and risk of asthma (p < 0.001). The C allele and CC genotype of this SNP were significantly higher in asthmatics compared with controls.

  3. Functional studies showed that STIP1 promoted the growth, colony formation and migration of cancer cells. However, knocking down the expression of STIP1 inhibited the growth, colony formation and migration of cancer cells.

  4. In vitro experiments revealed that STIP1 was capable of binding to the MMP-9 promoter and enhanced its transcriptional expression

  5. STIP1 modulates the function of the HSP90-JAK2-STAT3 complex

  6. Hsp70/Hsp90-organizing protein promoter activity was highest in Hs578T which expressed mutant or inactive p53. HRAS activation of the Hsp70/Hsp90-organizing protein promoter was inhibited by p53 overexpression.

  7. the modulation of HOP-PrP(C) engagement or the decrease of PrP(C) and HOP expression may represent a potential therapeutic intervention in glioblastoma.

  8. In conclusion, STIP1 is upregulated in HCC and associated with poor clinical prognosis. Blocking STIP1 activity suppresses HCC cell growth, providing the rationale for STIP1 as a potential therapeutic target in HCC.

  9. Data suggest that calcium signaling plays important role in prevention of protein misfolding; complexes of S100A1 and STIP1 are key players in this pathway; the stoichiometry of S100A1/STIP1 interaction appears to be three S100A1 dimers plus one STIP1 monomer; each S100A1-STIP1-binding interaction is entropically driven. (S100A1 = S100 calcium binding protein A1; STIP1 = stress-induced-phosphoprotein 1) [REVIEW]

  10. Results indicte the great potential of STIP1 (stress-induced phosphoprotein 1) as a biomarker and therapeutic target in renal cell carcinoma (RCC) bone metastasis.

  11. Data suggest that three dimers of S100A1 (S100 calcium binding protein A1) associate with one molecule of STIP1 (stress-inducible phosphoprotein 1) in a calcium-dependent manner; individual STIP1 TPR (tetratricopeptide repeat) domains, TPR1, TPR2A and TPR2B, bind a single S100A1 dimer with significantly different affinities; TPR2B domain possesses highest affinity for S100A1.

  12. Data confirmed the significant up-regulation of STIP1 in tumorous cholangiocytes relative to normal hepatocytes and non-tumorous cells and show prooved it as a reliable diagnostic biomarker when using immunohistochemistry.

  13. STIP1 and moesin may be novel and differential sero-diagnostic markers for psoriasis vulgaris and psoriatic arthritis

  14. Stip1 has a role in the male reproductive system and is expressed during the stress response

  15. Increased STIP1 expression is associated with poor survival outcome in epithelial ovarian cancer (EOC), and STIP1 may represent a useful therapeutic target in EOC patients.

  16. our findings provide evidences that positive expression of STIP1 in papillary thyroid carcinoma may be important in the acquisition of an aggressive phenotype

  17. These results indicate that HOP is a unique co-chaperone that undergoes an ATP-dependent conformational change.

  18. STIP1 histoscores may be useful in detecting invasive human ovarian cancer in patients with low serum CA125 levels.

  19. stress-inducible protein-1 has a role in recruitment of bone marrow derived cells into the ischemic brains

  20. results show phosphorylation of the C-terminal region of Hsp70 and Hsp90 is critical for the decision between folding or degradation of client proteins by altering the binding of CHIP and HOP; also show increased phosphorylation in cancer cells with increased levels of the co-chaperone HOP

Mouse (Murine) Stress-Induced-phosphoprotein 1 (STIP1) interaction partners

  1. In conclusion, STIP1 is upregulated in HCC and associated with poor clinical prognosis. Blocking STIP1 activity suppresses HCC cell growth, providing the rationale for STIP1 as a potential therapeutic target in HCC.

  2. Domains of STIP1 responsible for regulating PrPC-dependent amyloid-beta oligomer toxicity

  3. Reduced STIP1 levels can contribute to phenotypes related to hyperactivity and attention deficits.

  4. We correlate the expression of STI1 and glioma progression, and suggest that STI1 expression in microglia/macrophages and infiltrating lymphocytes is modulated by the brain tumor microenvironment.

  5. Knockdown of PIAS1 in astrocytes impairs the accumulation of nuclear STI1 in response to irradiation. Moreover, a PIAS1 mutant lacking the STI1 binding site is unable to increase STI1 nuclear retention.

  6. stress-inducible protein-1 has a role in recruitment of bone marrow derived cells into the ischemic brains

  7. Our findings reveal a previously unrecognized role of the PrP(C) ligand STI1 in protecting neurons in Alzheimer disease and suggest a novel pathway that may help to offset AbetaO-induced toxicity.

  8. Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein.

  9. STI1 and laminin-gamma1 promote robust axonogenesis in wild-type dorsal root ganglia neurons; STI1 promotes extracellular calcium influx.

  10. Neuroprotection and neuritogenesis mediated by PrP(C)-STI1 engagement are dependent upon the increased protein synthesis mediated by PI3K-mTOR signaling.

  11. evaluated the temporal expression pattern of STI1 and Vn and their colocalization with their ligand PrPC, demonstrated that PrPC, STI1, and Vn are coexpressed in most of the embryonic tissues evaluated.

  12. Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. The interaction sites were mapped to amino acids 113-128 from PrP(c) and 230-245 from STI1. Both proteins are associated in vivo.

  13. mSTI1 has a specific tetratricopeptide repeat motif that enables it to bind to HSC70

  14. first evidence of nuclear import and export of major Hsp70/Hsp90 co-chaperone mSTI1, and the regulation of this nuclear-cytoplasmic shuttling by cell cycle status and cell cycle kinases

  15. These data are consistent with results established with a model where OR and N-terminal half of the HR mediate the action of STI1 upon cell survival and upregulation of SOD activity.

  16. Stress-inducible protein 1 added to hippocampal cultures interacts with cellular prion protein (PrPc) and elicits neuritogenesis in wild-type neurons, but not PrPc-null cells.

  17. This suggests an important role for Stip1 in the ability of germ cells to survive in stress conditions including high temperatures.

  18. Hop may be cleaved by GzmB as an "innocent bystander" during the induction of apoptosis, but it may also act to facilitate apoptosis in concert with other GzmB substrates

  19. Hop/STI1 can modulate both proliferation and cell death in the developing retina independent of PrP(C).

  20. These results show that PrP(C) endocytosis is a necessary step to modulate STI1-dependent ERK1/2 signaling involved in neuritogenesis.

Stress-Induced-phosphoprotein 1 (STIP1) Protein Profile

Protein Summary

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A\; MIM 140550) and HSP90 (see HSP90AA1\; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005

Gene names and symbols associated with STIP1

  • stress induced phosphoprotein 1 (STIP1)
  • stress-induced phosphoprotein 1 (Stip1)
  • stress induced phosphoprotein 1 L homeolog (stip1.L)
  • Stress-induced-phosphoprotein 1 (GL50803_27310)
  • stress-induced-phosphoprotein 1 (PGTG_06468)
  • stress induced phosphoprotein 1 (stip1)
  • stress induced phosphoprotein 1 S homeolog (stip1.S)
  • stress-induced phosphoprotein 1 (stip1)
  • stress induced phosphoprotein 1 (Stip1)
  • Hop protein
  • IEF-SSP-3521 protein
  • MGC53256 protein
  • MGC76181 protein
  • MGC82554 protein
  • p60 protein
  • Sti1 protein
  • STI1L protein
  • stip1 protein
  • zgc:92133 protein

Protein level used designations for STIP1

Hsp70/Hsp90-organizing protein , NY-REN-11 antigen , hsc70/Hsp90-organizing protein , renal carcinoma antigen NY-REN-11 , transformation-sensitive protein IEF SSP 3521 , Hsp70/Hsp90 organizing protein , IEF SSP 3521 , mSTI1 , stress-induced-phosphoprotein 1 , stress-inducible protein , STI1 , hop , stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) , Stress-induced-phosphoprotein 1 , Hsc70/Hsp90-organizing protein

GENE ID SPECIES
10963 Homo sapiens
20867 Mus musculus
192277 Rattus norvegicus
379955 Xenopus laevis
451286 Pan troglodytes
474837 Canis lupus familiaris
717926 Macaca mulatta
5697231 Giardia lamblia ATCC 50803
10539523 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100356266 Oryctolagus cuniculus
394990 Xenopus (Silurana) tropicalis
447010 Xenopus laevis
493606 Danio rerio
617109 Bos taurus
100689413 Cricetulus griseus
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