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Meiosis specific component of cohesin complex. Additionally we are shipping and many more products for this protein.
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Human Polyclonal STAG3 Primary Antibody for ELISA - ABIN451624
Storre, Schäfer, Reichert, Barbero, Hauser, Eilers, Gaubatz: Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells by E2F6. in The Journal of biological chemistry 2005
Our genetic analysis demonstrates that cohesins containing STAG3 and REC8 are the main complex required for centromeric cohesion, and RAD21L cohesins are required for normal clustering of pericentromeric heterochromatin. Furthermore, the STAG3/REC8 and STAG3/RAD21L cohesins are the primary cohesins required for axis formation.
our data suggests that STAG3 is required for structural changes of chromosomes that mediate chromosome pairing and synapsis, DNA repair and progression of meiosis.
STAG3 is a strong candidate gene for male infertility
STAG3 emerges as the key STAG cohesin involved in major functions of meiotic cohesin.
STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions.
E2F6 (show E2F6 Antibodies) silences SMC1beta (show SMC1B Antibodies) and STAG3 in somatic cells
Loss of STAG2 (show STAG2 Antibodies) or STAG3, which encode subunits of the cohesin complex (show SMC3 Antibodies), in melanoma cells results in resistance to BRAF (show BRAF Antibodies) inhibitors (BRAFi). Loss-of-function mutations in STAG2 (show STAG2 Antibodies), as well as decreased expression of STAG2 (show STAG2 Antibodies) or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines.
STAG3 truncating variant as the cause of primary ovarian insufficiency has been found in two sisters in a consanguineous Lebanese family.
We identified a homozygous 1-bp deletion inducing a frameshift mutation in STAG3 on chromosome 7. Female mice devoid of Stag3 are sterile.
we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer
Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
cohesin subunit SA-3
, stromal antigen 3
, cohesin subunit SA-3-like
, SCC3 homolog 3
, stromalin 3