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Meiosis specific component of cohesin complex. Additionally we are shipping and many more products for this protein.
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Human Polyclonal STAG3 Primary Antibody for ELISA - ABIN547926
Storre, Schäfer, Reichert, Barbero, Hauser, Eilers, Gaubatz: Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells by E2F6. in The Journal of biological chemistry 2005
c.677C > G associated with primary ovarian insufficiency
Loss of STAG2 or STAG3, which encode subunits of the cohesin complex, in melanoma cells results in resistance to BRAF inhibitors (BRAFi). Loss-of-function mutations in STAG2, as well as decreased expression of STAG2 or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines.
STAG3 truncating variant as the cause of primary ovarian insufficiency has been found in two sisters in a consanguineous Lebanese family.
We identified a homozygous 1-bp deletion inducing a frameshift mutation in STAG3 on chromosome 7. Female mice devoid of Stag3 are sterile.
we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer
identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells
plays a role in regulation of transcription due to genetic imprinting, sister chromatid exchange, chromosome segregation and as an insulator element. (review)
Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
cohesin subunit SA-3
, stromal antigen 3
, cohesin subunit SA-3-like
, SCC3 homolog 3
, stromalin 3