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The protein encoded by SDF2 is believed to be a secretory protein. Additionally we are shipping SDF2 Antibodies (49) and SDF2 Kits (17) and many more products for this protein.
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Comparing the amino acid sequence and predicted 3D structure with other Sdf2-like proteins we suggest a role of mouse Sdf2 in the Unfolded Protein Response and ER-stress, similar to that of Sdf2l1 from human and mouse and SDF2-like from Arabidopsis
SDF2 associates with ERdj3 (show DNAJB11 Proteins) and acts as a component in the BiP (show GDF10 Proteins) chaperone cycle to prevent the aggregation of misfolded proteins.
These findings suggest that SDF2 may be an important regulatory factor by which trophoblast cells can control cell survival under ER stress.
Hsp72 (show HSPA1A Proteins) prevented SDF-2 degradation in a chaperone activity-dependent manner avoiding oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells.
Data indicate a function for stromal cell-derived factor 2 (SDF2) as a component of the heat-shock proteins 90-endothelial nitric oxide synthase (show NOS3 Proteins) (Hsp90 (show HSP90 Proteins)-eNOS (show NOS3 Proteins)) complex that is critical for signal transduction in endothelial cells.
SDF-2, SDF-4 (show SDF4 Proteins) and SDF-5 (show SFRP2 Proteins) are expressed in mammary tissues and cells and that a reduced level of SDF-2 and SDF-4 (show SDF4 Proteins) are associated with a poor clinical outcome.
The protein encoded by this gene is believed to be a secretory protein. It has regions of similarity to hydrophilic segments of yeast mannosyltransferases. Its expression is ubiquitous and the gene appears to be relatively conserved among mammals. Alternate splicing results in both coding and non-coding variants. A pseudogene of this gene is located on chromosome 15.
stromal cell-derived factor 2
, stromal cell derived factor 2