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SUCNR1 encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. Additionally we are shipping Succinate Receptor 1 Kits (4) and Succinate Receptor 1 Proteins (3) and many more products for this protein.
Showing 10 out of 63 products:
Human Polyclonal SUCNR1 Primary Antibody for ICC, IF - ABIN314630
Hu, Wu, Li, Chen, Wang: Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91. in Experimental eye research 2013
Show all 7 Pubmed References
Human Polyclonal SUCNR1 Primary Antibody for IHC (p) - ABIN4356702
McCreath, Espada, Gálvez, Benito, de Molina, Sepúlveda, Cervera: Targeted disruption of the SUCNR1 metabolic receptor leads to dichotomous effects on obesity. in Diabetes 2015
activation of SUCNR1 in macrophages is important for both infiltration and inflammation of adipose tissue in obesity
This study shows that metformin can attenuate activation of HSCs by activating the AMPK (show PRKAA1 Antibodies) pathway and inhibiting the succinate-GPR91 pathway. Metformin has therapeutic potential for treating steatohepatitis and liver fibrosis.
This study reports the expression of GPR91 on mouse and human mast cells and reveals a hyperactive behavior of mouse Sucnr1-/- mast cells in a mechanistic in vivo model of skin inflammation.
Data show that succinate upregulates vascular endothelial growth factor (VEGF (show VEGF Antibodies)) expression by activation of signal transducer and activator of transcription 3 (STAT3 (show STAT3 Antibodies)) and extracellular regulated kinase (ERK)1 (show MAPK3 Antibodies)/2 via its receptor G-protein coupled receptor 91 (GPR91).
Succinate is abundant in synovial fluids from rheumatoid arthritis (RA) patients, and these fluids elicit IL-1beta (show IL1B Antibodies) release from macrophages in a GPR91-dependent manner.
We give an exhaustive overview of the known and hypothetical signaling partners of SUCNR1 in different in vitro and in vivo systems and also discuss the link between SUCNR1 intracellular pathways and its pathophysiological roles.
Through GPR91, succinate is involved in functions such as regulation of blood pressure, inhibition of lipolysis in white adipose tissue, development of retinal vascularization and cardiac hypertrophy. [review]
The findings indicate that succinate-GPR91 signaling may be involved in right ventricular hypertrophy via PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling in vivo and in vitro.
results show that succinate plays an important role in HSC (show FUT1 Antibodies) activation through GPR91 induction, and suggest that succinate and GPR91 may represent new therapeutic targets for modulating hepatic fibrosis
These results show for the first time that succinate plays an important role in cardiomyocyte hypertrophy through GPR91 activation and extend our understanding of how ischemia can induce hypertrophic cardiomyopathy
Sucnr1 knockout mice had increased energy expenditure, less white adipose tissue, and improved glucose buffering compared with controls. They became progressively hyperglycemic and failed to secrete insulin (show INS Antibodies). Sucrn1 may be a sensor for dietary energy.
These findings suggest that deficiency in SUCNR1 is a possible contributing factor to the pathogenesis of dry age-related macular degeneration.
GPR91 is expressed in the retinal pigment epithelium with specific localization to the apical membrane, indicating that succinate in the subretinal space serves as the GPR91 agonist
SUCNR1 is located in the luminal membrane of macula densa cells of the juxtaglomerular apparatus in close proximity to renin (show REN Antibodies)-producing granular cells, the cortical thick ascending limb, and cortical and inner medullary collecting duct cells.
GPR91, a previously orphan G-protein-coupled receptor (show GPRC5C Antibodies), functions as a receptor for the citric acid cycle intermediate succinate
Release of the prohypertensive hormone renin (show REN Antibodies) by the kidney, triggered by high levels of glucose, is mediated by a succinate / GPR91 paracrine signaling cascade in the glomerular endothelium.
Macul densa cells can sense alterations in local tissue metabolism via accumulation of tubular succinate and GPR91 signaling.
This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis.
G protein-coupled receptor 91
, G-protein coupled receptor 91
, P2Y purinoceptor 1
, probable G-protein coupled receptor 19
, G protein-coupled receptor 19
, probable G-protein coupled receptor 19-like
, succinate receptor 1
, G-protein-coupled receptor 91