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SI encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border.
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Human Polyclonal SI Primary Antibody for IHC, IHC (p) - ABIN4353435
Krishnan, Lapierre, Knowles, Goldenring: Rab25 regulates integrin expression in polarized colonic epithelial cells. in Molecular biology of the cell 2013
Core2 O-glycan structure is essential for expression of SI and DDP (show TIMM8A Antibodies)-IV during intestinal cell differentiation.
These suggest that induction of SI gene by the diet rich in carbohydrate is associated with acetylation of histone H3 (show HIST3H3 Antibodies) and H4 as well as binding of HNF-1 (show HNF1A Antibodies) and Cdx-2 (show CDX2 Antibodies) on SI gene.
These results suggest that sucrase-isomaltase transcription might be unchanged or lower in maturity-onset diabetes of the young (MODY (show HNF4A Antibodies)) type 3, but greater in MODY5 (show HNF1B Antibodies).
phenylalanine cluster is required for shielding a folding determinant in the extracellular domain of SI; substitution of a Q by a P at residue 1098 of sucrase disrupts this determinant and elicits retention of SI(Q1098P) in ER and cis (show CISH Antibodies)-Golgi
hepatocyte nuclear factor (HNF)-1alpha (show HNF1A Antibodies) and HNF-1beta (show HNF1B Antibodies) would contribute to constitutive expression of the SI gene in the differentiated state in Caco-2 cells
glucose regulation of sucrase-isomaltase gene expression was attenuated in HNF-1alphaT539fsdelC cells, but was well maintained in empty vector & HNF-1betaR177X cells.Results suggest that HNF-1alpha (show HNF1A Antibodies) participates in glucose regulation of SI gene expression.
This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.
, sucrase isomaltase, structural
, oligosaccharide alpha-1,6-glucosidase