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Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate.
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Human Polyclonal SUV39H2 Primary Antibody for IHC (p), WB - ABIN388081
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
Show all 4 Pubmed References
Rat (Rattus) Polyclonal SUV39H2 Primary Antibody for ChIP, ELISA - ABIN249721
Peters, OCarroll, Scherthan, Mechtler, Sauer, Schöfer, Weipoltshammer, Pagani, Lachner, Kohlmaier, Opravil, Doyle, Sibilia, Jenuwein: Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. in Cell 2001
Our finding unveils a novel autoregulatory mechanism of SUV39H2 through lysine automethylation
Our data show that the differential expression of SUV39H1 (show SUV39H1 Antibodies) and SUV39H2 is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution
SUV39H2 functioned cooperatively with MAGE-A11 to increase androgen-dependent AR transcriptional activity.
histone H3 (show HIST3H3 Antibodies) lysine 9 methylation reduction, which may be due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase (show MBD2 Antibodies) KDM4C (show KDM4C Antibodies), was found in CD4 (show CD4 Antibodies)(+) T lymphocytes of Latent autoimmune diabetes in adults patients
data cannot finally exclude H2AX (show H2AFX Antibodies) methylation of SUV39H2 in cells, additional experimental evidence is required to validate this claim.
Our results reveal the regulatory mechanism of LSD1 (show KDM1A Antibodies) protein through its lysine methylation by SUV39H2 in human cancer cells
We also demonstrate that the N324K mutant in the SET domain of SUV39H2 that has been shown to cause an inherited nasal skin disease in Labrador Retrievers renders SUV39H2 inactive
Expression of JHDM2A (show KDM3A Antibodies) was significantly increased but HDAC2 (show HDAC2 Antibodies), HDAC7 (show HDAC7 Antibodies), and SUV39H2 were significantly down-regulated in Systemic Sclerosis B cells relative to controls
genetic association studies in a Finnish population with type I diabetes: The minor T allele of exonic SNP rs17353856 in SUV39H2 is associated with diabetic retinopathy (in a larger meta-analysis); thus an genetic variation may be protective.
findings suggest that Suv39H1 (show SUV39H1 Antibodies) and Suv39H2 are key hypoxia-induced methyltransferases; their decline in fetal lung during late gestation is critical for epigenetic changes resulting in the developmental induction of SP-A
The authors show here that the mouse Suv39h2 enzyme differs from Suv39h1 (show SUV39H1 Antibodies) by containing an N-terminal basic domain that facilitates retention at mitotic chromatin and provides an additional affinity for major satellite repeat RNA.
Data indicate that histone methyltransferase Suv39h2 expression is up-regulated in the liver in liver steatosis.
Repeat-associated, Suv39h (show SUV39H1 Antibodies)-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.
ESET (show SETDB1 Antibodies) histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1 (show HDAC1 Antibodies)/2 that participates in multiple pathways of transcriptional repression.
Taken together, the results indicate epigenetic regulation of telomere length in mammals by Suv39h1 (show SUV39H1 Antibodies) and Suv39h2.
Knockdown of SUV39H1 (show SUV39H1 Antibodies) and SUV39H2 in embryonic stem-like cells and embryonic fibroblasts increases telomere length.
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).
, histone H3-K9 methyltransferase 2
, histone-lysine N-methyltransferase SUV39H2
, lysine N-methyltransferase 1B
, su(var)3-9 homolog 2
, Suv39h histone methyltransferase
, suppressor of variegation 3-9 homolog 2 (Drosophila)
, histone-lysine N-methyltransferase SUV39H2-like