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May play a role in the cell attachment process..
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Downregulation of SVEP1 expression in primary keratinocytes resulted in decreased expression of major epidermal differentiation markers.
Top association findings suggested that the bipolar disorder risk allele at SNP rs7042161 in SVEP1 gene may be associated with increased risk of essential hypertension.
We also found significant associations between coronary artery disease and low-frequency missense variants in the genes SVEP1.
polydom is a hitherto unknown ligand for integrin alpha9beta1 that functions as a physiological ligand in vivo.
Increased UT-II, sTM, and vWF (show VWF Antibodies) in ankylosing spondylitis patient sera regardless of treatment and disease activity suggest an increased tendency for atherosclerosis.
acts as regulator of ICAM1 (show ICAM1 Antibodies) and E-selectin (show SELE Antibodies) during endotoxemia
All together makes SEL-OB/SVEP1 an attractive marker for studying the role of stromal osteogenic cells and their interactions within the bone marrow microenvironment creating a network that regulates the skeletal homeostasis.
Polydom deposited around lymphatic vessels seems to ensure Foxc2 (show FOXC2 Antibodies) upregulation in lymphatic endothelial cells, possibly via the Ang-2 (show ANGPT2 Antibodies) and Tie1 (show TIE1 Antibodies)/Tie2 (show TEK Antibodies) receptor system, to regulate lymphangiogenesis.
Polydom/Svep1 is an essential extracellular factors for lymphangiogenesis.
Our results show that the putative promoter of SVEP1 is hypermethylated in DA3- compared with MBA-15 cells, thus regulating SVEP1 expression levels
May play a role in the cell attachment process.
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
, sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like
, CCP module-containing protein 22
, selectin-like osteoblast-derived protein
, selectin-like protein
, serologically defined breast cancer antigen NY-BR-38
, sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
, polydomain protein (Polydom)
, Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1