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Synovial sarcomas occur most frequently in the extremities around large joints. Additionally we are shipping SS18L1 Antibodies (35) and many more products for this protein.
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calcium-responsive transactivator and certain other amyotrophic lateral sclerosis-linked proteins share several features implicated in amyotrophic lateral sclerosis pathogenesis
This study demonistrated that CREST mutations inhibited activity-dependent neurite outgrowth in primary neurons, and CREST associated with the ALS (show IGFALS Proteins) protein FUS (show FUS Proteins).
A synovial sarcoma of classic morphology contained a novel t(20;X) SS18L1(strong homology to SS18 (show SS18 Proteins) on Ch20)/SSX1 (show SSX1 Proteins) fusion transcript in which nucleotide 1216 (exon 10) of SS18L1 was fused in-frame with nucleotide 422 (exon 6) of SSX1 (show SSX1 Proteins).
SS18 (show SS18 Proteins) and SS18L1 genes map within co-linear DNA segments that may have evolved through a relatively recent genomic duplication event.
Data suggest that co-activation of CREST and CBP (CREB-binding protein (show CREBBP Proteins)) enhances signaling between p-Creb (show CREB1 Proteins)/AP-1 (show JUN Proteins) and p-HIF-1 (show HIF1A Proteins)/HRE resulting in up-regulation of Glut3 (glucose transporter type 3 (show SLC2A3 Proteins)); here, stimulus was cell hypoxia.
Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X\;18)(p11.2\;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L1 gene is homologous to SS18.
synovial sarcoma translocation gene on chromosome 18-like 1
, SS18-like protein 1
, calcium-responsive transactivator
, ss18-like protein 1
, SYT homolog 1
, calcium-responsive transcription coactivator