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SNCG encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases.
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LncRNA-AK058003 can reduce the expression of mRNA stabilizing protein HuR and act as a precursor of miR-15a to suppress gamma-synuclein-mediated cell proliferation and the metastasis of hepatocellular carcinoma.
Results demonstrated that urine SNCG can discriminate bladder cancer from urinary diseases, and is a useful prognosticator of postsurgical recurrence.
A positive SNCG may serve as a potential marker to identify breast cancer patients who are less likely to benefit from radiotherapy
This largest collection of USCs to date demonstrates that SNCG was associated with poor survival in univariate analyses. SNCG does not predict survival outcome independent of p53 and p16 in models that jointly consider multiple markers.
SNCG expression in ovarian cancer is frequent in patients with high-risk features, but it does not correlate with chemotherapy response, overall survival, or progression-free survival.
High synoretin expression is associated with non-small cell lung cancer.
Study shows an overexpression of SNCG in bladder cancer (BC) tissues which correlates positively with neoplasm recurrence. SNCG seems a good marker to predict recurrence of BC, but not a reliable one for staging or prediction of survival rate.
down-regulation of gamma-synuclein reduces the protein level of PLCbeta but increases the transcript level over 40 fold
the conformational dynamics of ERalpha36 in the absence and presence of Hsp90 (show HSP90 Antibodies) and gammaSyn, is reported.
SNCG may promote MCF7 cell migration through activating the Erk (show EPHB2 Antibodies) pathway and breaking cell-cell junctions.
results indicate that gamma-synuclein is capable of binding to synaptic vesicles, but the mechanism of its interaction with these structures is fundamentally different from the mechanism proposed for alpha-synuclein
The results of this study suggested that gamma-synuclein is directly involved in the regulation of cognitive functions.
gamma-Synuclein binds synaptic vesicles but is unable to rescue the phenotype of CSPalpha-deficient mice.
gamma-synuclein is a regulator of lipid handling in adipocytes, the function of which is particularly important in conditions of nutrient excess
The loss of gamma-synuclein results in a significant increase in the level of orientation response in novel environment and decrease in the level of state anxiety.
gamma-Synuclein is necessary for the increased Mac-2 (show LGALS3 Antibodies) expression by myelination-transition-zone astrocytes during glaucoma.
The effects of gamma-synuclein deficiency on motor and peripheral sensory neurons were studied. Gamma-synuclein is dispensable for the development and function of the nervous system.
Immunohistochemistry demonstrates accelerated accumulation of gamma-synuclein in gracile axonal dystrophy mice. Gamma-synuclein appears in the gracile (show BCS1L Antibodies) nucleus at 3 weeks of age and was maintained until 32 weeks.
These data indicate the chaperone activity of SNCG on stimulation of steroid receptor (show ESR2 Antibodies) signaling in mammary gland.
Differences between alpha- and gamma-synuclein secondary structure propensities.
This work reports the cloning and characterization of the porcine (Sus scrofa) gamma-synuclein cDNA (SNCG).
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development.
breast cancer-specific gene 1 protein
, sensory neuron synuclein
, synuclein, gamma
, synuclein, gamma (breast cancer-specific protein 1)