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TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping T-Complex Protein 1 Kits (5) and T-Complex Protein 1 Proteins (4) and many more products for this protein.
Showing 10 out of 121 products:
Human Polyclonal TCP1 Primary Antibody for ChIP, ICC - ABIN2668832
Rhie, Hazelett, Coetzee, Yan, Noushmehr, Coetzee: Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells. in BMC genomics 2014
Show all 3 Pubmed References
Human Polyclonal TCP1 Primary Antibody for IF (p), IHC (p) - ABIN672336
Yang, Xie, Shu, Liu, Chen, Ruan, Qi: An improved method for the isolation and culture of rat epidermal stem cells. in International journal of clinical and experimental pathology 2013
Show all 2 Pubmed References
Human Polyclonal TCP1 Primary Antibody for IF (p) - ABIN909814
Quantius, Schmoldt, Vazquez-Armendariz, Becker, El Agha, Wilhelm, Morty, Vadász, Mayer, Gattenloehner, Fink, Matrosovich, Li, Seeger, Lohmeyer, Bellusci, Herold: Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. in PLoS pathogens 2016
treating BACHD cortical neurons with ApiCCT1 prevented BACHD striatal neuronal atrophy by enhancing release of BDNF (show BDNF Antibodies) that subsequently acts through tyrosine receptor kinase B (TrkB (show NTRK2 Antibodies)) receptor on striatal neurons. Our findings are evidence that TRiC (show MARVELD2 Antibodies) reagent-mediated reductions in mHTT enhanced BDNF (show BDNF Antibodies) delivery to restore the trophic status of BACHD striatal neurons.
this study shows that CCTalpha (show PCYT1A Antibodies) is required for antigen-specific, germinal center-derived memory B cells
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 Antibodies) (P2X7R (show P2RX7 Antibodies)) and plays a role in lymphoid neoplasm metastasis.
The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Antibodies) and actin mediated via gelsolin (show GSN Antibodies), suggesting that CCT (show FLVCR2 Antibodies) may influence processes depending on gelsolin (show GSN Antibodies) activity, such as cell motility.
Host CCTalpha (show PCYT1A Antibodies) is required for efficient transcription and replication of rabies virus.
Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia
Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.
Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.
TRiC (show MARVELD2 Antibodies)-peptide complexes of the heat shock protein 60 (show HSPD1 Antibodies) family are efficient vehicles of cross-presentation in assays in vitro and in mice in vivo; immunization with TRiC (show MARVELD2 Antibodies) purified from a tumor elicits specific protection against a challenge with that tumor.
downregulated expression in T cells following treatment with bis (show BAG3 Antibodies)(tri (show VANGL2 Antibodies)-n-butylin)oxide (TBTO), an immunotoxic organotin
the majority of cells within the tumor appears to express predominantly TAp63 isoform. While DeltaNp63 exerts its effects by regulating a PI3K (show PIK3CA Antibodies)/CD44v6 pathway.
These data suggest that TP63 (show TP63 Antibodies) is a novel Lacrimo-auriculo-dento-digital syndrome gene and may also influence corneal thickness and risk for open-angle glaucoma.
the strong repression of Np63 (show TP63 Antibodies) by H-RAS (show HRAS Antibodies) and PIK3CA (show PIK3CA Antibodies) and induction of EMT (show ITK Antibodies) suggest that this process is critical for mammary tumorigenesis.
This study suggests that in patients with CD30 (show TNFRSF8 Antibodies)+ lymphoproliferative disorders, an aggressive clinical course cannot be defined by the presence of TP63 (show TP63 Antibodies) rearrangements, as was recently shown in systemic ALK (show ALK Antibodies) negative anaplastic large cell lymphoma.
This study revealed the possible association between TP63 (show TP63 Antibodies) and Mullerian duct anomalies and suggested a potential contribution of microRNA-regulated expression of genes in the etiology of Mullerian duct anomalies.
We identified a list of thirty genes repressed by DeltaNp63 in a SETDB1 (show SETDB1 Antibodies)-dependent manner, whose expression is positively correlated to survival of breast cancer patients. These results suggest that p63 (show RPE65 Antibodies) and SETDB1 (show SETDB1 Antibodies) expression, together with the repressed genes, may have diagnostic and prognostic potential
Dysregulation of JAM-A (show F11R Antibodies) via p63 (show RPE65 Antibodies)/GATA-3 (show GATA3 Antibodies) signaling pathway occurs in squamous cell carcinomas of the head and neck.
This study investigated the expression of p40 (show IL9 Antibodies) protein in meningiomas and explored its usefulness as prognostic marker in addition to PgR (show PGR Antibodies) and Ki67 (show MKI67 Antibodies).
the transactivation inhibitory (TI) domains within the alpha-isoform-specific C termini of p63 (show RPE65 Antibodies) and p73 (show TP73 Antibodies) are essential for binding to p53R175H.
Data show that a two-marker panel of p40 (show IL9 Antibodies) (DeltaNp63) and CDX2 (show CDX2 Antibodies) is highly sensitive and specific.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, T-complex protein 1 subunit alpha
, T-complex protein 1 subunit alpha A
, T-complex protein 1 subunit alpha B
, t-complex polypeptide 1
, tailless complex polypeptide 1A
, tailless complex polypeptide 1B
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, transformation related protein 63
, tumor protein 63 kDa