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TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping T-Complex Protein 1 Antibodies (172) and T-Complex Protein 1 Proteins (4) and many more products for this protein.
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treating BACHD cortical neurons with ApiCCT1 prevented BACHD striatal neuronal atrophy by enhancing release of BDNF (show BDNF ELISA Kits) that subsequently acts through tyrosine receptor kinase B (TrkB (show NTRK2 ELISA Kits)) receptor on striatal neurons. Our findings are evidence that TRiC (show MARVELD2 ELISA Kits) reagent-mediated reductions in mHTT enhanced BDNF (show BDNF ELISA Kits) delivery to restore the trophic status of BACHD striatal neurons.
this study shows that CCTalpha is required for antigen-specific, germinal center-derived memory B cells
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 ELISA Kits) (P2X7R (show P2RX7 ELISA Kits)) and plays a role in lymphoid neoplasm metastasis.
The data presented here reveal an additional level of interplay between CCT and actin mediated via gelsolin (show GSN ELISA Kits), suggesting that CCT may influence processes depending on gelsolin (show GSN ELISA Kits) activity, such as cell motility.
Host CCTalpha is required for efficient transcription and replication of rabies virus.
Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia
Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.
Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.
TRiC-peptide complexes of the heat shock protein 60 family are efficient vehicles of cross-presentation in assays in vitro and in mice in vivo; immunization with TRiC purified from a tumor elicits specific protection against a challenge with that tumor.
downregulated expression in T cells following treatment with bis (show BAG3 ELISA Kits)(tri (show VANGL2 ELISA Kits)-n-butylin)oxide (TBTO), an immunotoxic organotin
multiple ankyloblepharon-ectodermal defects-cleft lip/palate syndrome-associated p63 (show RPE65 ELISA Kits) mutations, but not those causative of other diseases, lead to thermodynamic protein destabilization, misfolding, and aggregation
LINC01503 is increased in squamous cell carcinoma (SCC (show CYP11A1 ELISA Kits)) cells compared with non-tumor cells. TP63 (show TP63 ELISA Kits) bound to the super enhancer at the LINC01503 locus activates its transcription which promotes SCC (show CYP11A1 ELISA Kits) cell proliferation, migration, invasion, and growth of xenograft tumors.
we provide evidence that S100A7 (show S100A7 ELISA Kits) also inhibits YAP (show YAP1 ELISA Kits) expression and activity through p65/NFkappaB (show NFKB1 ELISA Kits)-mediated repression of DeltaNp63, and S100A7 (show S100A7 ELISA Kits) represses drug-induced apoptosis via inhibition of YAP (show YAP1 ELISA Kits).
DeltaNp63 promotes head and neck squamous cell carcinoma tumorigenesis via regulation of hyaluronic acid metabolism. p63 (show RPE65 ELISA Kits) expression is a negative prognostic factor of HNSCC patient survival.
cases illustrate that: there is significant familial variability, including discordant major but concordant minor anomalies in the first ever reported set of molecularly confirmed monozygotic twins with pathogenic variants in TP63 (show TP63 ELISA Kits).
results reveal a critical role for KMT2D (show MLL2 ELISA Kits) in the control of epithelial enhancers and p63 (show RPE65 ELISA Kits) target gene expression.
Loss of Nrf2 (show GABPA ELISA Kits) inhibits deltaNp63 stem cell mobilization, a key event for reconstitution of radiation-injured lung, while promoting a myofibroblast phenotype that is central for fibrosis.
PKC-delta (show PKCd ELISA Kits) played as a protective role in squamous cell carcinomas partly by down-regulating p63 (show RPE65 ELISA Kits), leading to the suppression of squamous cell carcinomas cell proliferation
Immunocytochemical staining using cocktail antibody targeting p63 (show RPE65 ELISA Kits)/CK14 (show KRT14 ELISA Kits) was useful for the differential diagnosis of FA and DCIS in FNAC of the breast.
Authors conclude that TP63 (show TP63 ELISA Kits) mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, T-complex protein 1 subunit alpha
, T-complex protein 1 subunit alpha A
, T-complex protein 1 subunit alpha B
, t-complex polypeptide 1
, tailless complex polypeptide 1A
, tailless complex polypeptide 1B
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, transformation related protein 63
, tumor protein 63 kDa