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TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping T-Complex Protein 1 Antibodies (173) and T-Complex Protein 1 Proteins (4) and many more products for this protein.
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chaperonin-containing TCP-1 (show CCT6A ELISA Kits) complex required for lysosomal functioning and autophagosome degradation
The authors identify and confirm interaction of M72 with the eukaryotic chaperonin tailless complex protein -1 (TCP-1) ring complex (TRiC) or chaperonin containing tailless complex polypeptide 1 (CCT). Accumulating biochemical evidence indicates M72 forms homo-oligomers and is a substrate of TRiC/CCT
treating BACHD cortical neurons with ApiCCT1 prevented BACHD striatal neuronal atrophy by enhancing release of BDNF (show BDNF ELISA Kits) that subsequently acts through tyrosine receptor kinase B (TrkB (show NTRK2 ELISA Kits)) receptor on striatal neurons. Our findings are evidence that TRiC (show MARVELD2 ELISA Kits) reagent-mediated reductions in mHTT enhanced BDNF (show BDNF ELISA Kits) delivery to restore the trophic status of BACHD striatal neurons.
this study shows that CCTalpha is required for antigen-specific, germinal center-derived memory B cells
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 ELISA Kits) (P2X7R (show P2RX7 ELISA Kits)) and plays a role in lymphoid neoplasm metastasis.
The data presented here reveal an additional level of interplay between CCT and actin mediated via gelsolin (show GSN ELISA Kits), suggesting that CCT may influence processes depending on gelsolin (show GSN ELISA Kits) activity, such as cell motility.
Host CCTalpha is required for efficient transcription and replication of rabies virus.
Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia
Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.
Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.
In leukoplakia, increased expression of survivin reflects on the increased expression of ki-67 (show MKI67 ELISA Kits) and p63 (show RPE65 ELISA Kits).
Gene-gene interaction between MSX1 (show MSX1 ELISA Kits) and TP63 (show TP63 ELISA Kits) may influence the risk of nonsyndromic cleft lip with or without cleft palate in Asian populations.
High N-terminally truncated isoform of p63 (show RPE65 ELISA Kits) expression is associated with squamous cell carcinogenesis.
The rs35592567 polymorphism in TP63 (show TP63 ELISA Kits) affected the expression of TP63 (show TP63 ELISA Kits) by interfering with its interaction with miR (show MLXIP ELISA Kits)-140, and could serve as an explanation for the increased risk of Gastric Cancer.
The data from this study showed that p63 was a tumor suppressor mainly through regulating PTEN in chondrosarcoma cells.
we first demonstrated that upregulation of P63 (show RPE65 ELISA Kits) in the cartilage tissues of osteoarthritis (OA) patients inhibited chondrocyte autophagy thereby contributing to the malignant progression of OA.
high DeltaNp63beta expression up-regulates KLK6 (show KLK1 ELISA Kits)-PAR2 (show F2RL1 ELISA Kits) and down-regulates PAR1, inducing malignant transformation in oral epithelium with stimulating proliferation through ERK (show EPHB2 ELISA Kits) signal activation
multiple ankyloblepharon-ectodermal defects-cleft lip/palate syndrome-associated p63 (show RPE65 ELISA Kits) mutations, but not those causative of other diseases, lead to thermodynamic protein destabilization, misfolding, and aggregation
LINC01503 is increased in squamous cell carcinoma (SCC (show CYP11A1 ELISA Kits)) cells compared with non-tumor cells. TP63 (show TP63 ELISA Kits) bound to the super enhancer at the LINC01503 locus activates its transcription which promotes SCC (show CYP11A1 ELISA Kits) cell proliferation, migration, invasion, and growth of xenograft tumors.
we provide evidence that S100A7 (show S100A7 ELISA Kits) also inhibits YAP (show YAP1 ELISA Kits) expression and activity through p65/NFkappaB (show NFKB1 ELISA Kits)-mediated repression of DeltaNp63, and S100A7 (show S100A7 ELISA Kits) represses drug-induced apoptosis via inhibition of YAP (show YAP1 ELISA Kits).
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, T-complex protein 1 subunit alpha
, T-complex protein 1 subunit alpha A
, T-complex protein 1 subunit alpha B
, t-complex polypeptide 1
, tailless complex polypeptide 1A
, tailless complex polypeptide 1B
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, transformation related protein 63
, tumor protein 63 kDa