T-Complex Protein 1 (TCP1) ELISA Kits

TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping T-Complex Protein 1 Antibodies (174) and T-Complex Protein 1 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
TCP1 21454 P11983
TCP1 8626 Q9H3D4
TCP1 246334 Q9JJP6
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Top T-Complex Protein 1 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human
  2 x 96 Tests Log in to see 2 to 3 Days
$480.00
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Human
  2 x 96 Tests Log in to see 2 to 3 Days
$480.00
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Human
  96 Tests Log in to see 2 to 3 Days
$495.00
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More ELISA Kits for T-Complex Protein 1 Interaction Partners

Mouse (Murine) T-Complex Protein 1 (TCP1) interaction partners

  1. chaperonin-containing TCP-1 complex required for lysosomal functioning and autophagosome degradation

  2. The authors identify and confirm interaction of M72 with the eukaryotic chaperonin tailless complex protein -1 (TCP-1) ring complex (TRiC) or chaperonin containing tailless complex polypeptide 1 (CCT). Accumulating biochemical evidence indicates M72 forms homo-oligomers and is a substrate of TRiC/CCT

  3. treating BACHD cortical neurons with ApiCCT1 prevented BACHD striatal neuronal atrophy by enhancing release of BDNF that subsequently acts through tyrosine receptor kinase B (TrkB) receptor on striatal neurons. Our findings are evidence that TRiC reagent-mediated reductions in mHTT enhanced BDNF delivery to restore the trophic status of BACHD striatal neurons.

  4. this study shows that CCTalpha is required for antigen-specific, germinal center-derived memory B cells

  5. Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (P2X7R) and plays a role in lymphoid neoplasm metastasis.

  6. The data presented here reveal an additional level of interplay between CCT and actin mediated via gelsolin, suggesting that CCT may influence processes depending on gelsolin activity, such as cell motility.

  7. Host CCTalpha is required for efficient transcription and replication of rabies virus.

  8. Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia

  9. Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.

  10. Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.

  11. TRiC-peptide complexes of the heat shock protein 60 family are efficient vehicles of cross-presentation in assays in vitro and in mice in vivo; immunization with TRiC purified from a tumor elicits specific protection against a challenge with that tumor.

  12. the membrane binding domain of CTP:phosphocholine cytidylyltransferase has a role in alveolar type II cells

  13. downregulated expression in T cells following treatment with bis(tri-n-butylin)oxide (TBTO), an immunotoxic organotin

  14. cellular distribution of CCT during spermatogenesis; in the cytoplasm,it associates to the microtubule organizing center and the manchette; in the nucleus, it concentrates at highly condensed chromatin regions

Human T-Complex Protein 1 (TCP1) interaction partners

  1. Cullin3/KCTD5 downregulates the DNA-binding affinity of DeltaNp63alpha, impairing either its transactivity or its transinhibitory activity. Functionally, Cullin3/KCTD5 abates the proproliferation activity of DeltaNp63alpha. These findings suggest that KCTD5-based CRL3 may mediate monoubiquitination and is a novel regulator of DeltaNp63alpha.

  2. Letter: loss of TP63/TRP63 directly facilitates cutaneous squamous cell carcinoma development and progression through activation of Wnt/beta-catenin signaling.

  3. P63alpha inhibited cyclin D1 protein expression.

  4. Exogenous p51A gene can increase its expression in A549 and NCI-H1299 cells, suppress cell growth and induce cell apoptosis. Moreover, it can also cooperate with chemotherapy and reduce the dose and side-effect. p51A gene can suppress tumours in spite of p53 status and p21 gene might be involved.

  5. Case Report: TP63 mutation responsible for ankyloblepharon-ectodermal defects-cleft lip/palate-syndrome with choanal atresia and skin erosions.

  6. Thus, epithelial barrier and ciliogenesis of nasal epithelium are regulated in a p63-negative manner in normal and upper airway diseases.

  7. Letter/Case Report: heterozygous mutation in the SAM domain of the TP63 gene resulting in mild form of ectodermal dysplasia.

  8. ATDC is required for TP63-induced bladder tumor invasion and metastasis.

  9. Expression of p63 was not elevated in gestational trophoblastic disease

  10. Study reinforces that p63 is a crucial gene for maintaining epithelial tissue integrity and support the deregulation of the cell-cell adhesion program, which plays a critical role in squamous cell carcinoma development.

  11. Data indicate keratins K5/K14 and p53 homolog p63 as markers of breast epithelial stem cells.

  12. The mutation was not previously described in the literature or databases and should be included into these as probably pathogenic. A multidisciplinary approach is necessary to care for a patient with Hay-Wells syndrome, such care however can provide good results.

  13. Mechanistically, Delta133p53 binds to DeltaNp63 and utilizes its transactivation domain to upregulate GLUT1, GLUT4, and PGM expression driving glycolysis. While increased glycolysis provides cancer cells with anabolic metabolism critical for proliferation and survival, it can be harnessed for selective cancer cell killing.

  14. Study investigates the biological significance of the Rbm38-p63 loop and finds that Rbm38 and p63 function as intergenic suppressors in aging and tumorigenesis.

  15. ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation.

  16. TP63 role in the squamous cancer progression.CCAT1 is a key target co-regulated by TP63 and SOX2 through a super-enhancer in squamous cancer cells.

  17. lncRNA RP185F18.6 and DeltaNp63 may be considered unfavorable biomarkers, whereas GSDMD may be a favorable biomarker in colorectal cancer (CRC) ; these markers may prove valuable in the future diagnosis and prognosis of CRC.

  18. Data identified an enhancer region within the TP63/LEPREL1 locus containing genetic variants associated with bladder cancer risk.

  19. The malignant lesions showed significantly lower values than the benign lesions in the percentage of p63+ clusters, the percentage of p63+ single cells in the clusters, and the number of p63+ single cells in the background.

  20. Expression of TAp63, IKKbeta and XBP1s is also increased in livers of obese patients with liver steatosis .

T-Complex Protein 1 (TCP1) Antigen Profile

Antigen Summary

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Gene names and symbols associated with T-Complex Protein 1 (TCP1) ELISA Kits

  • t-complex protein 1 (Tcp1) antibody
  • tumor protein p63 (TP63) antibody
  • tumor protein p63 (Tp63) antibody
  • AI528772 antibody
  • AIS antibody
  • B(p51A) antibody
  • B(p51B) antibody
  • c-cpn antibody
  • CCT antibody
  • Cct1 antibody
  • Ccta antibody
  • EEC3 antibody
  • Ket antibody
  • LMS antibody
  • NBP antibody
  • OFC8 antibody
  • p40 antibody
  • p51 antibody
  • p53CP antibody
  • p63 antibody
  • p73H antibody
  • P73l antibody
  • RHS antibody
  • SHFM4 antibody
  • Tcp-1 antibody
  • TP53CP antibody
  • TP53L antibody
  • Tp63 antibody
  • Tp73l antibody
  • TRic antibody
  • Trp63 antibody

Protein level used designations for T-Complex Protein 1 (TCP1) ELISA Kits

CCT-alpha , T-complex protein 1 subunit alpha , T-complex protein 1 subunit alpha A , T-complex protein 1 subunit alpha B , TCP-1-A , TCP-1-B , TCP-1-alpha , t-complex polypeptide 1 , tailless complex polypeptide 1A , tailless complex polypeptide 1B , CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , transformation-related protein 63 , tumor protein 63 , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , transformation related protein 63 , tumor protein 63 kDa

GENE ID SPECIES
21454 Mus musculus
8626 Homo sapiens
246334 Rattus norvegicus
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