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TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. Additionally we are shipping TBC1D1 Antibodies (47) and TBC1D1 Proteins (4) and many more products for this protein.
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the TBC1D1 gene has an effect on meat, carcass and production traits in Italian heavy pigs.
TBC1D1-Ser (show SIGLEC1 ELISA Kits)(231) phosphorylation and/or 14-3-3 (show YWHAQ ELISA Kits) binding partially mediates AMPK (show PRKAA1 ELISA Kits)-governed glucose homeostasis and muscle glucose uptake in a context-dependent manner.
data demonstrate heterozygous deactivating TBC1D1 mutations in CAKUT patients with a similar renal and ureteral phenotype, and provide evidence that TBC1D1 mutations may contribute to CAKUT
AS160 and TBC1D1 phosphorylations were evident 30 min after exercise.
Data show that TBC1D1 is expressed and phosphorylated in response to glucose in these cells.
Moderate association of rs9852 indicates an influence of TBC1D1 for antipsychotic-induced weight gain.
R125W mutation occurs in a location of the TBC1D1 PTB (show PTBP1 ELISA Kits) domain that is predicted to have a function in a putative protein:protein interaction.
Data suggest that insulin (show INS ELISA Kits) increases phosphorylation of signaling nexus TBC1D1 independent of prior exercise or lipid/Intralipid administration.
TBC1D1 is Ser237 phosphorylated and binding capacity to 14-3-3 protein is increased in skeletal muscle following exercise.
[review] The question of a mechanism for increased phosphorylation of Se (show APRT ELISA Kits)r237-TBC1D1 after exercise has, so far, not had a straightforward experimental approach for a direct answer in humans undergoing in vivo exercise.
A single bout of exercise regulates TBC1D1 and AS160 phosphorylation on multiple sites in human skeletal muscle.
in obese leptin (show LEP ELISA Kits)-deficient mice, lack of TBC1D1 has no impact on feeding behavior or energy intake but results in increased energy expenditure, altered energy substrate preference with increased fatty acid oxidation and suppression of obesity; TBC1D1 may have an evolutionary conserved role in regulating energy homeostasis in vertebrates
These findings demonstrate that the AMPK (show PRKAA1 ELISA Kits)-TBC1D1 signaling nexus interacts with the PKB (show AKT2 ELISA Kits)-mTOR (show FRAP1 ELISA Kits) pathway via IGF1 (show IGF1 ELISA Kits) secretion, which consequently controls expression of lipogenic genes in the adipose tissue
Rab28 is a substrate for the GAP domains of both TBC1D1 and TBC1D4 in vitro.
Tbc1d1 knockout mice have GLUT4 (show SLC2A4 ELISA Kits) expression and glucose uptake defects in skeletal muscle and adipose tissue. These defects combine in AS160 KO/Tbc1d1 KO mice, supporting nonredundant functions for AS160 and Tbc1d1.
Data (including data from mice with Tbc1d1 gene deletion) suggest Tbc1d1 controls basal intracellular GLUT4 (show SLC2A4 ELISA Kits) retention in large skeletal muscles; in small muscles (extensor digitorum longus) Tbc1d1 does not regulate basal GLUT4 (show SLC2A4 ELISA Kits) cell surface exposure.
Findings indicate that the RabGAP TBC1D1 plays a key role in regulating GLUT4 (show SLC2A4 ELISA Kits) protein levels and in exercise-mediated glucose uptake in nonoxidative muscle fibers.
TBC1D1-mediated reduction of muscle fatty acid oxidation appears to occur via inhibition of beta-hydroxyaacyl-CoA dehydrogenase activity.
Data from knockout mice suggest that Tbc1d1 is involved in regulation of energy substrate metabolism (glucose vs. lipids) and energy homeostasis; Tbc1d1 plays important role in susceptibility to diabetes type 2, obesity, and hypertriglyceridemia.
Tbc1d1 serves as a key regulator of aminoimidazole carboxamide ribonucleotide-induced GLUT4 (show SLC2A4 ELISA Kits) liberation
It was shown that TBC1D1 plays a role in regulation of glucose metabolism in skeletal muscle. Moreover, functional TBC1D1 was required for AICA ribonucleotide- or contraction-induced metabolic responses.
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6\; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
, TBC1 domain family member 1-like
, TBC1 domain family member 1
, TBC1 domain family, member 1
, tre-2/USP6, BUB2, cdc16) domain family, member 1