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The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. Additionally we are shipping TH1-Like (Drosophila) Antibodies (53) and TH1-Like (Drosophila) Proteins (5) and many more products for this protein.
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A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B. NELF-B is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E, which is confirmed to bind RNA in vivo.
data show that NELF subunits exhibit highly specific subcellular localizations, such as in NELF bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF from cells can lead to enlarged and/or multiple nuclei
Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration.
TH1 might play an important role in regulation of proliferation and invasion in human breast cancer.
These results indicate that TH1 is a novel regulator to control the duration and magnitude of androgen signal transduction and might be directly involved in androgen-related developmental, physiological, and pathological processes.
diverse transcriptional consequence of NELF-mediated RNAPII pausing in the human genome
In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf.
NELF-C and NELF-D are highly related or identical to the protein called TH1, of unknown function. NELF-B and NELF-C or NELF-D are integral subunits that bring NELF-A and NELF-E together. [NELF-B] [NELF-C]
Trihydrophobin 1 negatively regulates A-Raf kinase
A study was done of ubiquitin-dependent proeolysis of TH1L protein by E6-AP.
Negative elongation factor (NELF) is a four subunit transcription factor. Our results point to a surprising role of NELF in the 3' end processing of histone mRNAs and suggest that NELF is a new factor that coordinates mRNA processing in transcription.
Maternal serum Th1 cytokines concentrations increase in preterm and term delivery.
TH1 interacts with PAK1 and specifically restricts the activation of MAPK modules through the upstream region of the MAPK pathway, thereby influencing cell migration.
results indicated that Nrf2 protects against the development of pulmonary fibrosis by regulating the cellular redox level and lung Th1/Th2 balance.
The gene expression of TH1 in mouse testis and changes of TH1 protein during postnatal development, were analyzed.
In conclusion, our data suggest that RelB is an important target for morphine modulation of proinflammatory and Th1 cytokines. They also indicate that morphine uses multiple intracellular pathways to exert its generalized immunosuppression.
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.
, TH1 drosophila homolog
, TH1-like protein
, negative elongation factor C/D
, negative elongation factor proteins C and D
, trihydrophobin 1
, TH1 homolog
, TH1-like homolog
, negative elongation factor D
, trihydrophobin 1 homolog
, negative elongation factor complex member C/D,Th1l
, negative elongation factor D-like