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Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
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Hemokinin-1, but not substance P (show TAC1 Antibodies) increases inflammation and hyperalgesia in the late phase of adjuvant-induced arthritis.
These findings suggest that tachykinins and NK1 (show HGF Antibodies) receptors play a key role in joint inflammation, rather than in nociceptive sensitization, in collagen antibody-induced arthritis A.
Our findings suggest a role for TAC4 in cell differentiation, and represent a regulatory bridge between the nervous system and the immune system.
cultures from TAC4(-/-) bone marrow, sorted "fraction B" pro-B cells or purified long-term reconstituting stem cells, contain higher numbers of pro-B cells compared with controls, suggesting an inhibitory role for HK-1 (show HK1 Antibodies) on developing B cells
Preprotachykinin (show TAC1 Antibodies) (PPT)-C genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function.
HK-1 (show HK1 Antibodies) influences T-cell development, enhancing the proliferation of T-cell precursors and increased the number of thymocytes in fetal thymus organ cultures
Here we demonstrate the expression of mouse PPT-C (hemokinin 1 precursor) mRNA by CD11b (show ITGAM Antibodies)+ macrophages, CD11c (show ITGAX Antibodies)+ dendritic cells and in the microglial cell line EOC 13.31.
mouse hemokinin 1 and mouse hemokinin 1(2-11) are tachykinin NK(1) receptor (show TACR1 Antibodies)-preferring uterotonic agonists in non-pregnant mice but lack action at the myometrial tachykinin NK(2 (show HGF Antibodies)) receptors present in late pregnant mice
Results suggest that Hemokinin-1 is regulated by a unique transcription regulation system that likely governs its differential expression pattern and suggests a role for Hemokinin-1 distinct from Substance P (show TAC1 Antibodies).
Kinase activation led to increased MMP-2 (show MMP2 Antibodies) and MT1-MMP (show MMP14 Antibodies) expression and melanoma cell migration induced by hHK-1 (show HOOK1 Antibodies). Thus, hHK-1 (show HOOK1 Antibodies) and the NK1 receptor (show TACR1 Antibodies) are critical to melanoma cell migration and each may be a promising chemotherapeutic target
Expression substance P/neurokinin A (show TAC1 Antibodies)/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 (show TAC1 Antibodies) receptors are dysregulated in uterine leiomyomata.
Data provide evidence for the first time that hemokinin-1, like substance P (show TAC1 Antibodies), may be involved in the pathophysiology of inflammatory bowel disease.
HK-1 (show KCNA4 Antibodies) and substance P (show TAC1 Antibodies) are novel T helper (Th)17 cell-inducing factors that may act locally on memory T cells to amplify inflammatory responses.
hHK-1 (show HOOK1 Antibodies) and its C-terminal fragments are human NK1 receptor (show TACR1 Antibodies) agonists with different functional selectivity properties and that such functional selectivity leads to differential activation of downstream signaling and receptor trafficking.
A possible association is found between a tachykinin-4 single nucleotide polymorphism and susceptibility to asthma.
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS- stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor.
hemokinin I (HK-1)
, alpha tachykinin 4