Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Proteins (TNKS2)

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Additionally we are shipping Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Antibodies (71) and Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNKS2 80351 Q9H2K2
TNKS2 74493 Q3UES3
Rat TNKS2 TNKS2 309512  
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Top Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human TNKS2 Protein. 100 μg Log in to see 11 to 18 Days
$582.75
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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TNKS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) Interaction Partners

Human Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) interaction partners

  1. CTIF was identified as a novel PARylation target of the TNKS2 in the centrosomal region of cells, which plays a role in the distribution of the centrosomal satellites.

  2. Either tankyrase 1 or 2 is sufficient to maintain telomere length, but both are required to resolve telomere cohesion and maintain mitotic spindle integrity. Tankyrases are required for Notch2 to exit the plasma membrane and enter the nucleus to activate transcription.

  3. Finally, through functional validation, we uncovered a role for TNKS/2 in peroxisome homeostasis and determined that this function is independent of TNKS enzyme activities.

  4. Polymerization is required for Tankyrase to drive beta-catenin-dependent transcription. The polymeric state supports PARP activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN binding.

  5. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  6. High TNKS2 expression is associated with breast cancer.

  7. The tumor suppressive activity of miR-490-3p is largely mediated through downregulation of TNKS2 and inactivation of beta-catenin signaling. Thus, miR-490-3p may represent a potential therapeutic target for triple-negative breast cancer.

  8. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt/beta-catenin signaling addicted tumors.

  9. rs1340420 SNP was associated with lower NSCLC risk, whereas rs1770474 SNP was associated with higher squamous-cell carcinoma risk

  10. Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC with aberrant WNT/beta-catenin signaling pathway.

  11. TNKS2 is recruited to DNA lesions by MDC1 and promotes homologous recombination in response to DNA double strand breaks.

  12. The variability of genes encoding for TERF1 and TNKS2 is important for keeping the integrity of the telomere structure and show a significant association with longevity.

  13. Studies show a significant interaction of IWR1 with acidic and polar residues (Asp and Tyr) in the hydrophobic region at the induced pocket of TNKS1/TNKS2. These two residues are the key for the mechanism of inhibition of TNKS proteins.

  14. Data indicate a basis for development of flavones as tankyrase inhibitors and suggest the development of other structurally related inhibitors.

  15. Data suggest that miR-20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2.

  16. Study reports crystal structures of a representative ankyrin repeat clusters of TNKS2 bound to targeting peptides from six substrates.

  17. RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins

  18. TNKS2 bound to Epstein-Barr virus origin of plasmid replication in coimmunoprecipitation experiments with transfected cell lysates.

  19. pathologic overexpression of tankyrase 2 in some tumors may be a result of the cancer-related adaptation of the malignant cells dependent on tankyrase activity.

  20. TNKL and TNKS are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients

Mouse (Murine) Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) interaction partners

  1. Study using Villin-creERT2;Tnks1-/-;Tnks2fl/fl mice, which harbored conventional Tnks1 deletion and inducible intestinal epithelium-specific Tnks2 knockout, shows that tankyrases regulate adult intestinal Lgr5+ stem cells and epithelium homeostasis by preventing cell death and promoting cell proliferation.

  2. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

  3. a new function of RNF146 and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT proteins at the apical membrane, is reported.

  4. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  5. TNKS2 is required in insulin-stimulated glucose disposal.

  6. Study shows that TNKS2, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation in osteoclasts; cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction.

  7. Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt ligands.

  8. inactivation of tankyrase 2 does not result in the alteration in telomere length when monitored through multiple generations of breeding, tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism.

  9. Tnks2 has a role in normal growth and development but is not essential for telomere length maintenance or telomere capping in mice.

  10. tankyrase 2is essential but redundant for mouse embryonic development

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) Protein Profile

Protein Summary

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (By similarity).$.

Gene names and symbols associated with TNKS2

  • tankyrase 2 (TNKS2)
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (Tnks2)
  • tankyrase 2 (Tnks2)
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (TNKS2)
  • tankyrase 2 (tnks2)
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog (tnks.S)
  • 5430432P15Rik protein
  • AA517131 protein
  • AI662480 protein
  • ARTD6 protein
  • PARP-5b protein
  • PARP-5c protein
  • PARP5B protein
  • PARP5C protein
  • pART6 protein
  • Tank2 protein
  • tankyrase-1 protein
  • tankyrase-2 protein
  • TNKL protein
  • tnks protein
  • TNKS-2 protein
  • tnks.L protein
  • tnks2 protein

Protein level used designations for TNKS2

ADP-ribosyltransferase diphtheria toxin-like 6 , TNKS-2 , TRF1-interacting ankyrin-related ADP-ribose polymerase 2 , poly [ADP-ribose] polymerase 5B , tankyrase 2 , tankyrase II , tankyrase-2 , tankyrase-like protein , tankyrase-related protein , tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 , tankyrase-2-like , LOW QUALITY PROTEIN: tankyrase-2 , tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase L homeolog , tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog

GENE ID SPECIES
80351 Homo sapiens
74493 Mus musculus
309512 Rattus norvegicus
374253 Gallus gallus
533901 Bos taurus
698050 Macaca mulatta
100061968 Equus caballus
100391147 Callithrix jacchus
100539557 Meleagris gallopavo
100567928 Anolis carolinensis
100591011 Nomascus leucogenys
100154520 Sus scrofa
100855568 Canis lupus familiaris
100719373 Cavia porcellus
495279 Xenopus laevis
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