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Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking.
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Finally, through functional validation, we uncovered a role for TNKS/2 in peroxisome homeostasis and determined that this function is independent of TNKS (show TNKS Proteins) enzyme activities.
Polymerization is required for Tankyrase to drive beta-catenin (show CTNNB1 Proteins)-dependent transcription. The polymeric state supports PARP activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN (show AXIN1 Proteins) binding.
These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.
High TNKS2 expression is associated with breast cancer.
The tumor suppressive activity of miR (show MLXIP Proteins)-490-3p is largely mediated through downregulation of TNKS2 and inactivation of beta-catenin (show CTNNB1 Proteins) signaling. Thus, miR (show MLXIP Proteins)-490-3p may represent a potential therapeutic target for triple-negative breast cancer.
Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (show PARP1 Proteins)/2 and tankyrase 1 (show TNKS Proteins)/2 inhibitor which has the advantage of targeting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling addicted tumors.
Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC (show FAM126A Proteins) with aberrant WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.
TNKS2 is recruited to DNA lesions by MDC1 and promotes homologous recombination in response to DNA double strand breaks.
The variability of genes encoding for TERF1 (show TERF1 Proteins) and TNKS2 is important for keeping the integrity of the telomere structure and show a significant association with longevity.
Studies show a significant interaction of IWR1 with acidic and polar residues (Asp (show ASIP Proteins) and Tyr (show TYR Proteins)) in the hydrophobic region at the induced pocket of TNKS1 (show TNKS Proteins)/TNKS2. These two residues are the key for the mechanism of inhibition of TNKS (show TNKS Proteins) proteins.
Tank1 (show TNKS Proteins)/Tank2 inhibition aggravates kidney injury in the absence of CD2AP (show Cd2ap Proteins).
a new function of RNF146 (show RNF146 Proteins) and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT (show AMOT Proteins) proteins at the apical membrane, is reported.
TNKS2 is required in insulin (show INS Proteins)-stimulated glucose disposal.
Study shows that TNKS2, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation in osteoclasts; cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction.
Data show that Tnks1 (show TNKS Proteins) and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt (show WNT2 Proteins) ligands.
inactivation of tankyrase 2 does not result in the alteration in telomere length when monitored through multiple generations of breeding, tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism.
Tnks2 has a role in normal growth and development but is not essential for telomere length maintenance or telomere capping in mice.
tankyrase 2is essential but redundant for mouse embryonic development
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (By similarity).$.
ADP-ribosyltransferase diphtheria toxin-like 6
, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
, poly [ADP-ribose] polymerase 5B
, tankyrase 2
, tankyrase II
, tankyrase-like protein
, tankyrase-related protein
, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
, LOW QUALITY PROTEIN: tankyrase-2
, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase L homeolog
, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog