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The protein encoded by TSPAN3 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.
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A comprehensive comparative analysis of the expression profiles of the tetraspanins Tspan3 (Tm4sf8), Tspan4 (Tm4sf7 (show TSPAN4 Antibodies)) Tspan7 (Tm4sf2 (show TSPAN7 Antibodies)), and Tspan5 (Tm4sf9 (show TSPAN5 Antibodies)) during development in X. laevis.
Tspan3 is a central endocytic membrane component regulating the expression of ADAM10 (show ADAM10 Antibodies), presenilin and the amyloid precursor protein (show APP Antibodies).
Studies indicate that tetraspanin 3 has a critical role in acute myeloid leukemia (show BCL11A Antibodies).
Tspan3 is an important regulator of aggressive leukemias.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described.
, tyrosine-protein kinase SgK269
, tetraspan 3
, tetraspan TM4SF
, tetraspanin TM4-A
, transmembrane 4 superfamily member 8
, H41D4 protein
, OSP-associated protein 1
, tetraspanin TM4-A homolog