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The protein encoded by TSPAN8 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping Tetraspanin 8 Proteins (7) and Tetraspanin 8 Kits (1) and many more products for this protein.
Showing 10 out of 89 products:
Human Monoclonal Tetraspanin 8 Primary Antibody for IF, ELISA - ABIN563195
Zhou, Ran, Hu, Pan, Li, Chen, Sun, Peng, Zhao, Yu, Sun, Yang: TM4SF3 promotes esophageal carcinoma metastasis via upregulating ADAM12m expression. in Clinical & experimental metastasis 2008
Human Polyclonal Tetraspanin 8 Primary Antibody for IF (p), IHC (p) - ABIN716246
Bhansali, Zhou, Shemshedini: TM4SF3 and AR: A Nuclear Complex that Stabilizes Both Proteins. in Molecular endocrinology (Baltimore, Md.) 2016
Human Polyclonal Tetraspanin 8 Primary Antibody for ELISA, WB - ABIN4250045
Grarup, Andersen, Krarup, Albrechtsen, Schmitz, Jørgensen, Borch-Johnsen, Hansen, Pedersen et al.: Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a ... in Diabetes 2008
Mouse (Murine) Monoclonal Tetraspanin 8 Primary Antibody for FACS - ABIN4898916
Fu, Rios, Pal, Law, Jamieson, Liu, Vaillant, Jackling, Liu, Smyth, Lindeman, Ritchie, Visvader: Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive. in Nature cell biology 2017
overexpression of tm4sf3 promoted development of annular pancreas.
TSPAN8 mediated Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway through binding to NOTCH2 (show NOTCH2 Antibodies). The role of TSPAN8 in the drug resistance of gastric cancer.
these data point to a crucial role of Co-029 in the modulation of colon cancer cell motility which could be related to the protumoral effect reported for this tetraspanin. Among surface molecules able to mediate Co-029 function, E-cadherin (show CDH1 Antibodies), EGFR (show EGFR Antibodies) and CD44 (show CD44 Antibodies) appear as likely candidates.
Single nucleotide polymorphism in TSPAN8 gene is associated with pathogenesis of bipolar disorder.
Tetraspanin-8 has a role in promoting hepatocellular carcinoma metastasis by increasing ADAM12m expression
LCMR1 (show MED19 Antibodies) modulation was sufficient to positively regulate endogenous Tspan8 expression, with concomitant in vitro phenotypic changes such as loss of melanoma cell-matrix adherence and increase in invasion, and Tspan8 expression promoted tumourigenicity in vivo.
Data indicate a regulatory role for tetraspanin 8 (Tspan8) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK (show ILK Antibodies)) axis and establish Tspan8 as a negative regulator of ILK (show ILK Antibodies) activity.
TSPAN8 might be important for the orchestration of meprin beta (show MEP1B Antibodies) at the cell surface with impact on certain proteolytic processes
Knocking down TSPAN8 in AEG-1 (show MTDH Antibodies)-overexpressing human hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells markedly inhibited invasion and migration without affecting proliferation. TSPAN8 knockdown profoundly abrogated AEG-1 (show MTDH Antibodies)-induced primary tumor and intrahepatic metastasis in an orthopic xenograft model in athymic nude mice
Knockdown and knockout models revealed that CD151 (show CD151 Antibodies) and Tspan8 act as molecular facilitators in wound healing, angiogenesis and tumor progression. [review]
Results provide evidence that TSPAN8 may contribute to the pathogenesis of lung cancer by promoting cell viability and proliferation.
Transplantation studies provided definitive evidence that a TSPAN8-high subpopulation is enriched for spermatogonial stem cells.
results argue for a role for Tspan8 in body-weight regulation in males, but do not show differences in T2D-associated traits that were anticipated from previous human genome-wide association studies.
Results suggest that alterations in gene expression of Gata6, Tspan8, S100a8, and Lmo2 may act via novel pathways that play functionally important roles in Men1-associated tumor progression.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.
, transmembrane 4 superfamily member 3
, tumor-associated antigen CO-029