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TOLLIP encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. Additionally we are shipping TOLLIP Antibodies (164) and TOLLIP Kits (10) and many more products for this protein.
Showing 10 out of 17 products:
Our data suggest that Tollip SNP rs5743899 may predict varying airway response to RV infection in asthma.
pharmacogenetic analysis of patients enrolled in an idiopathic pulmonary fibrosis (IPF) clinical trial identified a variant within TOLLIP to be associated with differential response to N-acetylcysteine therapy.
study to examine potential associations between a selection of SNPs in the genes encoding TLR2 and TOLLIP, and predisposition, severity and outcome of Staphylococcus aureus bloodstream infections (SABSI); the TLR2 and TOLLIP polymorphisms were not associated with susceptibility to SABSI, severity, 30-day all-cause mortality, or SABSI caused by the clonal complex 30 genotype
Toll-interacting protein (TOLLIP) is a ubiquitin-binding protein that regulates innate immune responses.
Knock-down of Tollip promotes HIV-1 reactivation from latency.
Toll-interacting protein rs5743867 polymorphism tends to decrease the risk of sepsis in infants undergoing complex open heart surgery.
Variants in the TOLLIP gene are associated with higher circulating PAI-1 (show SERPINE1 Proteins) plasma levels and association with clinical Primary Graft Dysfunction Risk.
Tom1 (show TOM1 Proteins) modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism.
These data suggest that M. leprae upregulates IL-1Ra (show IL1RN Proteins) by a TOLLIP-dependent mechanism; inhibition of TOLLIP may decrease an individual's susceptibility to leprosy and offer a novel therapeutic target for IL-1 (show IL1A Proteins)-dependent diseases.
Observed expression patterns of several TLR inhibitory proteins with a noticeable suppression in expression of two of these; PPARgamma (show PPARG Proteins) and TOLLIP in both ulcerative colitis and Crohn's disease and in both active and inactive disease states.
Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 (show EFNA2 Proteins) Expression
Tollip deficiency selectively leads to enlarged yet stable atherosclerotic plaques, increased circulating lipids, liver steatosis, and reduced inflammation. Compromised lipophagy and reduced expression of inflammatory mediators due to Tollip deficiency may be the underlying causes.
This study demonstrated that a critical role of Tollip in the early phase of TLR4 (show TLR4 Proteins)-mediated neuroinflammation.
Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt (show AKT1 Proteins) signalling.
TOLLIP contributes to mortality following myocardial infarction through promoting inflammation and apoptosis
Data show that histone lysine methyltransferase Ezh1 (show EZH1 Proteins) promotes toll (show TLR4 Proteins)-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip), contributing to full activation of the innate immunity.
Overall, our data show an essential role for Tollip on colitis susceptibility in mice.
negative regulator of pathological cardiac hypertrophy by blocking the AKT (show AKT1 Proteins) signalling pathway
Tollip cooperates with Smad7 (show SMAD7 Proteins) to modulate intracellular trafficking and degradation of ubiquitinated TbetaRI (show TGFBR1 Proteins), whereby negatively regulates TGF-beta (show TGFB1 Proteins) signaling pathway.
DNA and protein coimmunization induces regulatory dendritic cells through caveolin-1 (show CAV1 Proteins)- and Tollip-mediated negative signaling.
identified two closely related Tollip-encoding genes in Atlantic salmon (Salmo salar)
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase.
, toll interacting protein
, adapter protein
, toll-interacting protein B
, toll-interacting protein A
, Toll-interleukin 1 receptor interacting protein