anti-Torsin Family 1, Member A (Torsin A) (TOR1A) Antibodies

The protein encoded by TOR1A is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Additionally we are shipping Torsin Family 1, Member A (Torsin A) Proteins (10) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TOR1A 266606  
TOR1A 1861 O14656
TOR1A 30931 Q9ER39
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Torsin Family 1, Member A (Torsin A) Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using TOR1A antibody. 100 μL Log in to see 16 Days
$366.77
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of MCF-7, using TOR1A antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277058 at 1/100 staining Mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB TOR1A Antibody (C-term)  western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the TOR1A antibody detected the TOR1A protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated WB Western blot analysis of extracts of SH-SY5Y cell line, using TOR1A antibody. Western blot analysis of extracts of various cell lines, using TOR1A antibody (ABIN4905463) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Mouse IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s. 100 μL Log in to see 16 Days
$366.77
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant TOR1A, Human. Figure. DAB staining on IHC-P; Samples: Human Prostate Gland Cancer Tissue. 100 μg Log in to see 15 to 18 Days
$350.00
Details
Human Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of recombinant Human TOR1A. IHC-P analysis of Human Prostate Gland Cancer Tissue, with DAB staining. 100 μg Log in to see 11 to 18 Days
$440.62
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 11 to 18 Days
$369.55
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using TOR1A antibody (ABIN5995890) at 1/1000 dilution. 100 μL Log in to see 11 to 16 Days
$412.19
Details

More Antibodies against Torsin Family 1, Member A (Torsin A) Interaction Partners

Human Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. TorsinA was post-transcriptionally upregulated upon acute ER stress, suggesting a role in this response. Increased basal phosphorylation of eIF2alpha in DYT1 transgenic rats was associated with abnormal response to acute ER stress. Unbiased RNA-Seq-based transcriptomic analysis of embryonic brain tissue in heterozygous and homozygous DYT1 knockin mice confirmed presence of eIF2alpha dysregulation in the DYT1 brain.

  2. Association between rs35153737 TOR1A variant and dystonia in a southwestern Chinese population.

  3. TOR1A exon 5 c.*302T>A is associated with isolated dystonia in southwestern Chinese.

  4. TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models

  5. This study does not allow the establishment of genotype-specific clinical correlations for DYT1 in patient with isolated dystonia.

  6. This study show both MDYT1 and without clinical symptoms showed an abnormally enhanced Abnormal blink reflex recovery curve compared with the healthy controls. Moreover, the lack of a statistical difference between manifesting and nonmanifesting carriers suggests that their brainstem circuits are equivalently affected by the DYT1. gene

  7. A comparison of these structures shows, in atomic detail, the subtle differences in TorsinADeltaE-LULL1 activator interactions that separate the healthy from the diseased state.

  8. found that human Torsin1A and human FMRP were present in the same protein complexes, suggesting that this phenomenon is evolutionarily conserved

  9. The significant association of rs1182 and rs1801968 TOR1A variants was found in the development of focal dystonia and writer's cramp respectively.

  10. This study demonstrated that whole-exome sequencing show reveled TOR1A mutation with early-onset generalized dystonia.

  11. This study showed that the Phosphodiesterase-10A Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia.

  12. Genetic screening targeted at currently known disease-causing mutations in TOR1A, THAP1, and TUBB4 appears to have low diagnostic yield in sporadic spasmodic dysphonia. In our cohort, only 2 patients tested positive for novel/rare variants in THAP1.

  13. there might not be an association between TOR1A or THAP1 and patients with adult-onset primary focal dystonia

  14. This processing occurs not only in stress-exposed cell lines but also in primary cells from distinct organisms including stimulated B cells, indicating that Torsin conversion in response to physiologically relevant stimuli is an evolutionarily conserved process.

  15. Our patient and three other reported carriers of non-c.907_909delGAG-mutations within the first three exons of TOR1A showed similar phenotypes of adult-onset focal or segmental cervical dystonia

  16. Plasma salusin-alpha and salusin-beta levels are increased in endometrioma patients and positively correlated with endometrioma size.

  17. the common rs2296793 and rs3842225 SNPs of TOR1A do not play a major role in cervical dystonia in a Chinese population.

  18. Certain TOR1A genotypes may be regarded as factors predisposing to focal and segmental dystonia.

  19. DYT1 mutations are associated with dystonia disorders

  20. TorA(DeltaE) in Drosophila brains may activate the UPR and increase the expression of HSP22 to compensate for the toxic effects

Mouse (Murine) Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. These findings are the first to demonstrate a cell autonomous requirement for torsinA in specific populations of cholinergic neurons, strengthening the connection between torsinA, cholinergic dysfunction and dystonia pathophysiology

  2. findings support a role for torsinA function in neuronal nuclear pore biogenesis during neuronal maturation and implicate altered NPC function in dystonia pathophysiology.

  3. TorsinA was post-transcriptionally upregulated upon acute ER stress, suggesting a role in this response. Increased basal phosphorylation of eIF2alpha in DYT1 transgenic rats was associated with abnormal response to acute ER stress. Unbiased RNA-Seq-based transcriptomic analysis of embryonic brain tissue in heterozygous and homozygous DYT1 knockin mice confirmed presence of eIF2alpha dysregulation in the DYT1 brain.

  4. Results show that direct pathological insult to forebrain torsinA in a symptomatic mouse model of DYT1 dystonia can engage genetically normal hindbrain regions into an aberrant connectivity network. These findings have important implications for the assignment of a causative region in CNS disease.

  5. that the deletion of a 3-base pair (DeltaGAG) sequence in the Dyt1 gene encoding torsinA has network level effects on in vivo functional connectivity and microstructural integrity across the sensorimotor cortex, basal ganglia, and cerebellum

  6. TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models

  7. Abnormal motor symptoms in DYT1 knockdown animals were associated with irregular cerebellar output caused by changes in the intrinsic activity of both Purkinje cells and neurons of the deep cerebellar nuclei.

  8. Purkinje cells (PC) express high levels of TA also in the spines and axonal terminals. In addition, abundant expression of the protein was found in the main GABA-ergic and glutamatergic inputs of the cerebellar cortex. Finally, TA was observed also in glial cells, a cellular population little explored so far. These results extend our knowledge on TA synaptic localization providing a clue to its potential role in synaptic

  9. Study linked the genetic defect of reduced torsinA expression in a DYT1 related mouse model to a maladaptive response of the striatal dopaminergic system after a peripheral nerve lesion and to the manifestation of dystonia-like movements

  10. The nuclear envelope-localized AAA+ (ATPase associated with various cellular activities) torsinA (TA) and its activator, the inner nuclear membrane protein lamina-associated polypeptide 1 (LAP1), are required for rearward nuclear movement.

  11. This processing occurs not only in stress-exposed cell lines but also in primary cells from distinct organisms including stimulated B cells, indicating that Torsin conversion in response to physiologically relevant stimuli is an evolutionarily conserved process.

  12. Authors find no effect of this anatomic-specific expression of the DYT1 genotype.

  13. The data suggest that LULL1 oligomerizes to engage and transiently disassemble torsinA oligomers, and is thereby positioned to transduce cytoplasmic signals to the inner nuclear membrane through torsinA.

  14. These findings demonstrate that dorsal dorsal striatal large cholinergic interneurons have a unique requirement for torsinA function during striatal maturation, and link abnormalities of these cells to dystonic-like movements.

  15. maintaining an appropriate torsinA level is important to sustain normal motor performance, synaptic transmission and plasticity

  16. Dyt1 KI mice exhibit decreased striatal dopamine receptor 1 binding activity and D1R protein levels, suggesting the alteration of the direct pathway. We developed a novel motor skill transfer test for mice and found deficits in Dyt1 KI mice.

  17. cellular and molecular framework for how impaired torsinA function selectively disrupts neural circuits and raise the possibility that discrete foci of neurodegeneration may contribute to the pathogenesis of DYT1 dystonia

  18. Results reveal subtle structural changes of the cerebellum that are similar to those reported for the basal ganglia in the DYT1 knock-in mouse model.

  19. the mutation only slightly increases the excitability of striatal GABAergic neurons in DYT1 dystonia.

  20. detected differences in spontaneous locomotion between aged torsinA(DeltaE) KI-Fbg1 knock out and control mice

Pig (Porcine) Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. This work reports the cloning and analysis of the porcine (Sus scrofa) homologue of TOR1A.

Torsin Family 1, Member A (Torsin A) (TOR1A) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.

Gene names and symbols associated with TOR1A

  • torsin family 1, member A (Tor1a) antibody
  • torsin family 1 member A (TOR1A) antibody
  • torsin family 1, member A (torsin A) (Tor1a) antibody
  • DQ2 antibody
  • DYT1 antibody
  • torsinA antibody

Protein level used designations for TOR1A

dystonia 1, torsion (autosomal dominant , dystonia 1, torsion (autosomal dominant; torsin A) , torsin A , torsin-1A , dystonia 1 protein , torsin family 1 member A

GENE ID SPECIES
266606 Rattus norvegicus
1861 Homo sapiens
30931 Mus musculus
100125953 Sus scrofa
533699 Bos taurus
Selected quality suppliers for anti-Torsin Family 1, Member A (Torsin A) (TOR1A) Antibodies
Did you look for something else?