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The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.. Additionally we are shipping Tousled-Like Kinase 2 Proteins (9) and and many more products for this protein.
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Human Polyclonal TLK2 Primary Antibody for ELISA, WB - ABIN544277
Silljé, Takahashi, Tanaka, Van Houwe, Nigg: Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. in The EMBO journal 1999
Show all 3 Pubmed References
haploinsufficiency of TLK2 is the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype.
Molecular basis of TLK2 activation and inhibition has been dissected.
TLK2 is amplified in aggressive luminal breast neoplasms
Tlk2 promotes Asf1A function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest.
Results show that TLK2 overexpression correlates with increased genome-wide copy number aberrations in breast cancer cells, impairs cell-cycle checkpoint signaling in response to DNA damage.
TLK2 plays a role in Kaposi's sarcoma-associated herpesvirus reactivation.
TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks.
ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.
TLK1 and TLK2 have largely redundant roles in genome maintenance.
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
tousled-like kinase 2
, Serine/threonine-protein kinase tousled-like 2
, serine/threonine kinase
, serine/threonine-protein kinase tousled-like 2
, pKU-alpha protein kinase
, protein kinase U-alpha