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The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. Additionally we are shipping TFE3 Kits (7) and TFE3 Proteins (6) and many more products for this protein.
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Human Polyclonal TFE3 Primary Antibody for ICC, IF - ABIN4361935
Hong, Oh, Valera, Baba, Schmidt, Linehan: Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization. in PLoS ONE 2011
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Human Monoclonal TFE3 Primary Antibody for IP, WB - ABIN967449
Beckmann, Su, Kadesch: TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif. in Genes & development 1990
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TFE3 may promote renal tumor growth by regulating cell cycle progression and activating the phosphatidylinositol 3kinase/AKT (show AKT1 Antibodies) serine/threonine kinase (show TLK2 Antibodies) 1/mTOR (show FRAP1 Antibodies) signaling pathway.
We report for the first time the presence of both TFE3 translocation and SDHB (show SDHB Antibodies) mutation in the same renal cell carcinoma (show MOK Antibodies) tumor.
TFEB (show TFEB Antibodies) and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines
Findings indicated that TFE3 was an important hypoxia-induced transcriptional factor in HNSCC.
Solid pseudopapillary neoplasms (SPNs) showed positive staining for SRY (show SRY Antibodies)-related high-mobility group box (show SSRP1 Antibodies) 11 (SOX-11 (show SOX11 Antibodies)), transcription factor E3 (TFE3) and beta-catenin (show CTNNB1 Antibodies) on cell blocks.
results reveal that PRCC (show PRCC Antibodies)-TFE3 dual-fusion FISH probe is an efficient and concise technique for diagnosing PRCC (show PRCC Antibodies)-TFE3 RCC (show XRCC1 Antibodies) in paraffin-embedded tissue
Case Report: Melanotic Xp11 renal cell carcinoma (show MOK Antibodies) with ARID1B (show ARID1B Antibodies)-TFE3 gene fusion.
Studies identified TFEB (show TFEB Antibodies) and TFE3 as master modulators of stress response notably in the lysosomal biogenesis and autophagy with capability to upregulate hundreds of genes involved in intracellular clearance, catabolism, metabolic processes, and cellular homeostasis.
Ovarian sclerosing stromal tumor strongly overexpress TFE3.
Describe the unusual morphology and expanded the morphologic spectrum of SFPQ/PSF (show SFPQ Antibodies)-TFE3 renal cell carcinomas.
These data indicate that TFE3 and TFEB (show TFEB Antibodies) play a cooperative, rather than redundant, role in the control of the adaptive response of whole-body metabolism to environmental cues such as diet and physical exercise.
Tfe3 and Tfeb (show TFEB Antibodies) are required for the induced expression of Ppargamma2 (show PPARG Antibodies) and subsequently for adipogenic genes.
Tfe3 overexpression in HSPCs impaired long-term hematopoietic reconstitution in vivo, recapitulating the Flcn (show FLCN Antibodies) KO phenotype, and supporting the notion that abnormal activation of Tfe3 contributes to the Flcn (show FLCN Antibodies) KO phenotype. Flcn (show FLCN Antibodies) KO mice develop an acute histiocytic hyperplasia in multiple organs, suggesting a novel function for Flcn (show FLCN Antibodies) in macrophage development
TFEB (show TFEB Antibodies) and TFE3 are novel components of the integrated stress response
Tfe3 is a critical transcription factor that regulates Pgc-1alpha gene expression in myotubes
A conditional expression in mice of the fusion gene ASPSCR1 (show ASPSCR1 Antibodies)-TFE3 from human alveolar soft part sarcoma (ASPS (show DARS Antibodies)) generated a model that recapitulates the human tumor histologically and by expression profile.
Data from transgenic mice suggest Tfe3 controls lipid metabolism in adipose tissue (white, WAT; brown, BAT (show BAAT Antibodies)); TFE3 appears to be regulated by diet; up-regulation of TFE3 may inhibit expression of lipolysis genes in WAT and thermogenesis genes in BAT (show BAAT Antibodies).
These findings indicated that TFE3 has a regulatory role in myoblast differentiation, and that transcriptional suppression of myogenin (show MYOG Antibodies) expression may be part of the mechanism of action.
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1)\; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.
class E basic helix-loop-helix protein 33
, transcription factor E family, member A
, transcription factor E3
, transcription factor for IgH enhancer
, transcription factor for immunoglobulin heavy-chain enhancer 3