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TSN encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations.
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Study describes the identification of translin (trsn), a highly conserved RNA/DNA binding protein (show CNBP ELISA Kits), as essential for starvation-induced sleep suppression. Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation.
These studies establish that Trax adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.
Drosophila translin exhibits a stable dimeric state that assembles into a suboctameric (tetramer/hexamer) form and fails (show AK3 ELISA Kits) to bind ssDNA and RNA targets
A translin null mutant was generated and a trax nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax.
Drosophila translin may have roles in neuronal development and behavior analogous to that of mouse translin.
Results suggest that the oligomeric status of translin critically influences the DNA binding properties of translin proteins.
an RNAi regulator that we term C3PO (component 3 promoter of RISC (show SCPEP1 ELISA Kits)), a complex of Translin and Trax was purified; C3PO is a Mg2 (show MCOLN1 ELISA Kits)+-dependent endoribonuclease that promotes RISC (show SCPEP1 ELISA Kits) activation by removing siRNA passenger strand cleavage products
Translin and Trax control telomere-associated transcript levels in human cells in a telomere-specific fashion.
results indicate that UPF1 can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay.
These findings indicate that miRNA depletion in dicer (show DICER1 ELISA Kits) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.
this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity.
The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO.
The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions.
Translin B3 motif, corresponding to TRAX B3 residues, contributes towards its DNA binding activity.
C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX subunits which activates RISC (show SCPEP1 ELISA Kits) by degrading the Ago2 (show EIF2C2 ELISA Kits)-nicked passenger strand of siRNA.
Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints.
study of reactivity of two -SH groups and stidu of proximity of Cys (show DNAJC5 ELISA Kits)-225 residues
Thus, the authors define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax.
These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF (show BDNF ELISA Kits) mRNA can be mediated by both translin-dependent and -independent mechanisms.
trax acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.
TB-RBP is involved in the posttranscriptional regulation of Gapds gene expression during spermiogenesis.
TB-RBP-null male mice were fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts. Null female mice were subfertile, had reduced litter sizes; analysis of brain RNA from null mice revealed an altered gene expression
TB-RBP-mouse ribonucleoprotein (show RBP31 ELISA Kits) complex transports a group of specific CREM (show CREM ELISA Kits)-regulated mRNAs in mammalian male postmeiotic germ cells.
TB-RBP post-transcriptionally stabilizes TRAX and both proteins are needed for normal cell proliferation
subcellular locations of TB-RBP and TRAX in male germ cells are modulated by the relative ratios of TRAX and TB-RBP
During a search for RNA-induced silencing complex (RISC (show SCPEP1 ELISA Kits)) proteins that directly interact with small interference RNA, the authors identify TB-RBP in NIH3T3 cell lysate and show that it possesses both single- and double-stranded RNase activities.
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.
, testis-brain RNA binding protein
, component 3 of promoter of RISC
, recombination hotspot associated factor
, recombination hotspot-binding protein
, testis brain-RNA binding protein
, testis/brain RNA-binding protein
, testis/brain-RNA-binding protein
, translin protein