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Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (By similarity). Additionally we are shipping Translocase of Inner Mitochondrial Membrane 50 Homolog (S. Cerevisiae) Kits (12) and Translocase of Inner Mitochondrial Membrane 50 Homolog (S. Cerevisiae) Proteins (5) and many more products for this protein.
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Human Polyclonal TIMM50 Primary Antibody for ELISA, WB - ABIN250292
Guo, Cheong, Zhang, De Rose, Deng, Farber, Fernandes-Alnemri, Alnemri: Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. in The Journal of biological chemistry 2004
A knockout mutant of the Arabidopsis TIM50 gene showed a reduction in hypocotyl length. TIM50 knockout caused enlargement and deformation of the mitochondrial structure and a reduction in intracellular ATP levels.
TIM50 deficiency increased heart and cardiomyocyte size with more severe cardiac fibrosis compared with wild-type littermates. In cardiomyocyte-specific TIM50 transgenic mice, the hypertrophic and fibrotic phenotypes were all alleviated.
Expression of TIM50 was downregulated in hypertrophic hearts.
Missense mutations in TIMM50 are likely manifesting by severe intellectual disability and epilepsy accompanied by 3-methylglutaconic aciduria and variable mitochondrial complex V deficiency.
TIM50 has a role in regulating cell proliferation and apoptosis through decreasing mitochondrial membrane potential in breast cancer cell
the interaction of divalent metal ions with the intermembrane space domain of Tim50 (Tim50(IMS)) and the interaction of presequence peptides with Tim50(IMS) in presence of Ca(2 (show CA2 Antibodies)+) ion was investigated.
The far-UV CD spectra of Tim50(IMS) in native and denatured states revealed that the protein has a significantly folded secondary structure consisted of alpha-helixes and beta-sheets.
Tim50 regulates 3betaHSD2 expression and activity, representing a new role for translocases in steroidogenesis.
TIM50, was upregulated in a non-small cell lung carcinoma cell line (H1299) that expressed the p53 (show TP53 Antibodies) mutants R175H and R273H compared to cells lacking p53 (show TP53 Antibodies).
Tim50 is important for both mitochondrial function and early neuronal development
Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with coilin (show COIL Antibodies), snRNPs, and SMN (show STMN1 Antibodies)
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (By similarity).
potential mitochondrial presequence translocase guide protein
, mitochondrial import inner membrane translocase subunit TIM50
, translocase of inner mitochondrial membrane 50 homolog
, Tim50-like protein
, homolog of yeast Tim50