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TM7SF4 encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. Additionally we are shipping Transmembrane 7 Superfamily Member 4 Antibodies (12) and and many more products for this protein.
Our results suggest that the rare genetic variant of TM7SF4 gene, found in our French-Canadian cohort of patients with Paget's disease of bone and which encodes the DC-STAMP protein, increase the number of nuclei per multinucleated cells and affect DC-STAMP expression during osteoclastogenesis in Paget's disease of bone.
TM7SF4 plays an essential role in regulating cell cycle progression in breast cancer.
The EP in TKA differed from EP in aseptically failed THA by lower CCL3 (show CCL3 ELISA Kits) and DC-STAMP mRNA and protein expression. EP of all studied inflammatory and osteoclastogenic molecules were similar in knee and hip OA.
Rs62620995 in the TM7SF4 gene was found to have a marginal association with Paget's disease of bone in the French-Canadian population.
DC-STAMP inhibition by RNA interference consequently suppressed fusion and bone resorption of human osteoclasts.
An interaction between OS9 (show OS9 ELISA Kits) and DC-STAMP was confirmed by yeast-2-hybrid analysis and cellular colocalization.ER-to-Golgi translocation of DC-STAMP following TLR stimulation in CHO (show COL11A1 ELISA Kits) cells was demonstrated, involving the DC-STAMP/OS9 (show OS9 ELISA Kits) interaction. The data indicate that OS9 (show OS9 ELISA Kits) is critically involved in ER-to-Golgi transport of DC-STAMP, and may be important in both myeloid differentiation and cell fusion.
DC-STAMP is an ITIM-bearing molecule. Based on the 4 distinct patterns of DCSTAMP on human PBMC, it has potential to serve as a susceptible biomarker of psoriasis (Ps) as well as severity marker of Psoriatic Arthritis (PsA).
Results show that T cells played a pivotal role in a new in vitro Langhans giant cells (LGCs) formation system, in which DC-STAMP was involved, and occurred via a molecular mechanism that involved CD40 (show CD40 ELISA Kits)-CD40L (show CD40LG ELISA Kits) interaction and IFN-gamma (show IFNG ELISA Kits) secretion.
genetic risk for Paget's disease of bone is associated with variants close to CSF1 (show CSF1 ELISA Kits), OPTN (show OPTN ELISA Kits), TM7SF4, and TNFRSF11A (show TNFRSF11A ELISA Kits) genes
DC-STAMP interacts with ER-resident transcription factor LUMAN (show CREB3 ELISA Kits) which becomes activated during DC maturation.
Immunoreceptor tyrosine-based inhibitory motif DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1 (show NFATC1 ELISA Kits)/Ca(2 (show CA2 ELISA Kits)+) axis.
These results suggest that Luman (show CREB3 ELISA Kits) regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and intracellular distribution during osteoclastogenesis.
miR (show MLXIP ELISA Kits)-7b inhibits osteoclastogenesis and cell-cell fusion by directly targeting DC-STAMP.
our data indicate that Pin1 (show PIN1 ELISA Kits) is a determinant of bone mass through the regulation of the osteoclast fusion protein DC-STAMP
Mechanical vibration of osteoclast precursor cells reduces DC-STAMP expression in osteoclast precursor cells.
DC-STAMP, Siglec-15, Tspan7 (show TSPAN7 ELISA Kits) and Mst1r (show MST1R ELISA Kits) expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
Results indicate that NFATc1 (show NFATC1 ELISA Kits) binding to the DC-STAMP promoter was inhibited by 60.9% with RvE1 treatment.
Strawberry notch (show NOTCH1 ELISA Kits) homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
These results suggest that short-term mechanical stress strongly inhibits osteoclastogenesis through the downregulation of DC-STAMP.
Fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP.
This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants.
transmembrane 7 superfamily member 4
, dendritic cell-specific transmembrane protein
, DC-specific transmembrane protein
, Dendritic cells (DC)-specific transmembrane protein
, IL-4-induced protein
, IL-Four (IL-4) induced
, IL-Four INDuced
, IL-four-induced protein
, dendrocyte-expressed seven transmembrane protein